SHIKONIN

作品数：40被引量：150H指数：7
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Shikonin is a novel antagonist of prostaglandin E2 receptor 4 that targets myeloid-derived suppressor cells
《Genes & Diseases》2025年第3期80-83,共4页Yang Wang Naijipu Abuduaini Wenjuan Liu Yuanjun Song Zunping Ke Xilong Wang Wei Jiao Si Chen Xianhua Lin Weiwei Yu Weiqiang Lu Bo Feng Jiacheng He 
supported by the Shanghai Key Medical Specialty Program(China)(No.ZK2019A03 to Y.W.);Natural Science Research Funds of Minhang District,Shanghai,China(No.2021MHZ071 to Y.W.);Scientific Research Project funded by Shanghai Fifth People’s Hospital,Fudan University(No.2020WYZT02 to Y.W.);the National Natural Science Foundation of China(No.82373237 to B.F.,82172644 to W.Q.L);ECNU Multifunctional Platform for Innovation(011);The Instruments Sharing Platform of School of Life Science,East China Normal University.
Myeloid-derived suppressor cells(MDSCs)constitute a crucial component of the immunosuppressive tumor microenvironment.1 Prostaglandin E2 receptor 4(EP4)is involved in regulating immunosuppressive MDSC differentiation ...
关键词：myeloid derived suppressor cells prostaglandin e receptor MDSCS cancer immunotherapy EP prostaglandin e receptor ep g protein SHIKONIN 
Shikonin protects mitochondria through the NFAT5/AMPK pathway for the treatment of diabetic wounds
《World Journal of Diabetes》2024年第12期2338-2352,共15页Lu-Sha Cen Yi Cao Yi-Mai Zhou Jing Guo Jing-Wen Xue 
Supported by National Natural Science Foundation of China,No.82104862;Zhejiang Provincial Natural Science Foundation of China,No.LTY22E030003;Scientific Research Project Foundation of Zhejiang Chinese Medical University,No.2023FSYYZZ01.
BACKGROUND Shikonin is a natural remedy that is effective at treating diabetic wounds.NFAT5 is a potential therapeutic target for diabetes,and mitochondrial function is essen-tial for wound healing.However,the relatio...
关键词：SHIKONIN Diabetic wounds NFAT5 Mitochondrial function AMPK Wound healing 
紫草素(shikonin)抗奥密克戎毒株的实验研究及机制分析
《中华中医药学刊》2024年第9期23-25,I0001,共4页王秀民 谢小华 孙永 袁媛 崔志梅 张涛 苏彦雷 孙殿兴 吴红海 张晶 
国家自然科学基金项目(81672041);河北省卫生健康委员会重点科研攻关计划项目(20231303);河北省中医药管理局科研计划基金项目(2022455)。
目的探讨右旋体紫草素(shikonin)抗奥密克戎毒株的药理作用和对新型冠状病毒主蛋白酶的抑制活性。方法使用奥密克戎毒株BA.2.2转染的Vero细胞模型检测shikonin的抗病毒活性;利用体外主蛋白酶荧光偏振模型测试shikonin对于新型冠状病毒...
关键词：紫草素 奥密克戎毒株 RNA聚合酶 主蛋白酶 荧光偏振筛选模型 分子对接 
Mycobacterium smegmatis enhances shikonin-induced immunogenic cell death—an efficient in situ tumor vaccine strategy被引量：1
《Journal of Biomedical Research》2024年第4期369-381,共13页Zhaoye Qian Zhe Zhang Lanqi Cen Yaohua Ke Jie Shao Manman Tian Baorui Liu 
supported by grants from the Natural Science Foundation of Huai'an Science and Technology Bureau(Grant No.HAB202312);the Science and Technology Development Fund of the Affiliated Hospital of Xuzhou Medical University(Grant No.XYFY2021018).
Tumor vaccines are a promising avenue in cancer immunotherapy.Despite the progress in targeting specific immune epitopes,tumor cells lacking these epitopes can evade the treatment.Here,we aimed to construct an efficie...
关键词：MYCOBACTERIUM SMEGMATIS SHIKONIN IMMUNOGENIC cell death tumor vaccines IMMUNOGENICITY CYTOTOXICITY 
Effective assignment of positional isomers in dimeric shikonin and its analogs by ^(1)H NMR spectroscopy
《Chinese Chemical Letters》2024年第5期223-226,共4页Ling-Hao Zhao Hai-Wei Yan Jian-Shuang Jiang Xu Zhang Xiang Yuan Ya-Nan Yang Pei-Cheng Zhang 
funded by the CAMS Innovation Fund for Medical Sciences(CIFMS,No.2021-I2M-1-028).
An approach for distinguishing two types of positional isomers of dimeric shikonin and its analogs was explored with ^(4)JC,H long-range correlation by prolonging the acquisition time at ^(2,3)JC,H values of 2.0 and 8...
