Tuft cells promote human intestinal epithelium regeneration as reserve stem cells after irradiation  

作　　者：Yehua Li Mengxian Zhang Xianrun Ma Ye‑Guang Chen 

机构地区：[1]Institute of Biomedical Innovation,School of Basic Medical Sciences,Jiangxi Medical College,Nanchang University,Nanchang 330031,China [2]The State Key Laboratory of Membrane Biology,Tsinghua‑Peking Center for Life Sciences,School of Life Sciences,Tsinghua University,Beijing 100084,China

出　　处：《Cell Regeneration》2024年第1期58-60,共3页细胞再生(英文)

基　　金：Natural Science Foundation of Jiangxi Province(20224ACB209001).

摘　　要：Intestinal epithelium regeneration is crucial for homeostatic maintenance of the intestinal functions.A recent study published in Nature uncovers tuft cells as an unexpected key player in the regenerative process.Human tuft cells,traditionally recognized for their involvement in immune defense and pathogen protection,were found to exhibit stem cell-like properties following radiation-induced injury.These cells not only resist damage but also have the abil-ity to generate functional stem cells,promoting the repair of the intestinal epithelium.This finding suggests that tuft cells may function as a reserve pool of stem cells,essential for efficient intestinal regeneration after injury.

关 键 词：EPITHELIUM INVOLVEMENT traditionally 

分 类 号：R57[医药卫生—消化系统]