NANOCARRIERS

作品数：143被引量：336H指数：9
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相关领域：医药卫生一般工业技术更多>>
相关作者：赵燕军姚远马永正徐培曹诗林更多>>
相关机构：天津大学香港理工大学华南理工大学北京大学更多>>
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Enhancing the therapeutic efficacy of photodynamic therapy in colon cancer based on an ECN-mediated targeted drug delivery strategy
《Nano Research》2025年第3期417-428,共12页Kai Wang Huihui Bian Tao Ye Fusheng Shang Chenxi Zhang Dagui Chen Li Su Heng Yin Liang Zhao 
supported in part by grants from the National Natural Science Foundation of China(No.81981340417 to L.S.,No.81973878 to H.Y.);the Foundation of Shanghai Municipal Commission of Science and Technology(No.21S21901700);the Foundation of Jiangsu CM Clinical Innovation Center of Degenerative Bone&Joint Disease(Jiangsu science and education of traditional Chinese medicine[2021]No.4).
Photodynamic therapy(PDT)has attracted considerable interest in tumor treatment due to its precise temporal and spatial control.However,the off-target effects of photosensitizers and the hypoxic tumor microenvironment...
关键词：NANOCARRIERS photodynamic therapy Escherichia coli Nissle 1917 targeted drug delivery cancer therapy 
Silicon-based metal-organic frameworks(SiMOFs)for immunogenic cell death in cancer therapy
《Nano Research》2025年第1期628-641,共14页Min Han Zishan Chen Shiying Zhou Zunde Liao Xiangting Yi Yao He Yiling Zhong Kam W.Leong 
support from the Basic and Applied Basic Research Foundation of Guangdong Province,China(No.2021A1515220001).
Silicon-based nanomaterials,known for their unique properties and favorable biocompatibility,significantly impact sectors like energy,electronics,and biomedicine.Recently,metalorganic frameworks(MOFs)have emerged as p...
关键词：silicon-based nanomaterials NANOCARRIERS immunogenic cell death antitumor immune responses 
Biomimetic cell membrane decorated ZIF-8 nanocarriers with IR-780 and doxorubicin loading for multiple myeloma treatment
《Aggregate》2024年第6期332-339,共8页Guangtao Gao Junyi Che Peipei Xu Bing Chen Yuanjin Zhao 
National Key Research and Development Program of China,Grant/Award Number:2022YFA1105304;National Natural Science Foundation of China,Grant/Award Numbers:32201088,82273954;Natural Science Foundation of Jiangsu Province,Grant/Award Number:BK20210010;Fundings for Clinical Trials from the Affiliated Drum Tower Hospital,Medical School of Nanjing University,Grant/Award Number:2022-LCYJ-MS-16。
Several therapeutic drugs including heptamethine cyanine dye(IR-780),doxorubicin(DOX),and others have exhibited positive outcomes in the treatment of multiple myeloma(MM).However,curing MM is still hampered by undesir...
关键词：BIOMIMETIC bone marrow homing cell membrane drug delivery multiple myeloma PDT/PTT 
Improving treatment for Parkinson’s disease:Harnessing photothermal and phagocytosis-driven delivery of levodopa nanocarriers across the blood-brain barrier
《Asian Journal of Pharmaceutical Sciences》2024年第6期163-179,共17页Kaili Liang Li Yang Jiawei Kang Bo Liu Ding Zhang Liyan Wang Wei Wang Qing Wang 
Parkinson’s disease(PD)poses a significant therapeutic challenge,mainly due to the limited ability of drugs to cross the blood-brain barrier(BBB)without undergoing metabolic transformations.Levodopa,a key component o...
关键词：LEVODOPA Oxidative stress Blood-brain barrier Photothermal effect PHAGOCYTOSIS 
Natural-derived porous nanocarriers for the delivery of essential oils被引量：1
《Chinese Journal of Natural Medicines》2024年第12期1117-1133,共17页CHEN Hongxin SU Xiaoyu LUO Yijuan LIAO Yan WANG Fengxia HUANG Lizhen FAN Aiguo LI Jing YUE Pengfei 
supported by the National Natural Science Foundation of China (Nos. 82474087, 82274108);the Young Qihuang Scholar Program of Traditional Chinese Medicine of the State (No. 2022256);Jiangxi University of Chinese Medicine Science and Technology Innovation Team Development Program (No.CXTD22006);Jiangxi Province 2023 Graduate Innovation Special Fund Project (No. YC2023-S793)。
Essential oils(EOs) are natural, volatile substances derived from aromatic plants. They exhibit multiple pharmacological effects, including antibacterial, anticancer, anti-inflammatory, and antioxidant properties, wit...
