The comprehensive assessment of epigenetics changes during skin development  

作　　者：Li Lei Ling Jiang Yibo Hu Menglu Chen Jinhua Huang Jing Chen Qinghai Zeng 

机构地区：[1]Department of Dermatology,Third Xiangya Hospital,Central South University,Changsha 410013,China

出　　处：《Fundamental Research》2025年第1期228-240,共13页自然科学基础研究(英文版)

基　　金：supported by the National Natural Science Foundation of China(82073421 and 82003326);the Wisdom Accumulation and Talent Cultivation Project of the Third Xiangya Hospital of Central South University(YX202007);the science and technology innovation Program of Hunan Province(2021RC3035);Natural Science Foundation of Hunan Province(2021JJ40924 and 2021JJ20089).

摘　　要：Epigenetic regulation is critical to multiple physiological and pathological processes.However,little is known regarding the epigenetic changes during neonatal skin development and skin aging,and in response to ultraviolet(UV)exposure.The transcriptomes of human skin samples from different ages or irradiated with different types and doses of UV light were analyzed using R(version 4.0.3)software.The epigenetic landscape of the skin,including histone modifications,genetic imprinting and m^(6)A modification,which are mainly involved in collagen formation,extracellular matrix organization,immune function and keratinization,underwent significant changes during neonatal to adult development.Epigenetic effectors such as IGF2BP2,GATA2,GATA3,CPA4 and CDK1 were significantly correlated with extracellular matrix organization,and VEGFA,CDK1 and PRKCB with skin immune function.The m^(6)A readers such as IGF2BP2,IGF2BP3,HNRNPA2B1 and EIF3G showed significant correlation with extracellular matrix organization,metabolism,or antigen processing and presentation.Small doses of UV exposure only induced changes in the expression levels of some epigenetic effectors,without any significant effect on the overall epigenetic landscape.However,the minimal erythema dose of UV exposure altered multiple epigenetic effectors regulating extracellular matrix organization,cell-matrix adhesion,innate immune response,mitochondrial function and mRNA processing.In addition,epigenetic changes following UV exposure were more pronounced in the elderly skin compared to the younger skin.In conclusion,histone modifications,genetic imprinting and m^(6)A modification play critical roles during skin development,and a large dose of UV exposure can significantly change the expression of multiple epigenetic effectors.

关 键 词：EPIGENETICS Skin development AGING ULTRAVIOLET m^(6)A 

分 类 号：R73[医药卫生—肿瘤]