supported by the Keio University Medical Science Fund(to YO);the General Insurance Association of Japan(to YK);the Takeda Science Foundation(to YK);grants from the Japan Agency for Medical Research and Development(AMED)(Grant JP24bm1123037 and JP24ym0126118)(to HO)。
Spinal cord injury(SCI)can cause motor and sensory paralysis,and autonomic nervous system disorders including malfunction of urination and defecation,thereby significantly impairing the quality of life.Researchers con...
supported in port by the JSPS KAKENHI(grant number 22K07539 to MS);funded by Mitsubishi Tanabe Pharma Corporation。
Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal cord.Patients with ALS develop skeletal muscle we...
supported by the BK21 FOUR(Fostering Outstanding Universities for Research);the Basic Science Research Program through the National Research Foundation of Korea(NRF);the Regional Innovation Mega Project Program through the Korea Innovation Foundation funded by the Ministry of Education(MOE);the Ministry of Science and ICT(MSIT)(NRF-2022R1A2C1004204,RS-2023-00219563,2023-DD-UP-0007);the Soonchunhyang University Research Fund(to KK)。
Amyotrophic lateral sclerosis(ALS),also known as Lou Geh rig's disease,is a progressive neurodegenerative disorder that affects motor neurons in the brain and spinal cord.This leads to muscle weakness,paralysis,and ul...
approved by the Ethics Committee of the First Affiliated Hospital of University of Science and Technology of China(Anhui Provincial Hospital)(2024-RE-325)。
Background Hemorrhagic stroke has a high incidence,often leaving patients with significant complications such as limb mobility disorders after treatment.Traditional treatment methods for stroke patients mainly include...
BACKGROUND Thyrotoxic periodic paralysis(TPP)is an endocrine emergency caused by thyrotoxicosis,manifesting mainly as periodic myasthenia and hypokalemia,and posing a serious threat to the patient's health.Fatigue,str...
supported by the Natural Science Foundation of Fujian Province,No.2020J02027;the National Natural Science Foundation of China,No.31970461;the Foundation of NHC Key Laboratory of Technical Evaluation of Fertility Regulation for Non-human Primate,Fujian Maternity and Child Health Hospital,No.2022-NHP-05(all to WC).
Certain amino acids changes in the human Na^(+)/K^(+)-ATPase pump,ATPase Na^(+)/K^(+)transporting subunit alpha 1(ATP1A1),cause Charcot-Marie-Tooth disease type 2(CMT2)disease and refractory seizures.To develop in viv...
Axon disconnection in the central nervous system(CNS) usually causes signal transduction failure and severe functional deficits in patients with neurological disorders. Currently, there is no cure for patients with CN...
Supported by the National Key Research and Development Program of China:Evidence Based Study on the Treatment of Post Stroke Motor Aphasia with the Rehabilitation Plan of“Xing Nao Kai Qiao”(No.2018YFC1706001)。
Stroke is the main cause of disability in the middle and old age.Hemiplegia,especially lower limb paralysis,often leads to the loss of self-care ability and a series of secondary injuries.The main method to improve he...
support from the Robert Campeau Family Foundation/Dr.C.H.Tator Chair in Brain and Spinal Cord Research at UHN.
Injury to the spinal cord can disrupt the neural circuits necessary for locomotion.In a recent paper published in Nature,Lorach et al.demonstrate the feasibility of implementing a‘digital bridge’between the brain an...
supported by Guangzhou Municipal Science and Technology Bureau(No.2024A04J5124)。
INTRODUCTION The medulla oblongata is located at the lowest end of the brainstem.Damage to the ambiguous nucleus at the level of the upper medulla oblongata can lead to swallowing disorders,paralysis of the ipsilatera...