Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders  

作　　者：Victor V.Chizhikov Igor Y.Iskusnykh 

机构地区：[1]Department of Anatomy and Neurobiology,University of Tennessee Health Science Center,Memphis,TN,USA

出　　处：《Neural Regeneration Research》2025年第4期1079-1080,共2页中国神经再生研究（英文版）

基　　金：supported by R01 NS093009 grant from NIH(to VVC).

摘　　要：Development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical neuroepithelium.One such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in mice.The cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)proteins.The cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;Dal-Valle-Anton and Borrell,2022).

关 键 词：EPITHELIUM FIGURE CENTER 

分 类 号：R741[医药卫生—神经病学与精神病学]