HUNTINGTON

作品数:134被引量:122H指数:5
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相关领域:医药卫生生物学更多>>
相关作者:张如意李林张兰冯美江吴文权更多>>
相关机构:首都医科大学宣武医院华中科技大学上海医科大学北京协和医院更多>>
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相关基金:国家自然科学基金国家重点基础研究发展计划北京市教育委员会科技发展计划江苏省社会发展科技计划更多>>
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Sex differences in aging and injured brain
《Neural Regeneration Research》2025年第10期2901-2902,共2页Jordan N.Williamson Yuan Yang 
supported by NIH/NICHD RO1HD109157;supported by his American Heart AssociationAward Career Development Award (932980);National Science Foundation CAREER award (NSF2401215)
Background:The prevalence,age of onset,and symptomatology of traumatic brain injury,stroke,and neurodegenerative diseases(such as Alzheimer’s disease(AD),Parkinson’s disease,amyotrophic lateral sclerosis,and Hunting...
关键词:HUNTINGTON PREVALENCE TRAUMATIC 
Brain-derived neurotrophic factor plays with TRiC:focus on synaptic dysfunction in Huntington’s disease
《Neural Regeneration Research》2025年第10期2919-2920,共2页Yingli Gu Kijung Sung Chengbiao Wu 
Brain-derived neurotrophic factor(BDNF)exerts pleiotropic effects on brain processes including psychiatric disorders,aging,neurodegeneration,and metabolic homeostasis.A simple PubMed search using the key word“BDNF,”...
关键词:HUNTINGTON HOMEOSTASIS THERAPEUTIC 
Cryptic exon inclusion in TDP-43 proteinopathies:opportunities and challenges
《Neural Regeneration Research》2025年第7期2003-2004,共2页Lorena Decker Sonja Menge Axel Freischmidt 
supported by the Deutsche Forschungsgemeinschaft(DFG;grant#521487152)(to AF)。
TDP-43 proteinopathies and cryptic exons:Transactive response DNA binding protein of 43 kDa(TDP-43)is a ubiquitously expressed RNA/DNA binding protein crucial for coding and non-coding RNA metabolism including transcr...
关键词:HUNTINGTON METABOLISM TDP 
Neuroinflammation as a therapeutic target in Huntington's disease
《Neural Regeneration Research》2025年第3期817-818,共2页Andrea Kwakowsky Thulani H.Palpagama 
In 1872, George Huntington presented his essay “On Chorea” to the Meigs and Mason Academy of Medicine and, in doing so, detailed a disease that would later bear his name. Huntington's disease(HD) is a genetic, neuro...
关键词:HUNTINGTON INFLAMMATION MEDICINE 
Glial response in the midcingulate cortex in Huntington’s disease
《Neural Regeneration Research》2025年第1期207-208,共2页Thulani H.Palpagama Andrea Kwakowsky 
Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and cortex.Patients can present with a variety of symptoms that can broadly be classified into motor symptoms...
关键词:HUNTINGTON DEGENERATION CORTEX 
Advancements and future perspectives of human tandem repeats
《Science Bulletin》2024年第23期3633-3636,共4页Wenbin Ye Jason Sheng Li Wei Li Ya Cui 
Tandem repeats(TRs)are DNA sequences where specific nucleotide patterns are repeated consecutively along the DNA strand.TRs(~8.1%of the genome)constitute a substantial source of genetic diversity within the human geno...
关键词:HUNTINGTON LIMITATIONS typically 
Autophagy receptor-inspired chimeras:a novel approach to facilitate the removal of protein aggregates and organelle by autophagy degradation
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第12期1115-1119,共5页Liwen WANG Huimei LIU Lanfang LI 
supported by the National Natural Science Foundation of China(No.81970431);the Hunan Provincial Natural Science Foundation of China(No.2023JJ50136)。
Neurodegenerative diseases(NDDs),mainly including Huntington’s disease(HD),amyotrophic lateral sclerosis(ALS),and Alzheimer’s disease(AD),are sporadic and rare genetic disorders of the central nervous system.A key f...
关键词:HUNTINGTON DISEASES ALZHEIMER 
Advancements in personalized stem cell models for aging-related neurodegenerative disorders
《Neural Regeneration Research》2024年第11期2333-2334,共2页Mingxi Weng Ralf Jauch 
Neurodegenerative diseases(NDDs)are a class of disorders characterized by the gradual loss or malfunction of specific cell populations in the nervous system,which can be triggered by genetic or environmental factors.A...
关键词:DEGENERATIVE HUNTINGTON SENSATION 
Cognition and movement in neurodegenerative disorders:a dynamic duo
《Neural Regeneration Research》2024年第10期2101-2102,共2页Marit F.L.Ruitenberg 
People with neurodegenerative disorders often experience problems across a variety of functional domains,including cognition,movement,and psychosocial functioning.The classification of these disorders is based on the ...
关键词:DISORDERS HUNTINGTON DEGENERATIVE 
神经退行性疾病研究及治疗新方向:核糖体相关蛋白质量控制
《Science Bulletin》2024年第9期1165-1169,共5页高亚杰 朱元祥 孙钦秒 陈大华 
supported by the Basic Science Center Program of the National Natural Science Foundation of China (31988101);the National Key R&D Program of China (2021YFA0805800);the National Natural Science Foundation of China (3197085)。
Ribosome-associated protein quality control (RQC) is a surveillance system that detects translation stalling events and degrades incomplete or defective polypeptides. This process maintains protein homeostasis and pro...
关键词:神经退行性疾病 HUNTINGTON ALZHEIMER 
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