RECEPTOR

作品数：1791被引量：5505H指数：25
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相关作者：白波蒋华良嵇汝运陈凯先朱友成更多>>
相关机构：北京大学苏州大学复旦大学南京医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划广东省自然科学基金国家高技术研究发展计划更多>>
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Microglia overexpressing brain-derived neurotrophic factor promote vascular repair and functional recovery in mice after spinal cord injury
《Neural Regeneration Research》2026年第1期365-376,共12页Fanzhuo Zeng Yuxin Li Xiaoyu Li Xinyang Gu Yue Cao Shuai Cheng He Tian Rongcheng Mei Xifan Mei 
supported by the National Natural Science Foundation of China,Nos.82072165 and 82272256(both to XM);the Key Project of Xiangyang Central Hospital,No.2023YZ03(to RM)。
Spinal cord injury represents a severe form of central nervous system trauma for which effective treatments remain limited.Microglia is the resident immune cells of the central nervous system,play a critical role in s...
关键词：ANGIOGENESIS apoptosis brain-derived neurotrophic factor colony stimulating factor 1 receptor inflammation MICROGLIA motor function spinal cord injury vascular endothelial growth factor 
Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation被引量：1
《Neural Regeneration Research》2025年第8期2325-2336,共12页Yafan Bai Hui Ma Yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li 
supported by the National Natural Science Foundation of China,Nos.82204360(to HM)and 82270411(to GW);National Science and Technology Innovation 2030 Major Program,No.2021ZD0200900(to YL)。
Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary injury.In this study,we evaluated hypidone hydrochloride(YL-0...
关键词：antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury 
Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization
《Genes & Diseases》2025年第3期508-522,共15页Huijun Qiu Jiang Liu Jingyi You Ou Zhou Chang Hao Yi Shu Deyu Ma Wenjing Zou Linghuan Zhang Enmei Liu Zhengxiu Luo Luo Ren Gang Geng Lin Zou Danyi Peng Zhou Fu 
supported by the General Basic Research Project from the Ministry of Education Key Laboratory of Child Development and Disorders(China)(No.GBRP202115);the Chongqing Science and Technology Bureau Major Project(China)(No.cstc2020jcyj-msxmX0782).
Pulmonary fibrosis is a devastating lung disease without effective treatment options. Sphingosine-1-phosphate receptor 3 (S1pr3), a receptor for the lipid signaling moleculesphingosine-1-phosphate, has been shown to m...
关键词：BLEOMYCIN IL-4 M2 polarization MACROPHAGE Pulmonary fibrosis S1pr3 
Gamma-aminobutiric acid-B receptor antibody-related limbic encephalitis due to small cell lung carcinoma:Two case reports
《World Journal of Clinical Cases》2025年第16期38-45,共8页Athena D Myrou Martha G Spilioti Anthoula C Tsolaki Antonis N Frontistis Christos G Savopoulos 
BACKGROUND Paraneoplastic limbic encephalitis(LE)is an inflammatory condition that affects the limbic system,cerebellum,and peripheral nervous system.It causes a range of symptoms including short-term memory loss,impa...
关键词：Gamma aminobutyric acid-B receptor antibody Paraneoplastic encephalitis Small cell lung carcinoma Epileptic seizures Limbic encephalitis Case report 
Shikonin is a novel antagonist of prostaglandin E2 receptor 4 that targets myeloid-derived suppressor cells
《Genes & Diseases》2025年第3期80-83,共4页Yang Wang Naijipu Abuduaini Wenjuan Liu Yuanjun Song Zunping Ke Xilong Wang Wei Jiao Si Chen Xianhua Lin Weiwei Yu Weiqiang Lu Bo Feng Jiacheng He 
supported by the Shanghai Key Medical Specialty Program(China)(No.ZK2019A03 to Y.W.);Natural Science Research Funds of Minhang District,Shanghai,China(No.2021MHZ071 to Y.W.);Scientific Research Project funded by Shanghai Fifth People’s Hospital,Fudan University(No.2020WYZT02 to Y.W.);the National Natural Science Foundation of China(No.82373237 to B.F.,82172644 to W.Q.L);ECNU Multifunctional Platform for Innovation(011);The Instruments Sharing Platform of School of Life Science,East China Normal University.
