Pharmacotherapy for the core symptoms of autism spectrum disorder  

作　　者：Peiying TAN Xiaolin SHEN Lizhang ZENG Xuchu WENG Hongyan GENG 

机构地区：[1]Key Laboratory of Brain,Cognition and Education Sciences,Ministry of Education,South China Normal University,Guangzhou,510631,China [2]Institute for Brain Research and Rehabilitation,and Guangdong Key Laboratory of Mental Health and Cognitive Science,South China Normal University,Guangzhou,510631,China

出　　处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第11期956-971,共16页浙江大学学报（英文版）B辑（生物医学与生物技术）

基　　金：supported by the Key-Area Research and Development Program of Guangdong Province(No.2019B030335001);the National Natural Science Foundation of China(No.32200815);the National Social Science Foundation of China(No.20&ZD296);the China Postdoctoral Science Foundation(No.2022M721218)。

摘　　要：Autism spectrum disorder(ASD)is a range of neurodevelopmental diseases characterized by social dysfunction and stereotypic behaviors.The etiology of ASD remains largely unexplored,resulting in a diverse array of described clinical manifestations and varying degrees of severity.Currently,there are no drugs approved by a supervisory organization that can effectively treat the core symptoms of ASD.Childhood and adolescence are crucial stages for making significant achievements in ASD treatment,necessitating the development of drugs specifically for these periods.Based on the drug targets and mechanisms of action,it can be found that atypical psychotropic medications,anti-inflammatory and antioxidant medications,hormonal medications,ion channel medications,and gastrointestinal medications have shown significant improvement in treating the core symptoms of ASD in both children and adolescents.In addition,comparisons of drugs within the same category regarding efficacy and safety have been made to identify better alternatives and promote drug development.While further evaluation of the effectiveness and safety of these medications is needed,they hold great potential for widespread application in the clinical treatment of the principal symptoms of ASD.

关 键 词：Autism spectrum disorder(ASD) Core symptom PHARMACOTHERAPY Repetitive behaviors Social dysfunction 

分 类 号：R749.94[医药卫生—神经病学与精神病学]