METHYLATION

作品数：692被引量：2392H指数：20
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相关机构：北京大学江苏大学附属人民医院信息科学与技术学院哈尔滨工业大学更多>>
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Epigenetic regulation of the inflammatory response in stroke
《Neural Regeneration Research》2025年第11期3045-3062,共18页Jingyi Liang Fei Yang Zixiao Li Qian Li 
supported by the National Natural Science Foundation of China,Nos.32070735(to QL),82371321(to QL),82171270(to ZL);Public Service Platform for Artificial Intelligence Screening and Auxiliary Diagnosis for the Medical and Health Industry,Ministry of Industry and Information Technology of the People's Republic of China,No.2020-0103-3-1(to ZL);the Natural Science Foundation of Beijing,No.Z200016(to ZL);Beijing Talents Project,No.2018000021223ZK03(to ZL);Beijing Municipal Committee of Science and Technology,No.Z201100005620010(to ZL)。
Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either type.Immunologic mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytoki...
关键词：DNA methylation histone modification intracerebral hemorrhage ischemic stroke NEUROINFLAMMATION NEUROPROTECTION non-coding RNA RNA methylation subarachnoid hemorrhage treatment 
Allele-specific methylation of the PSA promoter in prostate cells:A new translational marker for the differential diagnosis of prostate cancer
《Genes & Diseases》2025年第3期61-63,共3页Mikhail Baryshev Irina Maksimova Ilona Sasoveca 
supported by the internal grant of the Rıga Stradin‚s University(No.132311).
DNA methylation is one of the mechanisms of epigenetic control of gene expression,and a change in the intrinsic pattern can lead to various diseases and disorders.At the same time,this makes DNA methylation a disease-...
关键词：dna methylation prostate adenocarcinoma prostate cancer pca tumor marker allele specific methylation epigenetic control gene expressionand prostate cells psa promoter 
Multi-omics analysis reveals the epitranscriptomic and proteomic regulation network of tomato in low-temperature stress response
《Horticultural Plant Journal》2025年第2期758-773,共16页Na Wang Yanting Li Tianli Guo Libo Jiang 
financially supported by the National Natural Science Foundation of China(Grant Nos.32202518 and 32070601);Shandong University of Technology PhD Start-up Fund(418097)。
Tomato(Solanum lycopersicum)is an extensively cultivated vegetable,and its growth and fruit quality can be significantly impaired by low temperatures.The widespread presence of N^(6)-methyladenosine(m^(6)A)modificatio...
关键词：Epitranscriptome m^(6)A methylation PROTEOME Alternative polyadenylation Low temperature TOMATO 
Detecting plasma SHOX2, HOXA9, SEPTIN9, and RASSF1A methylation and circulating cancer cells for cholangiocarcinoma clinical diagnosis and monitoring
《World Journal of Gastrointestinal Oncology》2025年第4期210-222,共13页Jing Yu Qiu-Chen Liu Shuang-Yan Lu Shun Wang Hua Zhang 
Supported by the Medical Talents of Wuhan Health and Family Planning Commission,No.2017[51](to Yu J);the Medical Talents of Wuhan Hospital of Traditional Chinese and Western Medicine(to Yu J);the Hubei Natural Science Foundation,No.2023AFB1091;Wuhan Medical Research Project,No.WX23A36(to Yu J).
BACKGROUND Cholangiocarcinoma(CCA),also known as bile duct cancer,is a devastating malignancy primarily affecting the biliary tract.AIM To assess their performance in clinical diagnosis and monitoring of CCA,plasma me...
关键词：CHOLANGIOCARCINOMA METHYLATION Circulating cancer cells Diagnosis PROGNOSIS 
Buccal DNA global methylation and cognitive performance in stunted children under five years of age
《Journal of Biomedical Research》2025年第2期146-154,共9页Ahmad Rusdan Handoyo Utomo Yusnita Yusnita Siti Maulidya Sari Octaviani Indrasari Ranakusuma Sunu Bagaskara Wening Sari Yulia Suciati Anggi Puspa Nur Hidayati Silviatun Nihayah Catur Anggono Putro Neni Nurainy 
Ministry of Education,Culture,Research,and Technology of the Republic of Indonesia through the Kedaireka 2022 Matching Fund Programme(Grant No.282/E1/KS.060.02/2022)。
The prevalence of stunting in Indonesian children under five years of age is approximately 20%.Chronic maternal malnutrition contributes to the risk of stunting by affecting global DNA methylation.In the present study...
