LEVODOPA

作品数：53被引量：95H指数：6
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相关领域：医药卫生更多>>
相关作者：刘畅冀希炜李健王思媛邵雪岩更多>>
相关机构：中国医学科学院北京协和医学院北京大学更多>>
相关期刊：《International Journal of Ophthalmology(English edition)》《Chinese Medical Journal》《Advances in Parkinson's Disease》《Advanced Fiber Materials》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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Cortico-striatal gamma oscillations are modulated by dopamine D3 receptors in dyskinetic rats
《Neural Regeneration Research》2025年第4期1164-1177,共14页Pengfei Wang Yuewei Bi Min Li Jiazhi Chen Zhuyong Wang Huantao Wen Ming Zhou Minjie Luo Wangming Zhang 
supported by the National Natural Science Foundation of China,No.82071254(to WZ).
Long-term levodopa administration can lead to the development of levodopa-induced dyskinesia.Gamma oscillations are a widely recognized hallmark of abnormal neural electrical activity in levodopa-induced dyskinesia.Cu...
关键词：aperiodic components dopamine D3 receptor dorsolateral striatum functional connectivity gamma oscillations levodopa-induced-dyskinesia local field potentials NEUROMODULATION Parkinson’s disease primary motor cortex 
Liquid Subcutaneous Levodopa-Carbidopa ND0612 Effects on Motor Symptoms in Individuals with Parkinson’s Disease: A Systematic Review and Meta-Analysis
《Advances in Parkinson's Disease》2024年第2期9-25,共17页Paula Abola Mitchell Wolden Kristin Lefebvre 
Objective: In the manuscript titled “Liquid subcutaneous Levodopa-Carbidopa ND0612 effects on motor symptoms in individuals with Parkinson’s Disease: A systematic review and meta-analysis”, the objective was to con...
关键词：Parkinson’s Disease ND0612 Levodopa-Carbidopa Motor Symptoms Motor Complications UPDRS 
Improving treatment for Parkinson’s disease:Harnessing photothermal and phagocytosis-driven delivery of levodopa nanocarriers across the blood-brain barrier
《Asian Journal of Pharmaceutical Sciences》2024年第6期163-179,共17页Kaili Liang Li Yang Jiawei Kang Bo Liu Ding Zhang Liyan Wang Wei Wang Qing Wang 
Parkinson’s disease(PD)poses a significant therapeutic challenge,mainly due to the limited ability of drugs to cross the blood-brain barrier(BBB)without undergoing metabolic transformations.Levodopa,a key component o...
关键词：LEVODOPA Oxidative stress Blood-brain barrier Photothermal effect PHAGOCYTOSIS 
Synchronous Dosing of Levodopa with Quercetin Enhances Therapeutic Efficacy and Mitigates Apoptotic Events in Experimental Parkinsonism
《Journal of Bio-X Research》2024年第3期105-113,共9页Arya Indulekha Sureshkumar Chempakam Biju Latha Akshara Pradeep Renjini Ambika Padmanabhan Rajesh Ramachandran 
Parkinson’s disease(PD)affects millions of people annually across the globe and is primarily managed through dopamine replacement therapy employing levodopa(L-DOPA),which is still the preferred gold standard.Prolonge...
关键词：natural synthetic compounds therapeutic efficacy dopamine replacement therapy LEVODOPA Parkinsons disease synchronous dosing QUERCETIN parkinson s disease pd affects 
Finger-actuated wireless-charging wearable multifunctional sweatsensing system for levodopa and vitamin C
《Nano Research》2024年第4期3096-3106,共11页Qihong Ning Shaoqing Feng Qingwen Sun Ruoyao Yu Tangan Li Hao Xu Daxiang Cui Kan Wang 
supported by the National Natural Science Foundation of China(No.32171373);the Projects of International Cooperation and Exchanges NSFC(No.82020108017);the Natural Science Foundation of Shanghai(No.23ZR1414500);the Medical Engineering Cross Project of SJTU(No.YG2021QN141).
Efficient portable wearable sweat sensors allow the long-term monitoring of changes in the status of biomarkers in sweat,which can be useful in diagnosis,medication,and nutritional assessment.In this study,we designed...
