METHYLATION

作品数：689被引量：2381H指数：20
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相关领域：医药卫生生物学更多>>
相关作者：周静东钱军林江孙俊宁张盈盈更多>>
相关机构：北京大学江苏大学附属人民医院信息科学与技术学院哈尔滨工业大学更多>>
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Epigenetic regulation of the inflammatory response in stroke
《Neural Regeneration Research》2025年第11期3045-3062,共18页Jingyi Liang Fei Yang Zixiao Li Qian Li 
supported by the National Natural Science Foundation of China,Nos.32070735(to QL),82371321(to QL),82171270(to ZL);Public Service Platform for Artificial Intelligence Screening and Auxiliary Diagnosis for the Medical and Health Industry,Ministry of Industry and Information Technology of the People's Republic of China,No.2020-0103-3-1(to ZL);the Natural Science Foundation of Beijing,No.Z200016(to ZL);Beijing Talents Project,No.2018000021223ZK03(to ZL);Beijing Municipal Committee of Science and Technology,No.Z201100005620010(to ZL)。
Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either type.Immunologic mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytoki...
关键词：DNA methylation histone modification intracerebral hemorrhage ischemic stroke NEUROINFLAMMATION NEUROPROTECTION non-coding RNA RNA methylation subarachnoid hemorrhage treatment 
Multi-omics analysis reveals the epitranscriptomic and proteomic regulation network of tomato in low-temperature stress response
《Horticultural Plant Journal》2025年第2期758-773,共16页Na Wang Yanting Li Tianli Guo Libo Jiang 
financially supported by the National Natural Science Foundation of China(Grant Nos.32202518 and 32070601);Shandong University of Technology PhD Start-up Fund(418097)。
Tomato(Solanum lycopersicum)is an extensively cultivated vegetable,and its growth and fruit quality can be significantly impaired by low temperatures.The widespread presence of N^(6)-methyladenosine(m^(6)A)modificatio...
关键词：Epitranscriptome m^(6)A methylation PROTEOME Alternative polyadenylation Low temperature TOMATO 
DNMT1 promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein
《World Journal of Gastrointestinal Oncology》2025年第3期188-201,共14页Hui Xie Hui Wang Ru-Hong Li Yue-Wen Zhang Xi-Rui Fan Xiao-Xue He Ao-Ran Guan 
the Research Program of the Science and Technology Department of Yunnan Province,No.202101AY070001-204.
BACKGROUND Gastric cancer(GC)is a malignant tumor originating from gastric mucosal epithelial cells that has high morbidity and mortality.microRNAs(miR)are important diagnostic markers and therapeutic targets in this ...
关键词：Gastric cancer microRNA-125a-5p DNA methyltransferase 1 SERPINE1 METHYLATION 
SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM
《Science China(Life Sciences)》2025年第3期793-808,共16页Hongguo Duan Shuang Wang Wen-Jie Shu Yongjia Tong Hai-Zhen Long Guohong Li Hai-Ning Du Meng-Jie Zhao 
supported by the National Key Research and Development program of China(2023YF0913403);the National Natural Science Foundation of China(32200584,31971231);the Fundamental Research Funds for the Central Universities(2042022dx0003,2042022kf1048);the China Postdoctoral Science Foundation(2021M702526).
The minichromosome maintenance complex(MCM)DNA helicase is an important replicative factor during DNA replication.The proper chromatin loading of MCM is a key step to ensure replication initiation during S phase.Becau...
关键词：histidine methylation SETD3 DNA replication MCM replication origin firing 
Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy被引量：1
《Neural Regeneration Research》2025年第3期887-899,共13页Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen 
supported by the National Natural Science Foundation of China,Nos.82271283(to XC),91854115(to JW),31970044(to JW);the Natural Science Foundation of Beijing,No.7202001(to XC);the Scientific Research Project of Beijing Educational Committee,No.KM202010005022(to XC)。
Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environme...
关键词：ALKBH5 AUTOPHAGY FTO Hippo pathway m~6A Parkinson's disease RNA methylation SALSOLINOL YAP1 YTHDF2 
Cap-specific terminal N6-methyladeonsine methylation of RNA mediated by PCIF1 and possible therapeutic implications
《Genes & Diseases》2025年第1期172-181,共10页Hui Zeng Yidong Wu Xinghua Long 
supported by grants from the National Natural Science Foundation of China(No.81272372);Zhongnan Hospital of Wuhan University Science,Technology and Innovation Seed Fund(Wuhan,China)(No.PTXM2022017);The project was sponsored by SRF for ROCS,SEM.
