Misfolded amyloid-beta conformational variants(strains)as drivers of Alzheimer's disease neuropathology  

作　　者：Salvatore Saieva Rodrigo Morales 

机构地区：[1]Department of Neurology,The University of Texas Health Science Center at Houston,Houston,TX,USA [2]Centro Integrativo de Biologia y Quimica Aplicada(CIBQA),Universidad Bernardo O’Higgins,Santiago,Chile

出　　处：《Neural Regeneration Research》2025年第11期3219-3220,共2页中国神经再生研究（英文版）

基　　金：supported by a grant from NIH(R01AI132695)to RM。

摘　　要：Pathological and clinical variability in Alzheimer's disease(AD):AD is clinically cha racterized by progressive memory loss and cognitive impairment.From a pathological point of view,the main features of AD are the deposition of amyloid plaques(composed of amyloid-beta,Aβ)and neurofibrillary tangles containing hyperphosphorylated Tau in the brain,accompanied by neu ronal and synaptic loss,neuroinflammation and brain atrophy(Jellinger,2022).Regardless of these common traits,growing evidence shows increased heterogen eity in the brain of AD patients considering both clinical manifestations and pathological features.

关 键 词：AMYLOID ALZHEIMER clinical 

分 类 号：R749.16[医药卫生—神经病学与精神病学]