SCLEROSIS

作品数:228被引量:453H指数:11
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相关领域:医药卫生更多>>
相关作者:韩月臣樊兆民刘梦琦陈志晔王燕玲更多>>
相关机构:山东省立医院学研究院山东大学中国人民解放军总医院更多>>
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相关基金:国家自然科学基金国家高技术研究发展计划北京市自然科学基金上海市教育委员会重点学科基金更多>>
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P2X7 receptors and multiple sclerosis: A potential biomarker and therapeutic target?
《Neural Regeneration Research》2026年第1期318-319,共2页Cristina Agliardi Franca Rosa Guerini Mario Clerici 
supported by Italian Ministry of Health Ricerca Corrente [RC 2023] and RF-2016-02361294;supported by#NEXTGENERATIONEU (NGEU);funded by the Ministry of University and Research (MUR);National Recovery and Resilience Plan (NRRP);project MNESYS (PE0000006)–A Multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022)(to FRG);partially supported by a grant from Fondazione Romeo ed Enrica Invernizzi (to FRG)。
Multiple sclerosis(MS) is a chronic, autoimmune and neuroinflammatory disease of the central nervous system(CNS) with a neurodegenerative component, characterized by demyelination and degeneration of nerve fibers. It ...
关键词:SCLEROSIS DEGENERATION THERAPEUTIC 
Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis
《Neural Regeneration Research》2025年第11期3229-3230,共2页Savina Apolloni Nadia D’Ambrosi 
funded by Fondazione AriSLA ETS(Fondazione di ricerca per la SLA ETS),ReNicALS project to SA;supported by#NEXTGENERATIONEU(NGEU)and funded by the Ministry of University and Research(MUR),National Recovery and Resilience Plan(NRRP),project MNESYS(PE0000006)-A Multiscale Integrated Approach to the Study of the Nervous System in Health and Disease(DN.1553 October 11,2022)。
Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and weakness.Although the clinical course is ...
关键词:STAT3 DISSECTION SCLEROSIS 
Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis
《Neural Regeneration Research》2025年第11期3217-3218,共2页Laura Huggon Emma L.Clayton 
funded by a senior research fellowship from Alzheimer’s Research UK (ARUK-SRF2022A-005);funded by a PhD studentship from Alzheimer’s Society (571);supported by the UK Dementia Research Institute through UK DRI Ltd.;principally funded by the UK Medical Research Council
Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping attributes.While these neurod...
关键词:DISEASES amyotrophic SCLEROSIS 
Translational challenges in amyotrophic lateral sclerosis therapy with macrophage migration inhibitory factor
《Neural Regeneration Research》2025年第9期2583-2584,共2页Leenor Alfahel Aleksandar Rajkovic Adrian Israelson 
supported by grants from the Israel Science Foundation(ISF#284/19);German Israeli Foundation(GIF#I-116-415.6-2016)(to AI)。
Macrophage migration inhibitory factor(MIF):MIF acts as a pleiotropic inflammatory mediator,playing regulatory roles in innate and adaptive immunity,neuroinflammation,neuroendocrine functions,and nervous system develo...
关键词:IMMUNITY SCLEROSIS 
Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology
《Neural Regeneration Research》2025年第9期2589-2590,共2页Mikio Shimizu Tatsusada Okuno 
supported in port by the JSPS KAKENHI(grant number 22K07539 to MS);funded by Mitsubishi Tanabe Pharma Corporation。
Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal cord.Patients with ALS develop skeletal muscle we...
关键词:PARALYSIS SCLEROSIS 
Carboplatin restores neuronal toxicity in FUS-linked amyotrophic lateral sclerosis
《Neural Regeneration Research》2025年第8期2319-2320,共2页Kiyoung Kim 
supported by the BK21 FOUR(Fostering Outstanding Universities for Research);the Basic Science Research Program through the National Research Foundation of Korea(NRF);the Regional Innovation Mega Project Program through the Korea Innovation Foundation funded by the Ministry of Education(MOE);the Ministry of Science and ICT(MSIT)(NRF-2022R1A2C1004204,RS-2023-00219563,2023-DD-UP-0007);the Soonchunhyang University Research Fund(to KK)。
Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal cord.This leads to muscle weakness,paralysis,and ul...
关键词:PARALYSIS SCLEROSIS RESPIRATORY 
Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter
《Neural Regeneration Research》2025年第5期1411-1413,共3页Marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz 
The lab of AK obtained support from the Interdisciplinary Center for Clinical Research(IZKF)Jena(MSP;Project ID:MSP09);DG and MJA B were supported by the Circular Vision project,which has received funding from the European Union's Horizon 2020 research and innovation program(Grant agreement No.899417);the Ministerio de Ciencia e Innovoción,Spain(Grant No.PID2020-119715GB-I00/AEI/10.13039/501100011033);the Instituto de Salud CarlosⅢ,Infrastructure of Precision Medicine associated with Science and Technology(IMPaCT)of the Strategic Action in Health(iDATAMP)(to MJAB)。
Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity an...
关键词:amyotrophic SCLEROSIS 
Alternations in morphometric similarity network in mesial temporal epilepsy correlate to neuroinflammatory pathway gene transcriptions
《Acta Epileptologica》2025年第1期94-104,共11页Lu Lu Chenyang Zhao Weihao Liao Peiyu Wang Yingying Zhang Dongmei An Xintong Wu Hesheng Zhang Ping Jiang Yaohui He Jinpeng Niu Wei Li Kangjia Chen Su Lui Yu Zhao Qiyong Gong Bo Wang Wei Liao Josemir W.Sander Lin Chen Dong Zhou 
supported by the National Natural Science Foundation of China(U21A20393);the 1.3.5 project for disciplines of excellence and the Brain Science project of West China Hospital(ZYGD23032);the postdoctoral research fund of West China Hospital(2024HXBH095);the National Key R&D Program(2021YFC2401204,2022YFC2503805);the NIHR University College London Hospitals Biomedical Research Centre;the UK Department of Health sponsors;support from the Marvin Weil Epilepsy Research Fund;the UK Epilepsy Society;the National Institute of Health Research;the Academy of Medical Sciences.
Background Mesial temporal lobe epilepsy(mTLE)is the most common form of focal epilepsy,often associated with hippocampal sclerosis.Increasing evidence suggests the pivotal role of neuroinflammation in mTLE onset and ...
关键词:Allen Human Brain Atlas Imaging transcriptome analysis Hippocampus sclerosis 
Multiple sclerosis is at a checkpoint: advancing the program
《Neural Regeneration Research》2025年第3期811-812,共2页Brandon C.Smith Jessica L.Williams 
Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b...
关键词:Hauser SCLEROSIS DAMAGE 
Neuronal STING activation mediates inflammation-induced neurodegeneration via ferroptosis pathways in multiple sclerosis
《Biophysics Reports》2024年第6期416-417,共2页Weiyan Wang Mengdi Guo Xiao Tu Meiling Jiang Cun-Jin Zhang 
Multiple sclerosis(MS)is a chronic autoimmune disease of the central nervous system(CNS)which leads to severe neurological disabilities,including motor and sensory deficits,cognitive impairment,and ultimately signific...
关键词:INFLAMMATION SCLEROSIS 
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