Glial response in the midcingulate cortex in Huntington’s disease  

作　　者：Thulani H.Palpagama Andrea Kwakowsky 

机构地区：[1]Center for Brain Research and Department of Anatomy and Medical Imaging,Faculty of Medical and Health Sciences,University of Auckland,Auckland,New Zealand [2]Pharmacology and Therapeutics,School of Medicine,Galway Neuroscience Center,University of Galway,Galway,Ireland

出　　处：《Neural Regeneration Research》2025年第1期207-208,共2页中国神经再生研究（英文版）

摘　　要：Huntington’s disease(HD)is a genetic disease characterized by the progressive degeneration of the striatum and cortex.Patients can present with a variety of symptoms that can broadly be classified into motor symptoms,inclusive of choreatic movements and rigidity,mood and psychiatric symptoms,such as depression and apathy,and cognitive symptoms,such as cognitive decline.The causal mutation underlying HD results from an expansion of a CAG repeat sequence on the IT15 gene,resulting in the formation and accumulation of a mutant huntingtin protein.

关 键 词：HUNTINGTON DEGENERATION CORTEX 

分 类 号：R742.2[医药卫生—神经病学与精神病学]