Small extrachromosomal circular DNA in amyotrophic lateral sclerosis matter  

作　　者：Marcos J.Arauzo-Bravo Daniela Gerovska Matthias Schwab Alexandra Kretz 

机构地区：[1]Computational Biology and Systems Biomedicine,Biodonostia Health Research Institute,San Sebastian,Spain [2]Basque Foundation for Science,IKERBASQUE,Bilbao,Spain,Max Planck Institute for Molecular Biomedicine,Computational Biology and Bioinformatics Group,Münster,North Rhine-Westphalia,Germany [3]Department of Cell Biology and Histology,Faculty of Medicine and Nursing,University of Basque Country(UPV/EHU),Leioa,Spain [4]Department of Neurology,Jena University Hospital,Jena,Thuringia,Germany

出　　处：《Neural Regeneration Research》2025年第5期1411-1413,共3页中国神经再生研究（英文版）

基　　金：The lab of AK obtained support from the Interdisciplinary Center for Clinical Research(IZKF)Jena(MSP;Project ID:MSP09);DG and MJA B were supported by the Circular Vision project,which has received funding from the European Union's Horizon 2020 research and innovation program(Grant agreement No.899417);the Ministerio de Ciencia e Innovoción,Spain(Grant No.PID2020-119715GB-I00/AEI/10.13039/501100011033);the Instituto de Salud CarlosⅢ,Infrastructure of Precision Medicine associated with Science and Technology(IMPaCT)of the Strategic Action in Health(iDATAMP)(to MJAB)。

摘　　要：Comprehensive studies identify motor neuron spectrum disorders including amyotrophic lateral sclerosis(ALS)as globally rising fatal disorders with the highest prevalence in aging populations,influenced by ethnicity and ancestry(GBD 2016 Motor Neuron Disease Colla borators,2018).While~10% of diagnoses involve a family history(fALS),most cases are considered sporadic(sALS).However,population-based studies suggest that even cases without a common index mutation impart heritability(Ryan et al.,2019),indicating a crucial role of rare and as yet unknown genetic denominators.

关 键 词：amyotrophic SCLEROSIS 

分 类 号：R744.8[医药卫生—神经病学与精神病学]