THERAPEUTIC

作品数：1236被引量：4217H指数：27
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相关领域：医药卫生更多>>
相关作者：朱祥英闫晓燕李滋平金征宇王志伟更多>>
相关机构：复旦大学上海中医药大学北京大学中山大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划北京市自然科学基金更多>>
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P2X7 receptors and multiple sclerosis: A potential biomarker and therapeutic target?
《Neural Regeneration Research》2026年第1期318-319,共2页Cristina Agliardi Franca Rosa Guerini Mario Clerici 
supported by Italian Ministry of Health Ricerca Corrente [RC 2023] and RF-2016-02361294;supported by#NEXTGENERATIONEU (NGEU);funded by the Ministry of University and Research (MUR);National Recovery and Resilience Plan (NRRP);project MNESYS (PE0000006)–A Multiscale integrated approach to the study of the nervous system in health and disease (DN. 1553 11.10.2022)(to FRG);partially supported by a grant from Fondazione Romeo ed Enrica Invernizzi (to FRG)。
Multiple sclerosis(MS) is a chronic, autoimmune and neuroinflammatory disease of the central nervous system(CNS) with a neurodegenerative component, characterized by demyelination and degeneration of nerve fibers. It ...
关键词：SCLEROSIS DEGENERATION THERAPEUTIC 
Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease
《Neural Regeneration Research》2025年第10期2919-2920,共2页Yingli Gu Kijung Sung Chengbiao Wu 
Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”...
关键词：HUNTINGTON HOMEOSTASIS THERAPEUTIC 
In vivo direct neuronal conversion as a therapeutic strategy for ischemic stroke被引量：1
《Neural Regeneration Research》2025年第8期2309-2310,共2页Takashi Irie Taito Matsuda 
supported by JSPS KAKENHI Grant Number JP24K18622(to TI);JSPS KAKENHI Grant Number JP23K18451(to TM)。
Stroke causes neuronal loss,which ultimately results in persistent neurological dysfunction.Globally,stroke was the third-leading cause of death and disability combined in all ages in 2019,after neonatal disorders and...
关键词：NEONATAL DEATH THERAPEUTIC 
Insights into spinal muscular atrophy from molecular biomarkers被引量：1
《Neural Regeneration Research》2025年第7期1849-1863,共15页Xiaodong Xing Xinzhu Liu Xiandeng Li Mi Li Xian Wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang 
supported by the Collaborative Innovation Center for Clinical and Translational Science by Chinese Ministry of Education&Shanghai,No.CCTS-2022205;the“Double World-Class Project”of Shanghai Jiaotong University School of Medicine(both to JZ)。
Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle weakness.It is one of the most common genetic causes of mortality among infants aged less than 2 years.Biomar...
关键词：biomarkers disease progression gene-targeting therapy NEUROFILAMENTS Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes 
Complement-dependent neuroinflammation in spinal cord injury:from pathology to therapeutic implications
《Neural Regeneration Research》2025年第5期1324-1335,共12页Hassan Saad Bachar El Baba Ali Tfaily Firas Kobeissy Juanmarco Gutierrez Gonzalez Daniel Refai Gerald R.Rodts Christian Mustroph David Gimbel Jonathan Grossberg Daniel L.Barrow Matthew F.Gary Ali M.Alawieh 
supported by the Department of Veterans Affairs(VA Merit Award BX004256)(to AMA);Emory Department of Neurosurgery Catalyst Grant;Emory Medical Care Foundation Grant(to AMA and JG)。
Spinal cord injury remains a major cause of disability in young adults,and beyond acute decompression and rehabilitation,there are no pharmacological treatments to limit the progression of injury and optimize recovery...