关键词：global DNA methylation 5mC ELISA STUNTING COGNITIVE 
DNMT1 promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein
《World Journal of Gastrointestinal Oncology》2025年第3期188-201,共14页Hui Xie Hui Wang Ru-Hong Li Yue-Wen Zhang Xi-Rui Fan Xiao-Xue He Ao-Ran Guan 
the Research Program of the Science and Technology Department of Yunnan Province,No.202101AY070001-204.
BACKGROUND Gastric cancer(GC)is a malignant tumor originating from gastric mucosal epithelial cells that has high morbidity and mortality.microRNAs(miR)are important diagnostic markers and therapeutic targets in this ...
关键词：Gastric cancer microRNA-125a-5p DNA methyltransferase 1 SERPINE1 METHYLATION 
SETD3-mediated histidine methylation of MCM7 regulates DNA replication by facilitating chromatin loading of MCM
《Science China(Life Sciences)》2025年第3期793-808,共16页Hongguo Duan Shuang Wang Wen-Jie Shu Yongjia Tong Hai-Zhen Long Guohong Li Hai-Ning Du Meng-Jie Zhao 
supported by the National Key Research and Development program of China(2023YF0913403);the National Natural Science Foundation of China(32200584,31971231);the Fundamental Research Funds for the Central Universities(2042022dx0003,2042022kf1048);the China Postdoctoral Science Foundation(2021M702526).
The minichromosome maintenance complex(MCM)DNA helicase is an important replicative factor during DNA replication.The proper chromatin loading of MCM is a key step to ensure replication initiation during S phase.Becau...
关键词：histidine methylation SETD3 DNA replication MCM replication origin firing 
Salsolinol as an RNA m~6A methylation inducer mediates dopaminergic neuronal death by regulating YAP1 and autophagy被引量：1
《Neural Regeneration Research》2025年第3期887-899,共13页Jianan Wang Yuanyuan Ran Zihan Li Tianyuan Zhao Fangfang Zhang Juan Wang Zongjian Liu Xuechai Chen 
supported by the National Natural Science Foundation of China,Nos.82271283(to XC),91854115(to JW),31970044(to JW);the Natural Science Foundation of Beijing,No.7202001(to XC);the Scientific Research Project of Beijing Educational Committee,No.KM202010005022(to XC)。
Salsolinol(1-methyl-6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline,Sal)is a catechol isoquinoline that causes neurotoxicity and shares structural similarity with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine,an environme...
关键词：ALKBH5 AUTOPHAGY FTO Hippo pathway m~6A Parkinson's disease RNA methylation SALSOLINOL YAP1 YTHDF2 
Cap-specific terminal N6-methyladeonsine methylation of RNA mediated by PCIF1 and possible therapeutic implications
《Genes & Diseases》2025年第1期172-181,共10页Hui Zeng Yidong Wu Xinghua Long 
supported by grants from the National Natural Science Foundation of China(No.81272372);Zhongnan Hospital of Wuhan University Science,Technology and Innovation Seed Fund(Wuhan,China)(No.PTXM2022017);The project was sponsored by SRF for ROCS,SEM.
Posttranscriptional RNA modification is an important mode of epigenetic regulation in various biological and pathological contexts.N6,2′-O-dimethyladenosine(m6Am)is one of the most abundant methylation modifications ...
关键词：Cancer m^(6)Am PCIF1 RNA modification Virus infection 
The crosstalk between cellular survival pressures and N6-methyladenosine modification in hepatocellular carcinoma
《Hepatobiliary & Pancreatic Diseases International》2025年第1期67-75,共9页Chu-Li Fu Zheng-Wei Zhao Qiang-Nu Zhang 
supported by grants from Research Founda-tion of Guangzhou Women and Children’s Medical Center for Clinical Doctor (1600110);Science and Technology Projects in Guangzhou (202201011371);Guangzhou Municipalcience and Tech-nology Bureau Foundation (2023A03J0917);Guangdong Basic and Applied Basic Research Foundation (2023A1515220076 and 2022A1515110283)。
Background:Within the tumor microenvironment,survival pressures are prevalent with potent drivers of tumor progression,angiogenesis,and therapeutic resistance.N6-methyladenosine(m6 A)methylation has been recognized as...
关键词：Hepatocellular carcinoma N6-methyladenosine methylation HYPOXIA Target therapy Survival pressure 
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