EPIGENETICS

作品数：553被引量：2052H指数：19
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相关领域：医药卫生更多>>
相关作者：孙树汉王越郭瀛军杨富王树人更多>>
相关机构：第二军医大学四川大学北京大学复旦大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金中国博士后科学基金更多>>
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Biomarkers for tracking metabolic changes pre-post nutritional epigenetics diet/intervention to prevent autism and attention deficit/hyperactivity disorders in children
《World Journal of Experimental Medicine》2025年第2期12-23,共12页Renee J Dufault 
The prevalence of autism and attention deficit/hyperactivity disorders is increasing worldwide.Recent studies suggest the excessive intake of ultra-processed food plays a role in the inheritance of these disorders via...
关键词：Mercury Lead AUTISM Attention deficit/hyperactivity disorder METALLOTHIONEIN Nutritional epigenetics Zinc 
Use of DNA methylation patterns for early detection and management of lung cancer:Are we there yet?
《Oncology Research》2025年第4期781-793,共13页MILICA KONTIC FILIP MARKOVIC 
Detecting lung cancer early is crucial for improving survival rates,yet it remains a significant challenge due to many cases being diagnosed at advanced stages.This review aims to provide advances in epigenetics which...
关键词：Lung cancer DNA methylation EPIGENETICS HYPERMETHYLATION Early detection 
The Role of Linker Histone Mutation in Oncogenesis: Molecular Mechanism and Structural Impact
《BIOCELL》2025年第4期519-538,共20页Gege Liu Houfang Zhang Yunhui Peng 
supported by the National Natural Science Foundation of China(No.12205112);financially supported by self-determined research funds of CCNU from the colleges’basic research and operation of MOE(CCNU24JC012);supported by Natural Science Foundation of Wuhan(No.2024040801020302).
Nucleosomes play a vital role in chromatin organization and gene regulation,acting as key hubs that inter-act with various chromatin-associated factors through diverse binding mechanisms.Recent research has highlighte...
关键词：Linker histone H1 EPIGENETICS histone cancer mutations chromatin structure NUCLEOSOME 
Despicable role of epithelial-mesenchymal transition in breast cancer metastasis:Exhibiting de novo restorative regimens
《Cancer Pathogenesis and Therapy》2025年第1期30-47,共18页Paras Famta Saurabh Shah Biswajit Dey Kondasingh Charan Kumar Deepkumar Bagasariya Ganesh Vambhurkar Giriraj Pandey Anamika Sharma Dadi ASrinivasarao Rahul Kumar Santosh Kumar Guru Rajeev Singh Raghuvanshi Saurabh Srivastava 
Breast cancer(BC)is the most prevalent cancer in women globally.Anti-cancer advancements have enabled the killing of BC cells through various therapies;however,cancer relapse is still a major limitation and decreases ...
关键词：BREASTCANCER Epithelial-to-mesenchymal transition METASTASES Cancer stem cells EPIGENETICS 
Dietary modulation of epigenetics:Implications for cancer prevention and progression
《Journal of Nutritional Oncology》2025年第1期8-15,共8页Si-Rui Zhu Xin-Yu Liang Qian Bai Xiang-Min Ni Jian Wang 
Epidemiological studies indicate a strong correlation between various types of human cancer and dietary factors,whereas the specific mechanisms remain to be fully elucidated.Epigenetic alterations,such as DNA methylat...
关键词：EPIGENETIC DNA methylation Histone modification Cancer DIET 
Epigenetic variation in maize agronomical traits for breeding and trait improvement Author links open overlay panel
《Journal of Genetics and Genomics》2025年第3期307-318,共12页Daolei Zhang Yujun Gan Liang Le Li Pu 
supported by funding from the National Key R&D Program of China(2023ZD0407304);the Sci-Tech Innovation 2030 Agenda(2022ZD0115703);Fundamental Research Funds for Central Non-Profit of Chinese Academy of Agricultural Sciences(Y2023PT20).
Epigenetics-mediated breeding(epibreeding)involves engineering crop traits and stress responses through the targeted manipulation of key epigenetic features to enhance agricultural productivity.While conventional bree...