关键词：self-pumping microfluidic channel wireless charging wearable sensor health monitoring 
The Dynamics of Dopamine D_(2) Receptor-Expressing Striatal Neurons and the Downstream Circuit Underlying L-Dopa-Induced Dyskinesia in Rats
《Neuroscience Bulletin》2023年第9期1411-1425,共15页Kuncheng Liu Miaomiao Song Shasha Gao Lu Yao Li Zhang Jie Feng Ling Wang Rui Gao Yong Wang 
This work was supported by the National Natural Science Foundation of China(81671109,82071526,and 82071433);the Natural Science Foundation of Shaanxi Province(2021JQ-417).
L-dopa(l-3,4-dihydroxyphenylalanine)-induced dyskinesia(LID)is a debilitating complication of dopamine replacement therapy for Parkinson’s disease.The potential contribution of striatal D_(2) receptor(D2R)-positive n...
关键词：LEVODOPA DYSKINESIA Parkinson's disease D_(2) RECEPTOR Fiber photometry OPTOGENETICS 
Effect of combined scalp and body acupuncture on Parkinson’s disease:A randomized clinical trial被引量：6
《World Journal of Acupuncture-Moxibustion》2022年第4期342-350,共9页Yuan-bin JIA Xiao-jun WANG Xing-ping LIU Peng WANG Chao DENG Zhong-zheng LI Ye ZHAO 
Supported by Funding Scientific Project of Education Division,Henan Province21C0374;Inheritance Studio of"Hunan Provincial Academic School of Five-Meridian Combined with Acupuncture and Tuina",State Administration of Traditional Chinese MedicineLP0118041。
Objective:To observe the therapeutic effect of combined scalp and body acupuncture on the motor symptoms in Parkinson’s disease(PD),and on the score of levodopa equivalent dose(LED).Methods:This is a randomized,singl...
关键词：Parkinson’s disease Motor symptoms Scalp acupuncture Body acupuncture Randomized controlled trial(RCT) Levodopa equivalent dose 
Why do‘OFF’periods still occur during continuous drug delivery in Parkinson’s disease?
《Translational Neurodegeneration》2022年第1期280-293,共14页Silvia Rota Daniele Urso Daniel J.van Wamelen Valentina Leta Iro Boura Per Odin Alberto J.Espay Peter Jenner K.Ray Chaudhuri 
Continuous drug delivery(CDD)is used in moderately advanced and late-stage Parkinson’s disease(PD)to control motor and non-motor fluctuations(‘OFF’periods).Transdermal rotigotine is indicated for early fluctuations...
关键词：‘OFF’periods Continuous drug delivery Continuous dopaminergic stimulation Rotigotine patch Subcutaneous apomorphine infusion Levodopa-carbidopa intestinal gel 
Potential protective role of ACE-inhibitors and AT1 receptor blockers against levodopa-induced dyskinesias:a retrospective case-control study被引量：2
《Neural Regeneration Research》2021年第12期2475-2478,共4页Elena Contaldi Luca Magistrelli Anna VMilner Marco Cosentino Franca Marino Cristoforo Comi 
Growing evidence has highlighted that angiotensin-converting enzyme(ACE)-inhibitors(ACEi)/AT1 receptor blockers(ARBs)may influence the complex interplay between dopamine and the renin-angiotensin system in the nigrost...
关键词：angiotensin-converting enzyme inhibitors AT1 receptor blockers DYSKINESIAS hypertension LEVODOPA motor complications NEUROINFLAMMATION Parkinson’s disease renin-angiotensin system 
Promising drug targets and associated therapeutic interventions in Parkinson's disease被引量：6
《Neural Regeneration Research》2021年第9期1730-1739,共10页Sachchida Nand Rai Payal Singh Ritu Varshney Vivek K.Chaturvedi Emanuel Vamanu M.P.Singh Brijesh Kumar Singh 
supported by UGC Dr.D.S.Kothari Postdoctoral scheme by awarding the fellowship to SNR(Ref.No-F.4-2/2006(BSR)/BL/19-20/0032)。
Parkinson's disease(PD) is one of the most debilitating brain diseases. Despite the availability of symptomatic treatments, response towards the health of PD patients remains scarce. To fulfil the medical needs of the...
关键词：DOPAMINE EPIGENETICS gene therapies glutamate receptor LEVODOPA molecular chaperones monoamine oxidase B mucuna alpha-synuclein Parkinson's disease STRIATUM substantia nigra 
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