Allele-specific methylation of the PSA promoter in prostate cells:A new translational marker for the differential diagnosis of prostate cancer  

作　　者：Mikhail Baryshev Irina Maksimova Ilona Sasoveca 

机构地区：[1]Institute of Microbiology and Virology,Riga Stradins University,Ratsupites Str 5,Riga LV 1067,Latvia

出　　处：《Genes & Diseases》2025年第3期61-63,共3页基因与疾病(英文)

基　　金：supported by the internal grant of the Rıga Stradin‚s University(No.132311).

摘　　要：DNA methylation is one of the mechanisms of epigenetic control of gene expression,and a change in the intrinsic pattern can lead to various diseases and disorders.At the same time,this makes DNA methylation a disease-specific biomarker.For a long time,prostate-specific antigen(PSA)was used as an established tumor marker for prostate adenocarcinoma in the clinic for the diagnosis of prostate cancer(PCa).1 Despite the generally accepted fact that PSA is organ-but not cancer-specific,it still retains its diagnostic value for cancer detection.

关 键 词：dna methylation prostate adenocarcinoma prostate cancer pca tumor marker allele specific methylation epigenetic control gene expressionand prostate cells psa promoter 

分 类 号：R737.25[医药卫生—肿瘤]