PACLITAXEL

作品数：362被引量：939H指数：15
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相关作者：张强刘祥瑞王坚成王金华缪静更多>>
相关机构：北京大学中国医学科学院北京协和医学院北京肿瘤医院复旦大学更多>>
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STT3-mediated aberrant N-glycosylation of CD24 inhibits paclitaxel sensitivity in triple-negative breast cancer
《Acta Pharmacologica Sinica》2025年第4期1097-1110,共14页Jun Wang Hui-min Zhang Guan-hua Zhu Li-li Zhao Ji Shi Zhou-tong Dai Jia-peng Li Xing-rui Li Fan Sun Yuan Wu Shao-yong Chen Han-ning Li Xing-hua Liao Yuan Xiang 
financially supported by the National Natural Science Foundation of China(32170578 and 82203497);Hubei Natural Science Foundation(2024AFB905 and 2024AFD011);Hubei Province Key R&D Program(2022BCA007);Department of Education Scientific Research Program guidance project(B2023014);“The 14th Five Year Plan”Hubei Provincial advantaged characteristic disciplines(groups)project of Wuhan University of Science and Technology(2023C0303);Natural Science Foundation Exploration Program of Wuhan(2024040801020310);the Hunan Natural Science Foundation(2023JJ50310 and 2023JJ50296).
Paclitaxel is one of the main chemotherapic medicines against triple-negative breast cancer(TNBC)in clinic.However,it has been perplexed by paclitaxel resistance in TNBC patients,resulting in a poor prognosis.Abnormal...
关键词：triple-negative breast cancer PACLITAXEL CD24 N-GLYCOSYLATION ferroptosis STT3 
Metabolomic and Transcriptomic Insights into Enhanced Paclitaxel Biosynthesis in Cultivated Taxus cuspidata
《Phyton-International Journal of Experimental Botany》2025年第4期1137-1158,共22页Dandan Wang Jiaxin Chen Yanwen Zhang 
supported by grants from the National Science Foundation of China to Yanwen Zhang(32272757,31972363);grants from Liaoning Provincial Department of Education Project to Dandan Wang(JYTMS20230698);grants from the Liaoning Provincial Science and Technology.Fund Project to Dandan Wang(2023JH2/101700200).
Taxus cuspidata,a rare species of the Taxus genus,and its wild resources are under severe threat.The development of cultivated species has become an important strategy to replace wild species.The objective of this wor...
关键词：T.cuspidata wild species cultivated species metabolomics TRANSCRIPTOMICS PACLITAXEL 
Efficacy of fluorouracil combined with paclitaxel and oxaliplatin for the treatment of advanced gastric signet ring cell carcinoma
《World Journal of Gastrointestinal Surgery》2025年第3期69-78,共10页Mi Liu Bei Feng Na He Rong Yan Jie Qin 
BACKGROUND Gastric signet ring cell carcinoma(GSRC)is a distinctive type of gastric cancer.It is a mucus-secreting adenocarcinoma that may progress to distant metastasis at an early stage.Because of poor differentiati...
关键词：OXALIPLATIN Tigio Carcinoembryonic antigen Carbohydrate antigen 19-9 Advanced gastric signet ring cell carcinoma 
Intratumoral injection of two dosage forms of paclitaxel nanoparticles combined with photothermal therapy for breast cancer
《Chinese Herbal Medicines》2025年第1期156-165,共10页Lina Sun Cuiling Zuo Baonan Ma Xinxin Liu Yifei Guo Xiangtao Wang Meihua Han 
financially supported by CAMS Innovation Fund for Medical Sciences(CIFMS,No.2021-I2M-1-031,No.2021-I2M1-071)。
Objective:In order to enhance the efficacy of anti-breast cancer,paclitaxel nanoparticles(PTX NPs)and polypyrrole nanoparticles(PPy NPs)were combined with photothermal therapy and chemotherapy.At the same time,the two...
关键词：breast cancer combination therapy PACLITAXEL photothermal therapy POLYPYRROLE 
Salidroside Enhances the Sensitivity of Lung Cancer Cells to Paclitaxel by Regulating the Wnt/β-catenin Signaling Pathway
《Current Medical Science》2025年第1期104-113,共10页Guo-liang Pi Liang-hao Cheng Bin-feng Li Fei Ming 
supported by the Scientific Research Project of Hubei Cancer Hospital(No.2024HBCHYN08);the Natural Science Foundation of Hubei Province(No.2023AFB988);the Scientific Research Project in the Field of Oncology(No.FB2024025225);the Talent Project of Hubei Cancer Hospital(No.2025HBCHHHRC007).
Objective Chemoresistance,such as paclitaxel(PTX)resistance,has become a great obstacle in non-small cell lung cancer(NSCLC)treatment.The natural agent salidroside(SAL)has been shown to exert an antitumor effect on NS...
