Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis Ulcerative colitis  

作　　者：Eun Mi Song Jahanzeb Saqib Yang Hee Joo Zehra Ramsha Chang Mo Moon Sung-Ae Jung Junil Kim 

机构地区：[1]Departments of Internal Medicine,College of Medicine,Ewha Womans University,Seoul 07804,Republic of Korea [2]School of Systems Biomedical Science,Soongsil University,369 Sangdo-Ro,Dongjak-Gu,Seoul 06978,Republic of Korea

出　　处：《Genes & Diseases》2025年第3期72-75,共4页基因与疾病(英文)

基　　金：supported by the Basic Science Research Program through the National Research Foundation of Korea(NRF)funded by the Ministry of Education of the Republic of Korea(No.2020R1I1A1A01073545 to E.M.S.,2020R1A2C1010786 to C.M.M.,2021R1A6A1A10044154 to J.K).

摘　　要：Inflammatory transcriptomic signatures and cell type compositions in inflamed and non-inflamed colonic mucosa of ulcerative colitis Ulcerative colitis(UC),a subtype of inflammatory bowel disease,arises from disrupted gut homeostasis,primarily due to an aberrant innate immune response to intestinal microbiota and an underlying genetic background.1 Recently,complete healing of mucosal inflammation has been suggested as a new therapeutic goal in UC treatment.2 However,this goal remains challenging,as approximately 20%of individuals in clinical remission still exhibit active mucosal inflammation.3 Understanding the molecular alterations underlying this persistent mucosal inflammation is crucial for advancing UC pathogenesis insights and treatment strategies.

关 键 词：cell type compositions aberrant innate immune response intestinal microbiota colonic mucosa disrupted gut homeostasisprimarily healing mucosal inflammation ulcerative colitis uc ulcerative colitis 

分 类 号：R574.62[医药卫生—消化系统]