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作 者:Athanasios S.Arampatzis Konstantina Giannakoula Konstantinos N.Kontogiannopoulos Konstantinos Theodoridis Eleni Aggelidou Angelique Rat Elli Kampasakali Anne Willems Dimitrios Christofilos Aristeidis Kritis Vassilios P.Papageorgiou Ioannis Tsivintzelis Andreana N.Assimopoulou
机构地区:[1]Laboratory of Organic Chemistry,School of Chemical Engineering,Aristotle University of Thessaloniki(AUTh),Thessaloniki 54124,Greece [2]Natural Products Research Centre of Excellence(NatPro-AUTh),Center of Interdisciplinary Research and Innovation of Aristotle University of Thessaloniki(CIRI-AUTh),Thessaloniki 57001,Greece [3]Department of Physiology and Pharmacology,School of Medicine,Faculty of Health Sciences,Aristotle University of Thessaloniki(AUTh),Thessaloniki,Greece [4]Laboratory of Microbiology,Faculty of Sciences,Ghent University,Ghent 9000,Belgium [5]Faculty of Engineering,School of Chemical Engineering and Physics Laboratory,Aristotle University of Thessaloniki,Thessaloniki 54124,Greece [6]Physical Chemistry Laboratory,School of Chemical Engineering,Aristotle University of Thessaloniki,Thessaloniki 54124,Greece
出 处:《Regenerative Biomaterials》2021年第3期94-109,共16页再生生物材料(英文版)
基 金:This work was supported by the project‘MICROMETABOLITE’that has received funding from the European Union’s Horizon 2020 research and innovation programme,under the Marie Skłodowska-Curie grant agreement[No 721635];A.S.Arampatzis,K.N.Kontogiannopoulos,A.Rat,A.Willems and A.N.Assimopoulou acknowledge support of this work from MICROMETABOLITE.
摘 要:The aim of this study was to investigate the potential of novel electrospun fiber mats loaded with alkannin and shikonin(A/S)derivatives,using as carrier a highly biocompatible,bio-derived,ecofriendly polymer such as poly[(R)-3-hydroxybutyric acid](PHB).PHB fibers containing a mixture of A/S derivatives at different ratios were successfully fabricated via electrospinning.As evidenced by scanning electron microscopy,the fibers formed a bead-free mesh with average diameters from 1.25 to 1.47 lm.Spectroscopic measurements suggest that electrospinning marginally increases the amorphous content of the predominantly crystalline PHB in the fibers,while a significant drug amount lies near the fiber surface for samples of high total A/S content.All scaffolds displayed satisfactory characteristics,with the lower concentrations of A/S mixture-loaded PHB fiber mats achieving higher porosity,water uptake ratios,and entrapment efficiencies.The in vitro dissolution studies revealed that all samples released more than 70%of the encapsulated drug after 72 h.All PHB scaffolds tested by cell viability assay were proven non-toxic for Hs27 fibroblasts,with the 0.15 wt.%sample favoring cell attachment,spreading onto the scaffold surface,as well as cell proliferation.Finally,the antimicrobial activity of PHB meshes loaded with A/S mixture was documented for Staphylococcus epidermidis and S.aureus.
关 键 词:electrospinning POLYHYDROXYALKANOATES ALKANNIN SHIKONIN wound healing
分 类 号:R318[医药卫生—生物医学工程]
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