Unraveling Interactions Between Gut Epithelium and Microbiota Using Models of Intestinal Organoids  

作　　者：Yi Huang Kangxin He Yanfei Chen 

机构地区：[1]State Key Laboratory for Diagnosis and Treatment of Infectious Diseases,National Clinical Research Center for Infectious Diseases,National Medical Center for Infectious Diseases,Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou,China

出　　处：《Infectious Microbes & Diseases》2024年第3期117-126,共10页感染微生物与疾病（英文）

基　　金：supported by the National Key R&D Program of China(2022YFC3602003);the National Key R&D Program of China(2021YFC2301804);the Zhejiang Provincial Natural Science Foundation(LZ22H030001).

摘　　要：Intestinal microbiota is an indispensable part of intestinal homeostasis and is closely related to human health.Intestinal microbiota participates in the development of a variety of intestinal diseases in a complex and diverse manner.Previous results have confirmed microbiota dysbiosis in a variety of diseases,while the mechanism is not clear.It is valuable to unravel these complex mechanisms,which would guide future therapies.A limiting factor of studies exploring interaction mechanisms between gut epithelium and microbiota was a lack of an in vitro organ model.The development of organoids has provided an indispensable tool for gastrointestinal studies.Here,we review the applications of organoids in exploring the roles of gut microbiota and its metabolites in diseases,summarize the advantages and limitations of organoid models,and discuss future prospective and challenges in this area.

关 键 词：ORGANOIDS gut microbiota interaction gut epithelium 

分 类 号：R574[医药卫生—消化系统]