关键词：Lung cancer SALIDROSIDE Drug resistance PACLITAXEL WNT/Β-CATENIN 
Self-assembled co-delivery system of gold nanoparticles and paclitaxel based on in-situ dynamic covalent chemistry for synergistic chemo-photothermal therapy
《Rare Metals》2025年第1期417-429,共13页Xiao-Xia Wu Ding-Hu Zhang Yi-Nan Ding Fei Cao Yang Li Jun-Lie Yao Xin-Yu Miao Lu-Lu He Jun Luo Jian-Wei Li Jie Lin Ai-Guo Wu Jia-Ping Zheng 
supported by the National Natural Science Foundation of China(Nos.82202274,82072032,22161016,32025021,12374390,52002380 and 31971292),the National Science and Technology Major Project(No.2023ZD0500902);the Fellowship of China Postdoctoral Science Foundation(No.2023M743559);the Member of Youth Innovation Promotion Association Foundation of CAS,China(No.2023310);the Key Scientific and Technological Special Project of Ningbo City(No.2023Z209);the Natural Science Foundation of Zhejiang Province(No.LQ23H180003)。
Recently,stimuli-responsive nanocarriers capable of precision drug release have garnered significant attention in the field of drug delivery.Here,an in-situ dynamic covalent self-assembled(DCS)strategy was utilized to...
关键词：in-situ dynamic covalent self-assembly(DCS) Disulfide macrocycles Host-guest interaction Glutathione(GSH)stimuli-response Chemo-photothermal therapy 
Adverse Reactions Such as Fecal Incontinence Occurred in 1 Patient with Ovarian Cancer Induced by Paclitaxel Liposome Allergy
《Journal of Biosciences and Medicines》2025年第1期41-46,共6页Gaijing Wang Haimei Ren Ziyi Liu Jing Wang Lei Su Miaomiao Song Yanling Li Yuanyuan Yang Jiale Lu Zhihui Cai Jie Cui 
Paclitaxel is one of the commonly used drugs in postoperative chemotherapy for ovarian cancer patients. However, affected by drug dosage and individual differences in the course of medication, patients will have diffe...
关键词：PACLITAXEL Drug Allergy Adverse Reactions Ovarian Cancer 
Paclitaxel for second-line treatment of squamous cell carcinoma of the head and neck:A multicenter retrospective Italian study
《World Journal of Clinical Oncology》2024年第12期1468-1480,共13页Morena Fasano Mario Pirozzi Pasquale Vitale Vincenzo Damiano Graziana Ronzino Stefano Farese Vincenzo Carfora Giuseppina Ciccarelli Ilaria Di Giovanni Sergio Facchini Gregorio Cennamo Michele Caraglia Fortunato Ciardiello Raffaele Addeo 
BACKGROUND Squamous cell carcinoma of the head and neck(SCCHN)accounts for 3%of all malignant tumors in Italy.Immune checkpoint inhibitors combined with chemotherapy is first-line treatment for SCCHN;however,second-li...
关键词：TAXANES Immunotherapy Head and neck cancer Alcohol SMOKING Body mass index 
Biochemical synthesis of taxanes from mevalonate
《Synthetic and Systems Biotechnology》2024年第4期694-700,共7页Jing Li Xiaonan Liu Xiaoxi Zhu Jiayu Liu Lei Zhang Nida Ahmed Jian Qi Bihuan Chen Daliang Tang Jinsheng Yu Zhijin Fan Huifeng Jiang 
supported in part by the National Natural Science Foundation of China(32371499,31901026 and 32172443),China Postdoctoral Science Foundation(2019M661032);National Key R&D Program of China(2020YFA0908000 and 2022YFD1700400);the Frontiers Science Center for New Organic Matter,Nankai University(63181206);he Tianjin Development Program for Innovation and Entrepreneurship(2019-06).
Taxanes are kinds of diterpenoids with important bioactivities,such as paclitaxel(taxol®)is an excellent natural broad-spectrum anticancer drug.Attempts to biosynthesize taxanes have made with limited success,mainly d...
关键词：Biochemical synthesis TAXANES PACLITAXEL Modular synthesis 
Cancer nuclear envelope rupture and repair in taxane resistance
《Medical Review》2024年第6期522-530,共9页Ana P.Xu Lucy B.Xu Elizabeth R.Smith Joshua S.Fleishman Zhe-Sheng Chen Xiang-Xi Xu 
partially supported by NIH funding R01 CA095071,CA79716,and CA75389 to XX from NCI,NIH;seed funding from Sylvester Comprehensive Cancer Center,University of Miami.
Taxanes,including paclitaxel,docetaxel,and cabazitaxel,are key agents in cancer treatment,often used as frontline chemotherapy drugs in combination with other agent(s)(commonly carboplatin)and as second-line treatment...
关键词：chemotherapy drug resistance TAXANES PACLITAXEL MICROTUBULES nuclear envelope 
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