ALKANNIN

作品数：6被引量：15H指数：2
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相关领域：医药卫生生物学更多>>
相关作者：邸旭曲鑫更多>>
相关机构：天津市第四中心医院更多>>
相关期刊：《Chemical Research in Chinese Universities》《Chinese Herbal Medicines》《Regenerative Biomaterials》《医学理论与实践》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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PKM2抑制剂Alkannin对乳腺癌恶性进展的影响及机制研究
《医学理论与实践》2024年第12期1994-1997,共4页曲鑫 邸旭 
天津市卫生健康委员会科技项目(ZC20098)。
目的:M2型丙酮酸激酶(PKM2)在多种肿瘤中异常表达并有望成为潜在治疗靶点,本研究旨在阐明PKM2特异性小分子抑制剂Alkannin对乳腺癌恶性进展的影响及其分子机制。方法:通过生物信息学分析鉴定PKM2在乳腺癌组织及癌旁正常组织中的表达情...
关键词：乳腺癌 ALKANNIN M2型丙酮酸激酶 Β-连环蛋白 
Pharmacological and analytical aspects of alkannin/shikonin and their derivatives:An update from 2008 to 2022被引量：4
《Chinese Herbal Medicines》2022年第4期511-527,共17页Kirandeep Kaur Rashi Sharma Atamjit Singh Shivani Attri Saroj Arora Sarabjit Kaur Neena Bedi 
Alkannin/shikonin(A/S)and their derivatives are naturally occurring naphthoquinones majorly found in Boraginaceae family plants.They are integral constituents of traditional Chinese medicine Zicao(roots of Lithospermu...
关键词：ALKANNIN NAPHTHOQUINONES patents SHIKONIN 
Novel electrospun poly-hydroxybutyrate scaffolds as carriers for the wound healing agents alkannins and shikonins被引量：2
《Regenerative Biomaterials》2021年第3期94-109,共16页Athanasios S.Arampatzis Konstantina Giannakoula Konstantinos N.Kontogiannopoulos Konstantinos Theodoridis Eleni Aggelidou Angelique Rat Elli Kampasakali Anne Willems Dimitrios Christofilos Aristeidis Kritis Vassilios P.Papageorgiou Ioannis Tsivintzelis Andreana N.Assimopoulou 
This work was supported by the project‘MICROMETABOLITE’that has received funding from the European Union’s Horizon 2020 research and innovation programme,under the Marie Skłodowska-Curie grant agreement[No 721635];A.S.Arampatzis,K.N.Kontogiannopoulos,A.Rat,A.Willems and A.N.Assimopoulou acknowledge support of this work from MICROMETABOLITE.
The aim of this study was to investigate the potential of novel electrospun fiber mats loaded with alkannin and shikonin(A/S)derivatives,using as carrier a highly biocompatible,bio-derived,ecofriendly polymer such as ...
关键词：electrospinning POLYHYDROXYALKANOATES ALKANNIN SHIKONIN wound healing 
Design and synthesis of biotinylated dimethylation of alkannin oxime derivatives被引量：2
《Chinese Chemical Letters》2017年第2期453-457,共5页Guang Huang Qing-Qing Meng Wen Zhou Qi-Jing Zhang Jin-Yun Dong Shao-Shun Li 
supported by National Natural Science Foundation of China (No. 81373274);Ph.D. Programs Foundation of Ministry of Education China (No. 20120073110068);Shanghai Biomedical Supporting Funding (No. 15431900600)
DMAKO-05,a novel dimethylation of alkannin oxime derivative,exhibits remarkable anticancer activity as well as excellent cellular selectivity and thus has been considered as a promising antineoplastic agent for colore...
关键词：Alkannin and shikonin oxime derivatives Anticancer activity Biotin probe Molecular target Mitsunobu reaction 
Design, Synthesis and Anticancer Activity of Shikonin and Alkannin Derivatives with Different Substituents on the Naphthazarin Scaffold被引量：7
《Chemical Research in Chinese Universities》2015年第3期394-400,共7页ZHANG Xu CUI Jiahua ZHOU Wen LI Shaoshun 
the National Natural Science Foundation of China（No.81373274） and the State Key Laboratory Cultivatlon Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China （No.CHEMR2012-B08）.
Based on the asymmetric reduction of alkannin ketone derivative 4 by diisopinocampheylchloro- borane（DIP-C1）, a series of shikonin and alkannin derivatives was designed, synthesized and their anticancer activi- ties...
关键词：Shikonin and alkannin oxime derivative Asymmetric reduction ANTICANCER Apoptosis Cell cycle 
New Asymmetric Synthesis of Alkannin and Shikonin被引量：2
《Chinese Chemical Letters》2005年第4期465-467,共3页JianGangZHANC QunLU WenHuDUAN JunCaoCAI 
the National Natural Science Foundation of China[32071532]for financial supports
A new approach for asymmetric synthesis of alkannin and shikonin is presented. The chiral centers of the targets were introduced via an asymmetric C-arylation of protected chiral glyceraldehyde in high de. The two e...
关键词：Asymmetric synthesis ALKANNIN SHIKONIN arylglycerols. 
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