Shikonin is a novel antagonist of prostaglandin E2 receptor 4 that targets myeloid-derived suppressor cells  

作　　者：Yang Wang Naijipu Abuduaini Wenjuan Liu Yuanjun Song Zunping Ke Xilong Wang Wei Jiao Si Chen Xianhua Lin Weiwei Yu Weiqiang Lu Bo Feng Jiacheng He 

机构地区：[1]Department of Urology,The Fifth People’s Hospital of Shanghai,Fudan University,Shanghai 200240,China [2]Department of General Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200020,China [3]Shanghai Key Laboratory of Regulatory Biology,Institute of Biomedical Sciences and School of Life Sciences,East China Normal University,Shanghai 200241,China [4]Shanghai Municipal Health Commission,Shanghai 200125,China [5]Department of Gerontology,The Fifth People’s Hospital of Shanghai,Fudan University,Shanghai 200240,China [6]Joint Center for Translational Medicine,Shanghai Fifth People’s Hospital,Fudan University and School of Life Science,East China Normal University,Shanghai 200240,China

出　　处：《Genes & Diseases》2025年第3期80-83,共4页基因与疾病(英文)

基　　金：supported by the Shanghai Key Medical Specialty Program(China)(No.ZK2019A03 to Y.W.);Natural Science Research Funds of Minhang District,Shanghai,China(No.2021MHZ071 to Y.W.);Scientific Research Project funded by Shanghai Fifth People’s Hospital,Fudan University(No.2020WYZT02 to Y.W.);the National Natural Science Foundation of China(No.82373237 to B.F.,82172644 to W.Q.L);ECNU Multifunctional Platform for Innovation(011);The Instruments Sharing Platform of School of Life Science,East China Normal University.

摘　　要：Myeloid-derived suppressor cells(MDSCs)constitute a crucial component of the immunosuppressive tumor microenvironment.1 Prostaglandin E2 receptor 4(EP4)is involved in regulating immunosuppressive MDSC differentiation and is emerging as a promising target for cancer immunotherapy.2 No EP4 antagonists have been approved for anti-tumor therapy,underscoring the urgent requirement for the discovery of novel EP4 antagonists.G protein and b-arrestin represent two classical downstream pathways for EP4.The inactivity of G protein and b-arrestin serves as a readout to indicate EP4 antagonism,providing a rationale for establishing EP4 drug screening platforms.

关 键 词：myeloid derived suppressor cells prostaglandin e receptor MDSCS cancer immunotherapy EP prostaglandin e receptor ep g protein SHIKONIN 

分 类 号：R730.5[医药卫生—肿瘤]