Gamma-aminobutiric acid-B receptor antibody-related limbic encephalitis due to small cell lung carcinoma:Two case reports  

作　　者：Athena D Myrou Martha G Spilioti Anthoula C Tsolaki Antonis N Frontistis Christos G Savopoulos 

机构地区：[1]Department of Internal Medicine,AHEPA University General Hospital,Thessaloniki 54636,Greece [2]Department of Neurology,AHEPA University General Hospital,Thessaloniki 54636,Greece [3]Department of Internal Medicine,Aristotle University of Thessaloniki,AHEPA University General Hospital,Thessaloniki 54636,Greece

出　　处：《World Journal of Clinical Cases》2025年第16期38-45,共8页世界临床病例杂志(英文)

摘　　要：BACKGROUND Paraneoplastic limbic encephalitis(LE)is an inflammatory condition that affects the limbic system,cerebellum,and peripheral nervous system.It causes a range of symptoms including short-term memory loss,impaired cognitive function,behavioral and psychological disorders,and seizures.Paraneoplastic LE can occur when an immune response is activated due to antibodies targeting gammaaminobutyric acid(GABA)B receptor(GABABR)interacting with antigens on tumor cells and the nervous system,resulting in tumors primarily as small cell lung carcinoma(SCLC).CASE SUMMARY We discuss two cases of GABABR antibody-related LE resulting from SCLC.The patients’symptoms were managed with immunotherapy but ended in premature death due to chemotherapy-related complications.CONCLUSION Paraneoplastic syndrome is a notable cause of LE.Early intravenous immunoglobulin therapy may lead to temporary remission.

关 键 词：Gamma aminobutyric acid-B receptor antibody Paraneoplastic encephalitis Small cell lung carcinoma Epileptic seizures Limbic encephalitis Case report 

分 类 号：R73[医药卫生—肿瘤]