LIPID

作品数:861被引量:1810H指数:18
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相关领域:医药卫生更多>>
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相关机构:梧州市食品药品检验所中国科学院上海医药工业研究院清华大学更多>>
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Captiva EMR-Lipid柱净化-超高效液相色谱-串联质谱法快速同时测定谷物及其制品中11种麦角生物碱
《色谱》2025年第4期326-334,共9页刘柏林 张丹 赵紫微 谢继安 詹子悦 张琪 李卫东 
麦角生物碱(EAs)是由麦角菌属(Claviceps)产生的一类真菌毒素,当人类摄入被EAs污染的谷物及其制品时,可能会遭受慢性或急性中毒,从而威胁身体健康。鉴于此,本文基于超高效液相色谱-串联质谱(UPLC-MS/MS)建立了谷物及其制品中11种EAs的...
关键词:超高效液相色谱-串联质谱 谷物及其制品 麦角生物碱 真菌毒素 
Role of metabolic dysfunction and inflammation along the liver-brain axis in animal models with obesity-induced neurodegeneration被引量:1
《Neural Regeneration Research》2025年第4期1069-1076,共8页Evridiki Asimakidou Eka Norfaishanty Saipuljumri Chih Hung Lo Jialiu Zeng 
supported by a Presidential Postdoctoral Fellowship (021229-00001) from Nanyang Technological University,Singapore (to JZ);a Lee Kong Chian School of Medicine Dean’s Postdoctoral Fellowship (021207-00001) from NTU Singapore;a Mistletoe Research Fellowship (022522-00001) from the Momental Foundaton,USA (to CHL)
The interaction between metabolic dysfunction and inflammation is central to the development of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease.Obesity-related conditions like type 2 d...
关键词:Alzheimer’s disease inflammatory cytokines insulin resistance LIPID 
Performance analysis of nanostructured lipid carriers for chemical sunscreen agents
《日用化学工业(中英文)》2025年第2期185-193,共9页Xiaoyu Li Jianping Jiang Lifeng Xiao 
广东省普通高校重点领域专项(2021ZDZX2076)。
Nanolipid carriers and traditional emulsion containing chemical sunscreens were prepared using emulsification combined with ultrasonic technology.The nanolipid carriers showed superior performance in sunscreen encapsu...
关键词:nano lipid carrier sunscreen agents PHOTOSTABILITY in vitro sustained-release properties extracorporeal permeability 
A lipid/PLGA nanocomplex to reshape tumor immune microenvironment for colon cancer therapy
《Regenerative Biomaterials》2025年第1期20-31,共12页Nan Zhang Qiqi Sun Junhua Li Jing Li Lei Tang Quan Zhao Yuji Pu Gaofeng Liang Bin He Wenxia Gao Jianlin Chen 
supported by the National Natural Science Foundation of China[52073216 and 51773130].
Immune checkpoint blockade therapy provides a new strategy for tumor treatment;however,the insufficient infiltration of cytotoxic T cells and immunosuppression in tumor microenvironment lead to unsatisfied effects.Her...
关键词:lipid/PLGA nanocomplex immune checkpoint blockade photodynamic therapy IDO inhibition colon cancer 
高效液相色谱-串联质谱法测定生乳中加米霉素残留量
《食品安全质量检测学报》2025年第3期303-308,共6页李默 赵鑫 张虹吉 周婷 王倩 赵修平 李克静 
目的建立以基质外标法定量,通过式净化柱(EMR-Lipid)结合高效液相色谱-串联质谱法(high performance liquid chromatography-tandem mass spectrometry,HPLC-MS/MS)测定生乳中加米霉素残留量的分析方法。方法样品经酸性乙腈提取后,由EMR...
