Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis  

作　　者：Laura Huggon Emma L.Clayton 

机构地区：[1]UK Dementia Research Institute at King’s College London,London,UK [2]Department of Basic and Clinical Neuroscience,Institute of Psychiatry Psychology&Neuroscience,King’s College London,London,UK

出　　处：《Neural Regeneration Research》2025年第11期3217-3218,共2页中国神经再生研究（英文版）

基　　金：funded by a senior research fellowship from Alzheimer’s Research UK (ARUK-SRF2022A-005);funded by a PhD studentship from Alzheimer’s Society (571);supported by the UK Dementia Research Institute through UK DRI Ltd.;principally funded by the UK Medical Research Council

摘　　要：Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(ALS)are neurodegenerative diseases with significant overlapping attributes.While these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and ALS affecting upper and lower motor neurons),these two diseases are complexly intertwined.FTD and ALS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关 键 词：DISEASES amyotrophic SCLEROSIS 

分 类 号：R749.1[医药卫生—神经病学与精神病学] R744.8[医药卫生—临床医学]