关键词：COMPLEMENT NEUROINFLAMMATION NEUROPLASTICITY regeneration spinal cord injury targeted therapy 
Personalized therapeutic approaches for improved glycemic outcomes in type 2 diabetes
《World Journal of Diabetes》2025年第5期458-463,共6页Eguono Deborah Akpoveta Uchenna E Okpete Haewon Byeon 
Supported by Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education,No.NRF-RS-2023-00237287。
Managing type 2 diabetes mellitus remains a significant challenge,particularly for individuals with persistently poor glycemic control.Although inadequate glycemic regulation is a well-established public health concer...
关键词：Glycemic trajectories Personalized treatment Diabetes control Therapeutic inertia Glycated hemoglobin improvement Metabolic challenges 
Comprehensive Integration of the Operational Principles of Diabetic Foot Therapeutic Devices with Technological Innovations
《Medicinal Plant》2025年第2期75-80,共6页Jinting ZHOU Yanliang CHEN Dongnian WU Lingjun HUANG Yao YAO Yu DIAO 
Supported by Undergraduate Innovation and Entrepreneurship Training Program(S202410599085).
This paper offers a comprehensive overview of the operational principles of current therapeutic devices for diabetic foot management and further analyzes technological innovations and developmental trends,aiming to pr...
关键词：Diabetic foot therapeutic device Operational principle Technological innovation Technological convergence 
Exploring Therapeutic Design of Outdoor Landscape for Medical Buildings Enabled by Wisdom:A Case Study of the Fifth People’s Hospital of Chongqing
《Journal of World Architecture》2025年第2期61-68,共8页Linye Gao Haihe Zhao 
Research Fund Projects of Chongqing Institute of Engineering:Research on the Intelligent Design of Indoor and Outdoor Spaces for Chongqing’s“Integrated Medical and Elderly Care”Health and Wellness Buildings in the Context of Digitization(Project No.:2023xsky01);Research on Spatial Syntax Parameters and Combination Patterns of Urban and Rural Community Elderly Care Centers from a Multi-Dimensional Perspective(Project No.:2024XZKY003);2024 Curriculum Ideological and Political Demonstration Course Construction Project of Chongqing Institute of Engineering,“Residential Landscape Design”(Project No.:KC20240006)。
The outdoor landscape design of medical buildings affects the healthcare experience of patients and the work environment of medical staff.Therapeutic landscapes contribute to the recovery of patients and provide a com...
关键词：Medical buildings Smart empowerment Outdoor landscapes THERAPEUTIC 
Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease
《Neural Regeneration Research》2025年第4期1094-1095,共2页Natalia Kulesskaya Kira M.Holmström Henri J.Huttunen 
supported by Herantis Pharma Plc and the European Innovation Council(grant acronym ReTreatPD).
Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A major unmet need in the field of central nervous system diseases is disease-modifying treatments.While for decades there have been various...
关键词：DISEASES treatment THERAPEUTIC 
The implications of single-cell RNA-seq analysis in prostate cancer:unraveling tumor heterogeneity,therapeutic implications and pathways towards personalized therapy
《Military Medical Research》2025年第2期220-241,共22页De-Chao Feng Wei-Zhen Zhu Jie Wang Deng-Xiong Li Xu Shi Qiao Xiong Jia You Ping Han Shi Qiu Qiang Wei Lu Yang 
Chinese Scholarship Council(202206240086);National Natural Science Foundation of China(81974099,82170785,81974098,82170784);National Key Research and Development Program of China(2021YFC2009303);programs from Science and Technology Department of Sichuan Province(2021YFH0172);Young Investigator Award of Sichuan University 2017(2017SCU04A17);Technology Innovation Research and Development Project of Chengdu Science and Technology Bureau(2019-YF05-00296-SN);Sichuan University-Panzhihua science and technology cooperation special fund(2020CDPZH-4).
In recent years,advancements in single-cell and spatial transcriptomics,which are highly regarded developments in the current era,particularly the emerging integration of single-cell and spatiotemporal transcriptomics...
关键词：Prostate cancer Single-cell RNA sequencing(scRNA-seq) Tumor microenvironment Tumor heterogeneity Treatment resistance Precision medicine 
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