Posttranscriptional RNA modification is an important mode of epigenetic regulation in various biological and pathological contexts.N6,2′-O-dimethyladenosine(m6Am)is one of the most abundant methylation modifications ...
关键词：Cancer m^(6)Am PCIF1 RNA modification Virus infection 
The crosstalk between cellular survival pressures and N6-methyladenosine modification in hepatocellular carcinoma
《Hepatobiliary & Pancreatic Diseases International》2025年第1期67-75,共9页Chu-Li Fu Zheng-Wei Zhao Qiang-Nu Zhang 
supported by grants from Research Founda-tion of Guangzhou Women and Children’s Medical Center for Clinical Doctor (1600110);Science and Technology Projects in Guangzhou (202201011371);Guangzhou Municipalcience and Tech-nology Bureau Foundation (2023A03J0917);Guangdong Basic and Applied Basic Research Foundation (2023A1515220076 and 2022A1515110283)。
Background:Within the tumor microenvironment,survival pressures are prevalent with potent drivers of tumor progression,angiogenesis,and therapeutic resistance.N6-methyladenosine(m6 A)methylation has been recognized as...
关键词：Hepatocellular carcinoma N6-methyladenosine methylation HYPOXIA Target therapy Survival pressure 
Improving regulatory T cell-based therapy:insights into post-translational modification regulation
《Journal of Genetics and Genomics》2025年第2期145-156,共12页Aiting Wang Yanwen Wang Rui Liang Bin Li Fan Pan 
supported by grants from the National Key R&D Program of China(2022YFC2403000 and 2021YFC2400500);the National Natural Science Foundation of China(32200728 and 32170925);the Clinical Research Project of Shenzhen Medical Academy of Research and Translation(C2301008);Shenzhen Science and Technology Program(JCYJ20220531100406014,JCYJ2022081800807016,RCBS20221008093336088,KQTD20210811090115019);Guangdong Basic and Applied Basic Research Foundation(2021A1515110375);the Innovative Research Team of High-level Local Universities in Shanghai(SHSMU-ZDCX20210601).
Regulatory T(Treg)cells are pivotal for maintaining immune homeostasis and play essential roles in various diseases,such as autoimmune diseases,graft-versus-host disease(GVHD),tumors,and infectious diseases.Treg cells...
关键词：Treg cell FOXP3 UBIQUITINATION ACETYLATION PHOSPHORYLATION METHYLATION GLYCOSYLATION Post-translational modification 
RNA methylation in neurodevelopment and related diseases
《Acta Biochimica et Biophysica Sinica》2024年第12期1723-1732,共10页Wenjuan Xia Yue Liu Jiafeng Lu Hoi-Hung Cheung Qingxia Meng Boxian Huang 
supported by the grants from the National Key Project of Research and Development Program(No.2022YFC2702901);the National Natural Science Foundation of China(Nos.92168104 and 82071720);the Jiangsu Province 333 Talent Grant(No.2022-3-2-155);the Suzhou Talent Training Program(Nos.GSWS2023012 and GSWS2020057);the Jiangsu Provincial Medical Key Discipline(Laboratory)Cultivation Unit(JSDW202214);the Suzhou key clinical diseases funding(No.LCZX202109).
Biological development and genetic information transfer are governed by genetic,epigenetic,transcriptional,and posttranscriptional mechanisms.RNA methylation,the attachment of methyl(-CH3)groups to RNA molecules,is a ...
关键词：RNA methylation NEURODEVELOPMENT N6-methyladenine(m6A) 5-methylcytidine(m5C) 
Simultaneous detection of methylation and genetic variations of BCR-ABL1 gene by nanopore Cas9-targeted sequencing
《Genes & Diseases》2024年第6期95-98,共4页Shuilian Xie Ying Yang Junjie Zhang Menglin Zhu Wang Li Mengting Li Yijian Chen Hailiang Li Weidan Lun Weelic Chong Shaogui Wan 
The Youth Jinggang Scholars Program in Jiangxi Province of China,Jiangxi Natural Science Foundation (China) (No.20232BAB216017);the National Natural Science Foundation of China (No.82200653).
The BCR-ABL1 fusion gene is a driver and hallmark of leukemia and a classic structural variant.1 Single nucleotide variations(SNVs)occurring in the ABL1gene kinase domain(KD)and aberrant DNA methylation modifications,...
关键词：TARGETED clinical THERAPEUTIC 
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