云南高校图书馆联盟文献共享服务平台- ANTIFIBROTIC

ANTIFIBROTIC: 作品数：31被引量：152H指数：8; 导出分析报告; 相关领域：医药卫生生物学更多>>; 相关作者：张俊平顾民韩志坚陶俊王子杰更多>>; 相关机构：第二军医大学江苏省人民医院南京医科大学更多>>; 相关期刊：《Chinese Journal of Integrative Medicine》《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《World Journal of Gastrointestinal Pharmacology and Therapeutics》更多>>; 相关基金：国家自然科学基金福建省自然科学基金上海市浦江人才计划项目上海市自然科学基金更多>>

Hepatic Surf4 Deficiency Impairs Serum Amyloid A1 Secretion and Attenuates Liver Fibrosis in Mice: 《Research》2025年第1期921-934,共14页Bingxiang Wang Huili Li Govind Gill Xiangyan Zhang Geru Tao Boyan Liu Lei Zhai Wei Chen Hao Wang Hong-Mei Gu Shucun Qin Da-Wei Zhang; supported by the National Natural Science Foundation of China(NSFC 81929002);a grant from the Canadian Institutes of Health Research(PS 178091);the Academic promotion program of Shandong First Medical University(2019QL010);the Natural Science Foundation of Shandong Province(ZR2021MH015);D.W.Z.was also supported by the Natural Sciences and Engineering Research Council of Canada(RGPIN-2016-06479);S.Q.was also supported by the Taishan Scholars Foundation of Shandong Province(ts201511057).; Liver fibrosis is a severe global health problem.However,no effective antifibrotic drugs have been approved.Surf4 is primarily located in the endoplasmic reticulum(ER)and mediates the transport of secreted proteins fr...; 关键词：golgi apparatusknockout proteomics collagen antifibrotic drugs serum amyloid liver fibrosis endoplasmic reticulum er

Regression of hepatic fibrosis after pharmacological therapy for nonalcoholic steatohepatitis: 《World Journal of Gastrointestinal Pharmacology and Therapeutics》2024年第6期18-27,共10页Mohamed Abdel-Samiee Essam Salah Ibrahim Mohamed Kohla Eman Abdelsameea Mohsen Salama; The global incidence of nonalcoholic fatty liver disease(NAFLD)is escalating considerably.NAFLD covers a range of liver conditions from simple steatosis to the more severe form known as nonalcoholic steatohepatitis,wh...; 关键词：Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis MYOFIBROBLASTS FIBROSIS Antifibrotic pharmacotherapy Nonalcoholic fatty liver disease treatment strategies Emerging treatments for nonalcoholic steatohepatitis

Timing impact on the initiation of pirfenidone therapy on idiopathic pulmonary fibrosis disease progression: 《World Journal of Clinical Cases》2024年第32期6538-6542,共5页Basma M E Mohamed Mohamed E A Abdelrahim; In this editorial,we comment on the article by Lei et al,with a specific focus on the timing of the initiation of the antifibrotic agent pirfenidone(PFD)in the management of idiopathic pulmonary fibrosis(IPF)and its i...; 关键词：Idiopathic pulmonary fibrosis Pirfenidone Pirfenidone anti-inflammatory mechanism Pirfenidone antifibrotic activity Timing impact

Dual peroxisome proliferator-activated receptorα/δagonists:Hope for the treatment of alcohol-associated liver disease?被引量：1: 《World Journal of Gastroenterology》2024年第37期4163-4167,共5页Xin-Yang Zhang Qin-Jun-Jie Chen Feng Zhu Min Li Dan Shang; Supported by National Natural Science Foundation of China,No.82172754 and No.81874208;Natural Science Foundation Project of Hubei Province,No.2021CFB562.; In this letter,we review the article“Effects of elafibranor on liver fibrosis and gut barrier function in a mouse model of alcohol-associated liver disease”.We focus specifically on the detrimental effects of alcoho...; 关键词：Alcohol-associated liver disease FIBROSIS Antifibrotic effect Elafibranor Peroxisome proliferator-activated receptor

Trigonelline mitigates bleomycin-induced idiopathic pulmonary fibrosis in mice: 《Asian Pacific Journal of Tropical Biomedicine》2024年第9期391-400,I0008-I0291,共294页Swapnil Gavhane Chandrakant Gawli Sachin Kumar Biswajit Das Gayatri Marathe Vishal S.Patil Harun M.Patel Basavaraj Bommanahalli Chanakya Nath Kundu Chandragouda R.Patil; Objective:To evaluate the effect of trigonelline on bleomycin-induced idiopathic pulmonary fibrosis(IPF)and to explore its underlying mechanisms using network pharmacology.Methods:IPF was induced in C57BL/6 mice by a ...; 关键词：TRIGONELLINE Idiopathic pulmonary fibrosis ANTIFIBROTIC BLEOMYCIN Network pharmacology

