BLEOMYCIN

作品数：95被引量：269H指数：8
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相关机构：河北医科大学上海市肺科医院北京大学中山医科大学更多>>
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Inhibition of sphingosine 1-phosphate receptor 3 ameliorates bleomycin-induced pulmonary fibrosis by suppressing macrophage M2 polarization
《Genes & Diseases》2025年第3期508-522,共15页Huijun Qiu Jiang Liu Jingyi You Ou Zhou Chang Hao Yi Shu Deyu Ma Wenjing Zou Linghuan Zhang Enmei Liu Zhengxiu Luo Luo Ren Gang Geng Lin Zou Danyi Peng Zhou Fu 
supported by the General Basic Research Project from the Ministry of Education Key Laboratory of Child Development and Disorders(China)(No.GBRP202115);the Chongqing Science and Technology Bureau Major Project(China)(No.cstc2020jcyj-msxmX0782).
Pulmonary fibrosis is a devastating lung disease without effective treatment options. Sphingosine-1-phosphate receptor 3 (S1pr3), a receptor for the lipid signaling moleculesphingosine-1-phosphate, has been shown to m...
关键词：BLEOMYCIN IL-4 M2 polarization MACROPHAGE Pulmonary fibrosis S1pr3 
Sex differences in CXCL4-mediated lung damage in the bleomycin-induced systemic sclerosis mice model
《Rheumatology & Autoimmunity》2024年第4期235-241,共7页Yi'an Tian Jingyan Li Bingrui Yu Yu Chen Tianping Bao Yuhong Li 
Nanjing Medical University Science and Technology Development Fund,Grant/Award Number:NMUB20220211;Huai'an Natural Science Research Program,Grant/Award Number:HAP202308。
Background:Sex is an independent risk factor for systemic sclerosis(SSc).Chemokine ligand 4(CXCL4)participates in SSc via multiple mechanisms.In the present study,we investigated the role of CXCL4 in sex-specific lung...
关键词：CXCL4 lung injury SEX systemic sclerosis 
A neonate in emergency for giant auricular and cervical lymphatic malformations:Ultrasound-guided percutaneous bleomycin sclerotherapy may be a choice
《Pediatric Investigation》2024年第4期316-318,共3页Jiaojiao Ding Mingyan Hei Wenjia Cai Wenyuan Shi Xin Ni 
To the editor:Lymphatic malformations(LMs)are benign anomalies often detected at birth,with an incidence of 1.2–2.8 per 1000 newborns.1 While most early-life LMs are asymptomatic and may only require observation,some...
关键词：ultrasound guided percutaneous bleomycin sclerotherapy cervical lymphatic malformations emergency significant cosmetic deformities NEONATE giant auricular 
Spatial transcriptomic analysis deciphers adipocyte-to-fibroblast transformation in bleomycin-induced murine skin fibrosis
《Chinese Medical Journal》2024年第22期2745-2757,共13页Yixiang Zhang Jiahao He Fangzhou Xie Shengzhou Shan Jiaqi Qin Chuandong Wang Qingfeng Li Yun Xie Bin Fang 
supported from grants from the National Natural Science Foundation of China(No.82102327);Clinical Research Program of 9th People’s Hospital,Shanghai JiaoTong University School of Medicine(No.JYLJ202103)。
Background:Scleroderma is characterized by inflammation and fibrosis,predominantly occurring in the skin and extending to various parts of the body.The pathophysiology of scleroderma is multifaceted,with the current u...
关键词：Spatial transcriptome SCLERODERMA ADIPOCYTES Fibroblasts 
Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice
《Asian Pacific Journal of Tropical Biomedicine》2024年第9期391-400,I0008-I0291,共294页Swapnil Gavhane Chandrakant Gawli Sachin Kumar Biswajit Das Gayatri Marathe Vishal S.Patil Harun M.Patel Basavaraj Bommanahalli Chanakya Nath Kundu Chandragouda R.Patil 
Objective:To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis(IPF)and to explore its underlying mechanisms using network pharmacology.Methods:IPF was induced in C57BL/6 mice by a ...
