Alternations in morphometric similarity network in mesial temporal epilepsy correlate to neuroinflammatory pathway gene transcriptions  

作　　者：Lu Lu Chenyang Zhao Weihao Liao Peiyu Wang Yingying Zhang Dongmei An Xintong Wu Hesheng Zhang Ping Jiang Yaohui He Jinpeng Niu Wei Li Kangjia Chen Su Lui Yu Zhao Qiyong Gong Bo Wang Wei Liao Josemir W.Sander Lin Chen Dong Zhou 

机构地区：[1]Department of Neurology,&Institute of Brain Science and Brain‑Inspired Technology,West China Hospital,Sichuan University,Chengdu 610041,Sichuan,China [2]Department of Radiology,West China Hospital,Sichuan University,Sichuan Province,Chengdu 610041,China [3]The Clinical Hospital of Chengdu Brain Science Institute,School of Life Science and Technology,University of Electronic Science and Technology of China,Chengdu 610054,China [4]State Key Laboratory of Brain and Cognitive Science,Institute of Biophysics,University of the Chinese Academy of Sciences,Beijing 100101,China [5]Department of Clinical and Experimental Epilepsy,UCL Queen Square Institute of Neurology,London WC1N 3BG,UK.

出　　处：《Acta Epileptologica》2025年第1期94-104,共11页癫痫学报(英文)

基　　金：supported by the National Natural Science Foundation of China(U21A20393);the 1.3.5 project for disciplines of excellence and the Brain Science project of West China Hospital(ZYGD23032);the postdoctoral research fund of West China Hospital(2024HXBH095);the National Key R&D Program(2021YFC2401204,2022YFC2503805);the NIHR University College London Hospitals Biomedical Research Centre;the UK Department of Health sponsors;support from the Marvin Weil Epilepsy Research Fund;the UK Epilepsy Society;the National Institute of Health Research;the Academy of Medical Sciences.

摘　　要：Background Mesial temporal lobe epilepsy(mTLE)is the most common form of focal epilepsy,often associated with hippocampal sclerosis.Increasing evidence suggests the pivotal role of neuroinflammation in mTLE onset and progression.Methods We used morphometric similarity network(MSN)analysis and the Allen Human Brain Atlas(AHBA)database to investigate structural changes between mTLE and healthy controls,as well as correlation with inflammation-related gene expression.Results We identified widespread alterations across the frontal and parietal lobes and cingulate cortex linked to neuroinflammatory genes such as PRR5,SMAD3,and IRF3.This correlation was even more pronounced in mTLE patients with hippocampal sclerosis compared to those without.Enrichment analysis highlighted pathways related to neurodevelopment and neurodegeneration,supporting a bidirectional link between mTLE and neurodegenerative diseases.Conclusions These findings suggest that brain-wide macroscopic morphometric alternations in mTLE are correlated to the neuroinflammation process.It provides circumstantial evidence from a new perspective to support the bidirectional link between mTLE and neurodegenerative diseases.

关 键 词：Allen Human Brain Atlas Imaging transcriptome analysis Hippocampus sclerosis 

分 类 号：R74[医药卫生—神经病学与精神病学]