National Key Research and Development Program of China(2023YFD1301603);Agricultural Science and Technology Innovation Program of Chinese Academy of Agricultural Sciences(CAAS-ZDRW202305).
As the global population continues to expand,the demand for broiler chicken production to supply safe and high-quality meat is increasing.To meet this ever-growing demand,broiler chickens with enhanced growth performa...
This research was supported by the National Natural Science Foundation of China(grant no.32200242 to X.Y.);funds from the National Key Laboratory of Agricultural Microbiology(grant no.AML2023B07 to X.Y.);the National Natural Science Foundation of China(grant no.32130087 to D.J.);the Earmarked Fund for CARS-12(to D.J.);Fundamental Research Funds for the Central Universities(grant no.2662023PY006 and2662023ZKPY001toB.L).
Effective plant defense against pathogens relies on highly coordinated regulation of immune gene expression.Enhancers,as cis-regulatory elements,are indispensable determinants of dynamic gene regulation,but the molecu...
funded by the Science and Technology Major Project of the Inner Mongolia Autonomous Region of China to the State Key Laboratory of Reproductive Regulation(2023KYPT0010 and 2021ZD0048);STI 2030-Major Projects(2023ZD0407504)of China;the development plan for young scientific and technological talents in colleges and universities of Inner Mongolia Autonomous Region of China(NMGIRT2204);the National Natural Science Foundation of China(32160172).
Epigenetic regulation in the rumen,a unique ruminant organ,remains largely unexplored compared with other tissues studied in model species.In this study,we perform an in-depth analysis of the epigenetic and transcript...
supported by the National Key R&D Program of China(Grant No.2021YFF1000601);the Hubei Provincial Natural Science Foundation(Grant No.2023AFB1085);the Wuhan Science and Technology Major Project on Key Techniques of Biological Breeding and Breeding of New Varieties(Grant No.2022021302024853);the National Natural Science Foundation of China(Grant Nos.31772563,31790414,and 31771402);the Fundamental Research Funds for the Central Universities(Grant No.2662014PY067).
Chromatin organization is important for gene transcription in pig genome.However,its three-dimensional(3D)structure and dynamics are much less investigated than those in human.Here,we applied the long-read chromatin i...
supported by the National Key R&D Program of China(2021YFD1201300 to Y.L.and 2021YFA1300404 to J.-K.Z.);the Shanghai Agricultural Science and Technology Innovation Program of China(K2023001 to Y.L.);the National Natural Science Foundation of China(32070396 to Y.L.and 32188102 to J.-K.Z.).
Geneupregulation through genome editing is important for plant research and breeding.Targeted insertion of short transcriptional enhancers(STEs)into gene promoters may offer a universal solution akin to transgene-medi...
supported by the National Natural Science Foundation of China(No.31972367);the Science and Technology Program of Yangjiang(No.yangketong[2021]50);the Provincial Rural Revitalization Strategy Special Project of Guangdong in 2022(No.2022-NPY-00-034),China.
Objectives:Myeloblastosis(MYB)proteins,recognized as crucial transcriptional regulators,play an integral role in orchestrating the range of plant colors.Materials and Methods:Pitaya(Hylocereus spp.),a distinctive comm...
Most food flavours have been shown to contain high quantities of cooking salt, followed by flavour enhancers such as sodium glutamate, disodium inosinate, disodium guanylate and hydrogenated oils. Excess of these subs...
Long-range interactions between regulatory elements and gene promoters play key roles in transcriptional regulation.The vast majority of interactions are uncharted,constituting a major missing link in understanding ge...
supported by the grants from the Key Program of Sichuan Province Natural Science Foundation(Grant No.2022NSFSC0015);the Key R&D Program of Sichuan Province(Grant Nos.2021YFN0034 and 2021YFG0028),China.
Enhancers are DNA sequences that can strengthen transcription initiation.However,the global identification of plant enhancers is complicated due to uncertainty in the distance and orientation of enhancers,especially i...
supported by the National Natural Science Foundation of China(Grant No.82273879)
Overlook of chiral consideration in transdermal drug delivery increases administrated dose and risk of side effects,decreasing therapeutical effects.To improve the transdermal delivery efficiency of eutomer,this work ...