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Pharmacological intervention for chronic phase of spinal cord injury: 《Neural Regeneration Research》2025年第5期1377-1389,共13页Chihiro Tohda; Spinal cord injury is an intractable traumatic injury. The most common hurdles faced during spinal cord injury are failure of axonal regrowth and reconnection to target sites. These also tend to be the most challengin...; 关键词：axonal growth chronic phase clinical study PHARMACOTHERAPY spinal cord injury

Screening optimal target populations with symptomatic bradyarrhythmia for pharmacotherapy:a discriminant analysis pilot study: 《Journal of Traditional Chinese Medicine》2025年第1期160-166,共7页ZHANG Wantong YI Danhui LU Fang YANG Qiaoning SHI Shuai LI Qiuyan WENG Weiliang WANG Xujie ZHU Baochen; National Natural Science Foundation of China(No.82004352);National Medicine Master's Inheritance Studio Construction Project of the State Administration of Traditional Chinese Medicine(Weng Weiliang Academic Succession Studio);the Fundamental Research Funds for the Central Public Welfare Research Institutes(ZZ14-YQ-006)。; OBJECTIVE:To screen the target population with symptomatic bradyarrhythmia for pharmacotherapy.METHODS:This study use database from clinical trial that use Yuanjiang decoction(元姜方),a traditional Chinese medicinal p...; 关键词：health services needs and demand BRADYCARDIA discriminant analysis drug therapy medicine Chinese traditional

Integrating machine learning and human use experience to identify personalized pharmacotherapy in Traditional Chinese Medicine:a case study on resistant hypertension: 《Journal of Traditional Chinese Medicine》2025年第1期192-200,共9页CHE Qianzi LIU Dasheng XIANG Xinghua TIAN Yaxin XIE Feibiao XU Wenyuan LIU Jian WANG Xuejie WANG Liying BAI Weiguo HAN Xuejie YANG Wei; the China Academy of Chinese Medical Sciences,Independent Topic Project:Application Research on Named Entity Recognition and Relationship Extraction of Case Records of Renowned Traditional Chinese Medicine Practitioners(No.Z0643).China Academy of Chinese Medical Sciences,Independent Topic Project:Analysis of Research Directions and Scope in the Discipline of Traditional Chinese Medicine Statistics(No.Z0723);China Academy of Chinese Medical Sciences,Science and Technology Innovation Project:Real-world Effectiveness Evaluation of Traditional Chinese Medicine and Translational Application Research on Causal Inference(No.CI2021A04706).China Academy of Chinese Medical Sciences,Science and Technology Innovation Project:Research on Causal Inference Methodology for Real-world Clinical Evaluation in Traditional Chinese Medicine(No.CI2021B003);National Key Research and Development Program of China:Integrated Evaluation Model and Key Technologies of"Syndrome-Disease-Prescription"for Traditional Chinese Medicine in the Prevention and Treatment of Coronary Heart Disease—Statistical Data Analysis and Data Mining(No.2017YFC1700406-2)。; OBJECTIVE:To enhance the understanding of identifying personalized pharmacotherapy options in Traditional Chinese Medicine(TCM),and further support the registration of new TCM drugs.METHODS:Generalized Boosted Models ...; 关键词：machine learning human clinical experience personalized pharmacotherapy new drugs registration

Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression: 《World Journal of Psychiatry》2025年第1期32-36,共5页Min Xu Hai-Ying Jin Feng-Li Sun Wei-Dong Jin; Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines stil...; 关键词：Child depression Adolescent depression ANTIDEPRESSANT Switch SUICIDE Non-suicidal self injury

Comprehensive bibliometric analysis of pharmacotherapy for bipolar disorders:Present trends and future directions: 《World Journal of Psychiatry》2025年第1期153-167,共15页Bo-Fan Chen Li Liu Fang-Zhen Lin Hai-Min Zeng Hai-Qiang Huang Chun-Fang Zhang Cong-Cong Liu Xiang Chen Jie Peng Yun-Fa Wang Zhi-Lin Wang Bin Chen De-Le Liu Yun Liu Zheng-Zheng Li Xin-Xing Zeng; Supported by the National College Students’Innovative Entrepreneurial Training Plan Program,No.202410403067;the Innovation and Entrepreneurship Training Program for College Students in Jiangxi Province,No.S202410403035.; BACKGROUND Bipolar disorder(BD)is a severe mental illness characterized by significant mood swings.Effective drug treatment modalities are crucial for managing BD.AIM To analyze the current status and future trends of...; 关键词：Bipolar disorder Drug treatment Bibliometric analysis VISUALIZATION Mental disorder