关键词：TRIGONELLINE Idiopathic pulmonary fibrosis ANTIFIBROTIC BLEOMYCIN Network pharmacology 
Effect of growth hormone on colonic anastomosis after intraperitoneal administration of 5-fluorouracil, bleomycin and cisplatin: An experimental study
《World Journal of Gastrointestinal Surgery》2024年第8期2679-2688,共10页Ioannis Lambrou Ioannis Mantzoros Orestis Ioannidis Dimitrios Tatsis Elissavet Anestiadou Vasiliki Bisbinas Manousos-Georgios Pramateftakis Efstathios Kotidis Barbara Driagka Ourania Kerasidou Savvas Symeonidis Stefanos Bitsianis Freideriki Sifaki Konstantinos Angelopoulos Haralabos Demetriades Stamatios Angelopoulos 
BACKGROUND Growth hormone(GH)plays a crucial role in wound healing and tissue repair in postoperative patients.In particular,colonic anastomosis healing following colorectal surgery is impaired by numerous chemotherap...
关键词：Growth hormone Colonic anastomosis Adhesion Bursting pressure COLLAGEN HYDROXYPROLINE Inflammation NEOANGIOGENESIS Chemotherapy 
Inhalation of taraxasterol loaded mixed micelles for the treatment of idiopathic pulmonary fibrosis被引量：1
《Chinese Chemical Letters》2024年第8期475-480,共6页Tong Zhang Chao Sun Shubin Yang Zimin Cai Sifeng Zhu Wendian Liu Yun Luan Cheng Wang 
supported by National Natural Science Foundation of China(No.31872754);Fundamental Research Funds for the Central Universities(No.201964018).
Idiopathic pulmonary fibrosis(IPF)is a chronic and fatal lung disease characterized by pulmonary inflam-mation,oxidative stress,and excessive extracellular matrix(ECM)deposition.Current anti-fibrotic drugs for IPF tre...
关键词：Taraxasterol Idiopathic pulmonary fibrosis Mixed polymeric micelles Pulmonary administration BLEOMYCIN 
Ism1 deficiency in mice exacerbates bleomycin-induced pulmonary fibrosis with enhanced cellular senescence and delayed fibrosis resolution
《hLife》2024年第7期342-359,共18页Mahalakshmi Shanmugasundaram Simin Xu Yujie Yang Jong Huat Tee Terence Yin Weng Lam Ruowen Ge 
supported by the grant awarded to R.G.from the Singapore Ministry of Education(partially supported by grants A-8001134-00-00 and MOE-T2EP30221-0011).
Idiopathic pulmonary fibrosis(IPF)is a progressive fibrosing interstitial lung disease with high morbidity and mortality but unclear etiology and incomplete pathophysiological understandings,making the discovery of ef...
关键词：isthmin-1(ISM1) pulmonary fibrosis ANTI-INFLAMMATION cellular senescence lipofibroblast lipid metabolism 
Investigating the mechanism of action of Bu-Yang-Huan-Wu decoction in treating bleomycin-Induced pulmonary fibrosis through the epithelial-mesenchymal transition pathway
《Toxicology Advances》2024年第1期10-15,共6页Yu-Ming Wang Han-Zhou Li Huan-Tian Cui Yu-Hong Bian 
Background:To explore the effects and mechanisms of Bu-Yang-Huan-Wu Decoction on pulmonary fibrosis in mice.Methods:Forty-five C57BL/6J mice were randomly divided into three groups:Control,Model,and Bu-Yang-Huan-Wu De...
关键词：pulmonary fibrosis Bu-Yang-Huan-Wu decoction epithelial-mesenchymal transition BLEOMYCIN 
Pharmacodynamic study of cannabidiol on bleomycin-induced pulmonary fibrosis in rats
《Journal of Hainan Medical University》2023年第22期1-8,共8页SUN Meng-di ZHANG Fei-yu GAO Xin WANG Yu CHEN Ping-ping LIU Shu-min 
Post-doctoral Program of Heilongjiang Province (No.LBH-Z22251);Chinese Medicine Research Project of Heilongjiang Province (No.ZHY2022-114);Heilongjiang Chinese Medicine Association Youth Talent Promotion Project (No.2022-QNRC1-27)。
Objective:To study the protective effect of cannabidiol(CBD)on rats with pulmonary fibrosis and explore the possible mechanism of the use of CBD in the treatment of pulmonary fibrosis.Methods:Sixty SD rats were random...
关键词：CANNABIDIOL Pulmonary fibrosis INFLAMMATION Oxidative stress PHARMACODYNAMICS 
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