Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,...
Hydroxychloroquine(HCQ)is widely used in the treatment of autoimmune disorders such as systemic lupus erythematosus(SLE)and rheumatoid arthritis,and in recent years it has also been used in diseases such as cancer,neu...
INTRODUCTION A hydatidiform mole is a disease that occurs due to abnormal proliferation of the trophoblastic epithelium and placental villous oedema,included in the spectrum of gestational trophoblastic diseases(GTD)....
supported by the National Natural Science Foundation of China(grant number 82371139,82371138,82101210 and 82171131);Beijing Hospital Authority Youth Program(grant number QML20230121).
The inner ear sensory epithelium consists of two major types of cells:hair cells(HCs)and supporting cells(SCs).Critical functions of HCs in the perception of mechanical stimulation and mechanosensory transduction have...
supported by institutional funds from the University of Zurich(T.A.M)and from the Knut and Alice Wallenberg Foundation(C.C.);by additional competitive funds from the Swiss National Science Foundation(SNSF;research grant 31003A_179389)(T.A.M.);from the Swiss Dental Association(SSO;research grant 313-19)(T.A.M.,P.P.)。
Neurite outgrowth inhibitor A(Nogo-A)is a major player in neural development and regeneration and the target of clinical trials aiming at promoting the regeneration of the central nervous system upon traumatic and isc...
supported by grants from the National Natural Science Foundation of China(82201079);the Natural Science Foundation of Hunan Province,China(2023JJ40881);the Major Project of Natural Science Foundation of Hunan Province(Open Competition,2021JC0002);the Fundamental Research Funds for the Central Universities of Central South University(2023ZZTS0582)。
Oral submucous fibrosis(OSF)is a chronic and inflammatory mucosal disease caused by betel quid chewing,which belongs to oral potentially malignant disorders.Abnormal fibroblast differentiation leading to disordered co...
Natural Science Foundation of Jiangxi Province(20224ACB209001).
Intestinal epithelium regeneration is crucial for homeostatic maintenance of the intestinal functions.A recent study published in Nature uncovers tuft cells as an unexpected key player in the regenerative process.Huma...
the National Natural Science Foundation of China(No.81900958,82170987,82073378,81974146,82101053);the Natural Science Foundation of Guangdong Province,China(No.2020A1515-010059,2021A1515012535);Sun Yat-Sen University Clinical Research 5010 Program(No.2023009);Science and Technology Planning Project of Guangzhou,China(No.2023-A04J2148);Open Funding of Guangdong Provincial Key Laboratory of Stomatology(China)(No.KF2021120104).
Developmental defects of enamel are common due to genetic and environmental factors before and after birth.Cdc42,a Rho family small GTPase,regulates prenatal tooth development in mice.However,its role in postnatal too...
supported by the National Key R&D Program of China(2022YFC3602003);the National Key R&D Program of China(2021YFC2301804);the Zhejiang Provincial Natural Science Foundation(LZ22H030001).
Intestinal microbiota is an indispensable part of intestinal homeostasis and is closely related to human health.Intestinal microbiota participates in the development of a variety of intestinal diseases in a complex an...
Wound-healing diseases present complex challenges,and proliferative vitreoretinopathy(PVR)has been a problem in the surgical retina for 50y.PVR is a prolonged and abnormal healing response to retinal injury,such as pr...