Disruption of neuronal actin barrier promotes the entry of disease-implicated proteins to exacerbate amyotrophic lateral sclerosis pathology  

作　　者：Mikio Shimizu Tatsusada Okuno 

机构地区：[1]Department of Neurology,Osaka University Graduate School of Medicine,Suita,Japan [2]Department of Neurology,Osaka General Medical Center,Osaka,Japan

出　　处：《Neural Regeneration Research》2025年第9期2589-2590,共2页中国神经再生研究（英文版）

基　　金：supported in port by the JSPS KAKENHI(grant number 22K07539 to MS);funded by Mitsubishi Tanabe Pharma Corporation。

摘　　要：Amyotrophic lateral sclerosis(ALS)is a devastating neurological disease characterized by the accumulation of aberrant proteins in motor neurons of the brain and spinal cord.Patients with ALS develop skeletal muscle weakness,resulting in death from respiratory paralysis,which usually occurs 2-4 years after clinical onset(Goutman et al.,2022).

关 键 词：PARALYSIS SCLEROSIS 

分 类 号：R744.8[医药卫生—神经病学与精神病学]