关键词：Essential oils Natural-derived porous nanoclays Delivery Engineering strategies Application 
The size-switchable microspheres co-loaded with RANK siRNA and salmon calcitonin for osteoporosis therapy
《Chinese Chemical Letters》2024年第12期214-220,共7页Xueyan Zhang Jicong Chen Songren Han Shiyan Dong Huan Zhang Yuhong Man Jie Yang Ye Bi Lesheng Teng 
supported by the National Natural Science Foundation of China(Nos.82003687,52203138);supported by the Jilin Scientific and Technological Development Program(No.20200201415JC);supported by the Finance Project of Jilin Province;China(Nos.2019SRCJ016,2020SCZT036)。
Osteoporosis is a disease of bone metabolism homeostasis imbalance with obvious bone loss,damage to bone microstructure,and increased risk of fracture.The occurrence and development of osteoporosis is related to the a...
关键词：OSTEOPOROSIS RANK siRNA Salmon calcitonin NANOCARRIERS Size-switchable microspheres 
Viral and nonviral nanocarriers for in vivo CRISPR-based gene editing
《Nano Research》2024年第10期8904-8925,共22页Zhongyuan Guo Audrey T.Zhu Ronnie H.Fang Liangfang Zhang 
supported by the Defense Threat Reduction Agency Joint Science and Technology Office for Chemical and Biological Defense(No.HDTRA1-21-1-0010);the National Institutes of Health(Nos.R21AI159492,and R21AI175904).
The continued development of clustered regularly interspaced short palindromic repeats(CRISPR)technology has the potential to greatly impact clinical medicine,particularly for disease diagnosis and treatment.Despite h...
关键词：clustered regularly interspaced short palindromic repeats(CRISPR) in vivo gene editing NANOCARRIERS recombinant adeno-associated viruses(rAAVs) virus-like particle(VLP) lipid nanoparticle(LNP) 
Exosome-biomimetic nanocarriers for oral drug delivery被引量：1
《Chinese Chemical Letters》2024年第9期65-71,共7页Fengjie Liu Fansu Meng Zhenjiang Yang Huan Wang Yuehong Ren Yu Cai Xingwang Zhang 
supported by Guangdong Basic and Applied Basic Research Foundation(No.2023A1515012326);Major International(Regional)Joint Research Project of National Natural Science Foundation of China(No.82020108033);Science and Technology Projects in Guangzhou(No.202103000091);Sanming Project of Medicine in Shenzhen(No.202211003)。
Exosomes as authigenous nanovesicles secreted by living cells represent a significant class of biomaterials.By virtue of their unique roles in intercellular communication,exosomes can mediate intercellular information...
关键词：EXOSOMES Oral delivery Biomimetic nanocarriers Targeting BIOAVAILABILITY 
Enzyme-activatable disk-shaped nanocarriers augment tumor permeability for breast cancer combination therapy
《Nano Research》2024年第7期6400-6410,共11页Hanming Zhang Honglin Gao Yicong Zhang Yikun Han Qing Lin Tao Gong Xun Sun Zhirong Zhang Ling Zhang Shiqi Huang 
The Regional Innovation and Development Joint Fund(No.U20A20411);the National Science Fund for Excellent Young Scholars(No.82022070)provided funding for this work。
Unique physiopathological characteristics of tumor tissues impose obstacles to the sufficient penetration of traditional nanomedicines,resulting in undesirable drug delivery efficacy and therapeutic outcomes.Here,we c...
关键词：tumor penetration combination therapy charge reversal γ-glutamyl transpeptidase nanodisk 
Julolidinyl aza-BODIPYs as NIR-Ⅱ fluorophores for the bioimaging of nanocarriers被引量：1
《Acta Pharmaceutica Sinica B》2024年第7期3155-3168,共14页Chang Liu Yifan Cai Zichen Zhang Yi Lu Quangang Zhu Haisheng He Zhongjian Chen Weili Zhao Wei Wu 
supported by the National Natural Science Foundation of China(Nos.82273867 and 82030107);the Science and Technology Commission of Shanghai Municipality(No.21430760800,China).
The aggregation-caused quenching(ACQ)rationale has been employed to improve the fluorescence imaging accuracy of nanocarriers by precluding free probe-derived interferences.However,its usefulness is undermined by limi...
关键词：3 5-Julolidinyl Aza-BODIPY NANOCARRIERS Near-infraredⅡ Fluorescence imaging Aggregation-caused quenching Polymeric micelles Polymeric nanoparticles 
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