supported by NIH/NICHD RO1HD109157;supported by his American Heart AssociationAward Career Development Award (932980);National Science Foundation CAREER award (NSF2401215)
Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Hunting...
Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”...
supported by the Deutsche Forschungsgemeinschaft(DFG;grant#521487152)(to AF)。
TDP-43 proteinopathies and cryptic exons:Transactive response DNA binding protein of 43 kDa(TDP-43)is a ubiquitously expressed RNA/DNA binding protein crucial for coding and non-coding RNA metabolism including transcr...
In 1872, George Huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. Huntington's disease(HD) is a genetic, neuro...
Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and cortex.Patients can present with a variety of symptoms that can broadly be classified into motor symptoms...
Tandem repeats(TRs)are DNA sequences where specific nucleotide patterns are repeated consecutively along the DNA strand.TRs(~8.1%of the genome)constitute a substantial source of genetic diversity within the human geno...
supported by the National Natural Science Foundation of China(No.81970431);the Hunan Provincial Natural Science Foundation of China(No.2023JJ50136)。
Neurodegenerative diseases(NDDs),mainly including Huntington’s disease(HD),amyotrophic lateral sclerosis(ALS),and Alzheimer’s disease(AD),are sporadic and rare genetic disorders of the central nervous system.A key f...
Neurodegenerative diseases(NDDs)are a class of disorders characterized by the gradual loss or malfunction of specific cell populations in the nervous system,which can be triggered by genetic or environmental factors.A...
People with neurodegenerative disorders often experience problems across a variety of functional domains,including cognition,movement,and psychosocial functioning.The classification of these disorders is based on the ...
supported by the Basic Science Center Program of the National Natural Science Foundation of China (31988101);the National Key R&D Program of China (2021YFA0805800);the National Natural Science Foundation of China (3197085)。
Ribosome-associated protein quality control (RQC) is a surveillance system that detects translation stalling events and degrades incomplete or defective polypeptides. This process maintains protein homeostasis and pro...