神经退行性疾病研究及治疗新方向:核糖体相关蛋白质量控制  

Ribosome-associated protein quality control:Implications for neurodegenerative diseases and therapeutic potential

作　　者：高亚杰 朱元祥 孙钦秒 陈大华 Yajie Gao;Yuanxiang Zhu;Qinmiao Sun;Dahua Chen(Institute of Biomedical Research,Yunnan University,Kunming 650500,China;State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China;Institute of Stem Cells and Regeneration,Chinese Academy of Sciences,Beijing 100101,China;Southwest United Graduate School,Kunming 650500,China)

机构地区：[1]Institute of Biomedical Research,Yunnan University,Kunming 650500,China [2]State Key Laboratory of Membrane Biology,Institute of Zoology,Chinese Academy of Sciences,Beijing 100101,China [3]Institute of Stem Cells and Regeneration,Chinese Academy of Sciences,Beijing 100101,China [4]Southwest United Graduate School,Kunming 650500,China

出　　处：《Science Bulletin》2024年第9期1165-1169,共5页科学通报（英文版）

基　　金：supported by the Basic Science Center Program of the National Natural Science Foundation of China (31988101);the National Key R&D Program of China (2021YFA0805800);the National Natural Science Foundation of China (3197085)。

摘　　要：Ribosome-associated protein quality control (RQC) is a surveillance system that detects translation stalling events and degrades incomplete or defective polypeptides. This process maintains protein homeostasis and protects cells from proteotoxic stress. Evidence of compromised RQC functionality has been observed in the aging process and in several age-related neurodegenerative afflictions, including amyotrophic lateral sclerosis, Parkinson’s disease (PD), Huntington’s disease (HD), and Alzheimer’s disease (AD)。

关 键 词：神经退行性疾病 HUNTINGTON ALZHEIMER 

分 类 号：R741[医药卫生—神经病学与精神病学]