关键词：Arnebia euchroma Dimeric hydroxyl naphthoquinones Positional isomers ^(1)H NMR spectroscopy Chemical shift difference 
Shikonin from Chinese herbal medicine induces GSDME-controlled pyroptosis in tumor cells
《Journal of Traditional Chinese Medical Sciences》2022年第4期432-442,共11页Dongxiao Cui Sanjiao Wang Jiajian Guo Mingrui Yang Yunqian Li Yue Zhang Wenfu Ma 
This research was supported by the Program for the Research Startup Fund Program at the Beijing University of Chinese Medicine(90011451310011);the Key Research Fund for Drug Discovery in Chinese Medicine at the Beijing University of Chinese Medicine(1000061223740);the Experimental Technology Standardization Research Project at the Beijing University of Chinese Medicine(2021-SYJS-009);the Fundamental Research Funds for the Central Universities of the Beijing University of Chinese Medicine(2020-JYB-ZDGG-057).
Objective:To investigate the potential anti-tumor mechanisms of naphthoquinone compound shikonin(SKN)extracted from the root of Chinese herbal medicine plant lithospermum(Lithospermum erythrorhizon Sieb.&Zucc.).Method...
关键词：SHIKONIN Naphthoquinone compounds PYROPTOSIS Gasdermin Anti-tumor activity HeLa cells 
Shikonin alleviates collagen-induced arthritis mice by inhibiting M1 macrophage polarization被引量：2
《Journal of Traditional Chinese Medicine》2022年第6期932-939,共8页HE Lianhua LUAN Huijie QIN Qingxia HE Juan CHEN Jian HU Yiping CAI Yueming SUN Desheng SHI Yu WANG Qingwen 
Supported by Traditional Chinese Medicine Bureau of Guangdong Province:the Role and Mechanism of Ermiao San in the Regulation of Th cell Differentiation by PKC-? in the Treatment of RA (No. 20211333);National Natural Science Foundation of China:the Role and Mechanism of CD4+T Cell Smad7 Loss in the Pathogenesis of Rheumatoid Arthritis(No. 81974253);the Significance of Regulating Glycolytic Metabolism by HK-2 in Dendritic Cell Migration and RA Pathogenesis (No. 81901641);Shenzhen Science and Technology Innovation Committee:Research on Key Technologies of Intelligent Robot Based on Artificial Intelligence Image Data (No. GJHZ20200731095208025);Municipal Development and Reform Commission:Virtual Reality Clinical Application Public Service Platform (XMHT20190104001);Project of Shenzhen Municipal Health Commission:Biological Markers in Idiopathic Inflammatory Myopathy and Clinical Significance of Tumorigenesis (No. SZXJ2017046);Nature Science Foundation of Guangdong Province:Experimental Study on Treatment of Rabbit Rheumatoid Arthritis with Lipidated Methotrexate Microbubbles Combined with Controlled Release by Ultrasonic Irradiation (No. 2018A030313281)。
OBJECTIVE: To investigate the effects of shikonin(SKN) on M1 and M2 polarization of macrophages both in vitro and in vivo. METHODS: Collagen-induced arthritis(CIA) in male DBA/1 mice were treated with a dose of 4 mg/k...
关键词：SHIKONIN ARTHRITIS RHEUMATOID MACROPHAGES M1 polarization 
Pharmacological and analytical aspects of alkannin/shikonin and their derivatives:An update from 2008 to 2022被引量：4
《Chinese Herbal Medicines》2022年第4期511-527,共17页Kirandeep Kaur Rashi Sharma Atamjit Singh Shivani Attri Saroj Arora Sarabjit Kaur Neena Bedi 
Alkannin/shikonin(A/S)and their derivatives are naturally occurring naphthoquinones majorly found in Boraginaceae family plants.They are integral constituents of traditional Chinese medicine Zicao(roots of Lithospermu...
关键词：ALKANNIN NAPHTHOQUINONES patents SHIKONIN 
Research Progress on Pharmacological Effects of Shikonin Compound β-acetoxyisovalerylalkannin
《Medicinal Plant》2022年第2期1-3,7,共4页Anqi WANG Chenghao JIN 
Central Support for Local University Reform and Development Fund Talent Training Project(2020GSP16);College Student Innovation and Entrepreneurship Project(202110223004).
Shikonin compoundβ-acetoxyisovalerylalkannin is a kind of high fat-soluble naphthoquinone pigment,which can exert its pharmacological effects including anticancer,anti-inflammatory,bacteriostatic and antiviral effect...
关键词：β-acetoxyisovalerylalkannin ANTICANCER ANTI-INFLAMMATION BACTERIOSTASIS ANTI-VIRUS 
Chemical screen identifies shikonin as a broad DNA damage response inhibitor that enhances chemotherapy through inhibiting ATM and ATR被引量：1
《Acta Pharmaceutica Sinica B》2022年第3期1339-1350,共12页Fangfang Wang Sora Jin Franklin Mayca Pozo Danmei Tian Xiyang Tang Yi Dai Xinsheng Yao Jinshan Tang Youwei Zhang 
supported by Guangdong Basic and Applied Basic Research Foundation(2021A1515011244,China)to Jinshan Tang;the National 111 Project of China(No.B13038,China)to Xinsheng Yao。
DNA damage response(DDR)is a highly conserved genome surveillance mechanism that preserves cell viability in the presence of chemotherapeutic drugs.Hence,small molecules that inhibit DDR are expected to enhance the an...
关键词：Chemical screen SHIKONIN DNA damage Response ATM ATR ATRIP Protein degradation Chemo sensitizing 
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