Asperochones A and B,two antimicrobial aromatic polyketides from the endophytic fungus Aspergillus sp.MMC-2: 《Chinese Chemical Letters》2024年第9期206-209,共4页Hong Zhang Cui-Ping Li Li-Li Wang Zhuo-Da Zhou Wen-Sen Li Ling-Yi Kong Ming-Hua Yang; supported by the National Natural Science Foundation of China(No.32170403);the 111 Center from Ministry of Education of China and the State Administration of Foreign Experts Affairs of China(No.B18056);the“Double First-Class”University Project(No.CPU2018GF03);the Drug Innovation Major Project(Nos.2018ZX09711-001-007 and 2018ZX09735002-003)。; Two novel fungal metabolites,asperochones A and B,were obtained from an Aspergillus sp.Their structures were determined by 1D/2D nuclear magnetic resonance(NMR)spectroscopy,high resolution electrospray ionization mass...; 关键词：Aspergillus sp. Asperochones A and B Aromatic polyketides Heterotrimeric compound Anti-tuberculosis effect Antifibrotic activity

Natural compound fraxinellone ameliorates intestinal fibrosis in mice via direct intervention of HSP47-collagen interaction in the epithelium被引量：1: 《Acta Pharmacologica Sinica》2023年第12期2469-2478,共10页Jie Wang Mei Bai Cui Zhang Ning An Li Wan Xiao-ning Wang Rong-hui Du Yan Shen Zhi-yao Yuan Xu-dong Wu Xue-feng Wu Qiang Xu; the National Natural Science Foundation of China(Nos.82073910,82173871,21937005);the Open Fund of State Key Laboratory of Pharmaceutical Biotechnology,Nanjing University,China(Grant No.KF-GN-202101);Fundamental Research Funds for the Central University(021414380503).; Intestinal fibrosis is a common complication of inflammatory bowel disease.There is still a lack of effective drugs for the prevention or treatment of intestinal fibrosis.Heat shock protein 47(HSP47)plays a key role i...; 关键词：intestinal fibrosis inflammatory bowel disease fraxinellone HSP47 COLLAGEN antifibrotic drugs

Peptidome analysis of human intrauterine adhesion tissues and the identification of antifibrotic peptide被引量：3: 《The Journal of Biomedical Research》2022年第4期280-296,共17页Xiangdong Hua Yan Zhang Juan Xu Lu Xu Yaqian Shi Dazhen Yang Xiaoyan Gu Sumin Wang Xuemei Jia Feng Xu Jie Chen Xiaoyan Ying; supported by the National Natural Science Foundation of China(81701399 to X.H.,81801404 to L.X.and 81702561 to J.C.);Research Innovation Program for Graduates of Jiangsu Province to Y.S.(JX10413759);Maternal and Child Health Research Projects in Jiangsu Province,China to X.Y.(F201513).; Intrauterine adhesion(IUA)is a common clinical endometrial disease,which can severely damage the fertility and quality of life in women.This study aims to find the differentially expressed endogenous peptides and thei...; 关键词：Asherman's syndrome FIBROSIS PEPTIDE stromal cells

N-n-Butyl haloperidol iodide ameliorates liver fibrosis and hepatic stellate cell activation in mice: 《Acta Pharmacologica Sinica》2022年第1期133-145,共13页Dai-fei Shen He Cheng Bo-zhi Cai Wen-feng Cai Bin Wang Qing Zhu Yue-bin Wu Man Liu Run-ji Chen Fen-fei Gao Yan-mei Zhang Yong-dong Niu Gang-gang Shi; This work was supported by the Research Team Project of the Natural Science Foundation of Guangdong Province of China(No.9351503102000001).The authors thank the Pharmacological Department and Shantou University Medical College for providing the platform for our research.; N-n-Butyl haloperidol iodide(F_(2))is a novel compound that has antiproliferative and antifibrogenic activities.In this study we investigated the therapeutic potential of F_(2) against liver fibrosis in mice and the u...; 关键词：liver fibrosis N-n-butyl haloperidol iodide ANTIFIBROTIC C-JUN TGFBR2 TGF-βsignaling human hepatic stellate cell line LX-2

An Update on Efficacy and Safety of Emerging Hepatic Antifibrotic Agents被引量：2: 《Journal of Clinical and Translational Hepatology》2021年第1期60-70,共11页Vinka Rupcic Rubin Kristina Bojanic Martina Smolic Jurica Rubin Ashraf Tabll Robert Smolic; funded by grant from Croatian Ministry of Science and Education dedicated to multi-year institutional funding of scientific activity at the J.J.Strossmayer University of Osijek,Osijek,Croatia—grant number:IP6-MEFOS-2019(to R.S.).; Liver fibrosis represents a response to chronic liver injury.Metabolic dysfunction-associated fatty liver disease and metabolic dysfunction-associated steatohepatitis are the most common chronic liver diseases,both wi...; 关键词：Liver fibrosis MAFLD MASH Clinical trials Antifibrotic agents Efficacy Safety

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

ANTIFIBROTIC

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

ANTIFIBROTIC

检索结果分析

下载全文

用户登录

高级检索检索式检索