关键词:加米霉素 高效液相色谱-串联质谱法 EMR-Lipid通过式净化柱 生乳 
Exploring the role of cationic lipids in modulating immunogenicity and vaccine efficacy of mRNA-LNP
《Particuology》2025年第2期1-11,共11页Yan Zhou Xiangfei Shan Renji Gu Yufei Xia Xiaonan Huang 
This work was supported by National Key Research and Development Program of China(grant No.2021YFC2302400);Major Program of the National Natural Science Foundation of China(grant Nos.T2394503 and T2394501);CAS Project for Young Scientists in Basic Research(grant No.YSBR-010);Key Project of the National Natural Science Foundation of China(grant No.32030062);IPE Project for Frontier Basic Research(grant No.QYJC2023-04)。
The mRNA vaccines have become a transformative platform in medicine,with their success during the COVID-19 pandemic accelerating research in viral prevention and cancer therapy.Lipid nanoparticles(LNPs)enhance the sta...
关键词:Lipid nanoparticle mRNA vaccine IMMUNOGENICITY Cationic lipids Immune response 
Relationship between longitudinal changes in lipid composition and ischemic stroke among hypertensive patients
《World Journal of Clinical Cases》2025年第4期18-27,共10页Cheng-Cheng Wei Yu-Qing Huang Cheng-Hong Yu 
BACKGROUND Dyslipidemia was strongly linked to stroke,however the relationship between dyslipidemia and its components and ischemic stroke remained unexplained.AIM To investigate the link between longitudinal changes ...
关键词:Longitudinal change HYPERTENSION DYSLIPIDEMIA Lipid profile Ischemic stroke 
Chemistry-driven mass spectrometry for structural lipidomics at the C=C bond isomer level
《Chinese Chemical Letters》2025年第1期225-233,共9页Junmeng Luo Qiongqiong Wan Suming Chen 
financially supported by the National Natural Science Foundation of China(No.22074111);National Key Research and Development Program of China(No.2021YFC2700700);the Opening fund of Hubei Key Laboratory of Bioinorganic Chemistry&Materia Medica(No.BCMM202303)。
As more and more studies have shown that lipid molecules play an important role in the whole biology,in-depth analysis of lipid structure has become particularly important in lipidomics.Mass spectrometry(MS),as the pr...
关键词:Mass spectrometry Structural lipidomics Lipid isomers Double bond location Double bond configuration Chemical derivatization 
Foxp3 inhibitory peptide encapsulated in a novel CD25-targeted nanoliposome promotes efficient tumor regression in mice
《Acta Pharmacologica Sinica》2025年第1期171-183,共13页Aejandro Serrano Noelia Casares lnaki F.Troconiz Teresa Lozano Juan J.Lasarte Sara Zalba Maria J.Garrido 
This research was funded by Ministry of Science;Innovation(PID2019-108989RB-100;PID2021-1282830A-00,PLEC2021-008094 MCIN/AEI/10.13039/501100011033);Gobierno de Navarra Industria(0011-1411-2022-000088;SOCRATHES project);Paula and Rodger Riney Foundation and Fundacion Bita;This work was supported by an ADA(University of Navarra)scholarship of Alejandro Serrano.
P60,a Foxp3 inhibitory peptide,can hinder the regulatory T cell(Treg)activity and impair tumor proliferation.However,low systemic stability and poor specificity have led to daily dosing to achieve therapeutic effect.T...
关键词:Treg cells CD25 lipid nanoparticle PEG chain lengths post-insertion translation approach 
Integration of perioperative features and intragraft TCF7L2 expression to predict lipid metabolic disorder in liver transplant recipients
《Science China(Life Sciences)》2025年第1期297-299,共3页Junbin Zhou Rongli Wei Guanghan Fan Zhengxing Lian Xuanyu Zhang Linsong Tang Zhetuo Qi Haiyang Xie Shusen Zheng Qiang Wei Xiao Xu 
supported by the Medical and Health Technology Program in Zhejiang Province(WKJ-ZJ-2120);the National Key Research and Development Program of China(2021YFA1100500);Major Research Plan of the National Natural Science Foundation of China(92159202);Public Welfare Technology Application Research Project of Lishui City(2023SJZC110).
Dear Editor,Liver transplantation(LT)is the only curative therapy for patients with endstage liver disease(He et al.,2023;Ling et al.,2022).Post-transplant hypertriglyceridemia(PTHT),which has an incidence of up to 32...
关键词:LIVER GRAFT 
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