Exploring the therapeutic potential of glucagon-like peptide 1agonists in metabolic disorders: 《World Journal of Gastroenterology》2025年第4期169-175,共7页Adrián Cortés-Martín Julio Plaza-Diaz; This article comments on the work by Soresi and Giannitrapani.The authors have stated that one of the most novel and promising treatments for metabolic dysfunction-associated steatotic liver disease(MASLD)is the use o...; 关键词：Glucagon-like peptide 1 agonists Liver diseases Metabolic dysfunctionassociated steatotic liver disease Metabolic health PHARMACOTHERAPY Diet Gut microbiome Physical exercise LIFESTYLE Non-alcoholic fatty liver disease

Regression of hepatic fibrosis after pharmacological therapy for nonalcoholic steatohepatitis: 《World Journal of Gastrointestinal Pharmacology and Therapeutics》2024年第6期18-27,共10页Mohamed Abdel-Samiee Essam Salah Ibrahim Mohamed Kohla Eman Abdelsameea Mohsen Salama; The global incidence of nonalcoholic fatty liver disease(NAFLD)is escalating considerably.NAFLD covers a range of liver conditions from simple steatosis to the more severe form known as nonalcoholic steatohepatitis,wh...; 关键词：Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis MYOFIBROBLASTS FIBROSIS Antifibrotic pharmacotherapy Nonalcoholic fatty liver disease treatment strategies Emerging treatments for nonalcoholic steatohepatitis

Drug treatment for metabolic dysfunction-associated steatotic liver disease:Progress and direction: 《Chinese Medical Journal》2024年第22期2687-2696,共10页Da Zhou Jiangao Fan; supported by grants from the National Science and Technology Major Project of China(No.2023ZD0508700);the National Natural Science Foundation of China(No.82170593).; Metabolic dysfunction-associated steatotic liver disease(MASLD),also called non-alcoholic fatty liver disease,is the most epidemic chronic liver disease worldwide.Metabolic dysfunction-associated steatohepatitis(MASH)...; 关键词：Metabolic dysfunction-associated steatotic liver disease Metabolic dysfunction-associated steatohepatitis Non-alcoholic steatohepatitis Non-alcoholic fatty liver disease PHARMACOTHERAPY Clinical trial

Pharmacotherapy for the core symptoms of autism spectrum disorder: 《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第11期956-971,共16页Peiying TAN Xiaolin SHEN Lizhang ZENG Xuchu WENG Hongyan GENG; supported by the Key-Area Research and Development Program of Guangdong Province(No.2019B030335001);the National Natural Science Foundation of China(No.32200815);the National Social Science Foundation of China(No.20&ZD296);the China Postdoctoral Science Foundation(No.2022M721218)。; Autism spectrum disorder(ASD)is a range of neurodevelopmental diseases characterized by social dysfunction and stereotypic behaviors.The etiology of ASD remains largely unexplored,resulting in a diverse array of descr...; 关键词：Autism spectrum disorder(ASD) Core symptom PHARMACOTHERAPY Repetitive behaviors Social dysfunction

Potential therapeutic strategies for MASH: from preclinical to clinical development: 《Life Metabolism》2024年第5期45-60,共16页Zhifu Xie Yufeng Li Long Cheng Yidan Huang Wanglin Rao Honglu Shi Jingya Li; supported by grants from the National Natural Science Foundation of China(92057116 to J.L.;82170872 to Z.X.,and 82200965 to Y.L.);the Natural Science Foundation of Shanghai’s 2021“Science and Technology Innovation Action Plan”(21ZR1475300 to Z.X.);Shanghai Science and Technology Development Funds(22YF1456900 to Y.L.).; Current treatment paradigms for metabolic dysfunction-associated steatohepatitis(MASH)are based primarily on dietary restrictions and the use of existing drugs,including anti-diabetic and anti-obesity medications.Give...; 关键词：STEATOSIS inflammation FIBROSIS metabolic dysfunction-associated steatohepatitis PHARMACOTHERAPY

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