关键词：Epibreeding Epigenetic variation Agronomical traits Epigenome editing Synthetic epigenetics 
The comprehensive assessment of epigenetics changes during skin development
《Fundamental Research》2025年第1期228-240,共13页Li Lei Ling Jiang Yibo Hu Menglu Chen Jinhua Huang Jing Chen Qinghai Zeng 
supported by the National Natural Science Foundation of China(82073421 and 82003326);the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University(YX202007);the science and technology innovation Program of Hunan Province(2021RC3035);Natural Science Foundation of Hunan Province(2021JJ40924 and 2021JJ20089).
Epigenetic regulation is critical to multiple physiological and pathological processes.However,little is known regarding the epigenetic changes during neonatal skin development and skin aging,and in response to ultrav...
关键词：EPIGENETICS Skin development AGING ULTRAVIOLET m^(6)A 
Epigenetics disruptions enabled by porphyrin-derived metal-organic frameworks disarm resistances to sonocatalytic ROS anti-tumor actions
《Fundamental Research》2025年第1期296-306,共11页Yan Zhang Dou Du Chao Fang Xin Yu Yujia Fang Xinyu Liu Di Ou Haohao Yin Hui Liu Taixia Wang Lu Lu Xiaolong Li Kun Zhang 
supported by the Excellent Young Scientists Fund of National Natural Science Foundation of China(82022033);National Natural Science Foundation of China(81901753 and 82001820);Shanghai Rising-Star Program(19QA1406800);Shanghai Talent Development Fund(2019040);the Fundamental Research Funds for the Central Universities(22120210561);the program for Shanghai Young Top-Notch Talent.
Post-transcriptional epigenetic modifications provide numerous implications for tumor progression,metastasis and recurrence,which also pose resistances to reactive oxygen species(ROS)-based anti-tumor.Herein,we propos...
关键词：Epigenetics engineering Ubiquitylation modulation SONOCATALYSIS Reactive oxygen species resistance Anti-tumor action 
Epigenetic basis for the establishment of ruminal tissue-specific functions in bovine fetuses and adults
《Journal of Genetics and Genomics》2025年第1期78-92,共15页Jing Wang Wen Yuan Fang Liu Guangbo Liu Xiaoxiong Geng Chen Li Chenchen Zhang Nan Li Xueling Li 
funded by the Science and Technology Major Project of the Inner Mongolia Autonomous Region of China to the State Key Laboratory of Reproductive Regulation(2023KYPT0010 and 2021ZD0048);STI 2030-Major Projects(2023ZD0407504)of China;the development plan for young scientific and technological talents in colleges and universities of Inner Mongolia Autonomous Region of China(NMGIRT2204);the National Natural Science Foundation of China(32160172).
Epigenetic regulation in the rumen,a unique ruminant organ,remains largely unexplored compared with other tissues studied in model species.In this study,we perform an in-depth analysis of the epigenetic and transcript...
关键词：RUMEN EPIGENETICS DNA methylation tsDMRs ENHANCERS 
Methyltransferase DNMT3B promotes colorectal cancer cell proliferation by inhibiting PLCG2
《Acta Biochimica et Biophysica Sinica》2024年第12期1848-1859,共12页Yong Ji Yang Wang Jiacheng Zou Guanghao Liu Mingyu Xia Jun Ren Daorong Wang 
supported by the grants from the National Natural Science Foundation of China(No.81972269);the Key Laboratory of Basic and Clinical Transformation of Digestive and Metabolic Diseases,Yangzhou,China(No.YZ2020159);the Application of Fluorescence Imaging in Minimally Invasive Surgery for Low Rectal Cancer(No.ZD2022047).
Aberrant DNA methylation patterns in the promoter region of PLCG2 are associated with dysregulated signaling pathways and cellular functions.Its role in colorectal cancer cells is still unknown.In this study,qRT-PCR i...
关键词：EPIGENETICS DNA methylation DNMT3B PLCG2 colorectal cancer 
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