Myeloid-derived suppressor cells(MDSCs)constitute a crucial component of the immunosuppressive tumor microenvironment.1 Prostaglandin E2 receptor 4(EP4)is involved in regulating immunosuppressive MDSC differentiation ...
关键词：myeloid derived suppressor cells prostaglandin e receptor MDSCS cancer immunotherapy EP prostaglandin e receptor ep g protein SHIKONIN 
Neurophysiological mechanisms of electroacupuncture in regulating pancreatic function and adipose tissue expansion
《World Journal of Diabetes》2025年第5期254-270,共17页Yun Liu Zhi Yu Xuan Wang Ming-Qian Yuan Meng-Jiang Lu Mei-Rong Gong Qian Li You-Bing Xia Guan-Hu Yang Bin Xu Gerhard Litscher Tian-Cheng Xu 
Supported by National Natural Science Foundation of China,No.82305376,No.82374577,No.82305375,No.82074532,and No.82405567;The Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD).
BACKGROUND Electroacupuncture(EA)has been recognized for its beneficial effects on glucolipid metabolism,potentially through the regulation of sensory nerve coordination.The expandability of peripancreatic adipose tis...
关键词：Insulin resistance ELECTROACUPUNCTURE Sensory nerve Transient receptor potential vanilloid 1 receptor Pancreatic beta cell Peripancreatic adipose tissue 
Effect of beinaglutide,a thrice-daily GLP-1 receptor agonist,on body weight and metabolic parameters:A systematic review and metaanalysis
《World Journal of Diabetes》2025年第5期374-387,共14页Abul Bashar Mohammad Kamrul-Hasan Vanishri Ganakumar Lakshmi Nagendra Deep Dutta M Rafiqul Islam Joseph M Pappachan 
BACKGROUND Beinaglutide,a short-acting glucagon-like polypeptide-1 receptor agonist,has shown variable efficacy in weight reduction and metabolic control in randomized controlled trials(RCTs).AIM To summarize the ther...
关键词：Beinaglutide Glucagon-like polypeptide-1 receptor agonist OBESITY Type 2 diabetes Weight reduction Metaanalysis 
Molecular basis for shifted receptor recognition by an encephalitic arbovirus
《四川生理科学杂志》2025年第4期722-722,共1页Xiaoyi Fan 
Western equine encephalitis virus(WEEV)is an arbovirus that historically caused large outbreaks of encephalitis throughout the Americas.WEEV binds protocadherin 10(PCDH10)as a receptor,and highly virulent ancestral WE...
关键词：Cryoelectron microscopy Ldlr related proteins Western equine encephalitis virus Receptor recognition ARBOVIRUS mammalian receptors 
Impact of hormone receptor and HER2 conversions on survival after neoadjuvant chemotherapy in breast cancer patients
《Oncology and Translational Medicine》2025年第2期73-80,共8页Ran Feng Lihui Pan Yarong Yao Jinnan Gao Xiaojun Zhang 
supported by grants from the Basic Research Project of Shanxi Science and Technology Department(no.202303021221190);the Shanxi General Surgery“136”Healthcare Engineering Project(no.2024XYZ03)。
Background:This study assessed the frequency of changes in some key receptor status of tumors after neoadjuvant chemotherapy(NAC)in patients with invasive breast cancer and the prognostic impact of these changes.Metho...
关键词：Neoadjuvant chemotherapy Breast cancer Receptor conversions DISCORDANCE Prognostic impact 
Dysregulation of bile acid signal transduction causes neurological dysfunction in cirrhosis rats
《World Journal of Hepatology》2025年第3期140-151,共12页Chao Ren Li Cha Shu-Yue Huang Guo-Hui Bai Jin-Hui Li Xin Xiong Yu-Xing Feng Dui-Ping Feng Long Gao Jin-Yu Li 
Supported by the National Natural Science Foundation of China,No.82200650;the Key Research and Development Projects of Shanxi Province,No.202102130501014;the Natural Science Foundation of Shanxi Province,No.202203021211021,No.202203021212046,and No.20210302123258.
BACKGROUND The pathogenesis of hepatic encephalopathy(HE)remains unclear,and the classical theory of ammonia toxicity lacks sufficient justification.AIM To investigate the potential of bile acids as intervention targe...
关键词：Hepatic encephalopathy Total bile acid THIOACETAMIDE G protein-coupled bile acid receptor 1 Liver cirrhosis 
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