Security breach:peripheral nerves provide unrestricted access for toxin delivery into the central nervous system  

作　　者：Igor Lupinski Allison SLiang Randall D.McKinnon 

机构地区：[1]Department of Neurosurgery and Member,The Cancer Institute of New Jersey,Rutgers-Robert Wood Johnson Medical School,Piscataway,NJ,USA

出　　处：《Neural Regeneration Research》2023年第1期64-67,共4页中国神经再生研究（英文版）

基　　金：supported by grants from the New Jersey Commission on Spinal Cord Research (05-3047;11-015)

摘　　要：We explore the hypothesis that a potential explanation for the initiation of motor neuron disease is an unappreciated vulnerability in central nervous system defense,the direct delivery of neurotoxins into motor neurons via peripheral nerve retrograde transport.This further suggests a mechanism for focal initiation of neuro-degenerative diseases in general,with subsequent spread by network degeneration as suggested by the Frost-Diamond hypothesis.We propose this vulnerability may be a byproduct of vertebrate evolution in a benign aquatic environment,where external surfaces were not exposed to concentrated neurotoxins.

关 键 词：amyotrophic lateral sclerosis BIOACCUMULATION NEURODEGENERATION NEUROPATHOLOGY NEUROTOXINS peripheral nerves retrograde transport retrotoxicity suicide transport 

分 类 号：R741[医药卫生—神经病学与精神病学]