FIBROSIS

作品数：998被引量：4943H指数：29
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相关作者：张松英郭美姿李孝生徐海荣梅浙川更多>>
相关机构：第四军医大学西京医院浙江大学医学院附属第一医院浙江大学医学院附属邵逸夫医院大连医科大学更多>>
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相关基金：国家自然科学基金国家重点基础研究发展计划中国博士后科学基金广东省自然科学基金更多>>
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Transcription factors,metabolic dysfunction-associated fatty liver disease,and therapeutic implications
《Genes & Diseases》2025年第3期137-145,共9页Shuwei Hu Yingjie Ai Chencheng Hu Fathima N.Cassim Bawa Yanyong Xu 
supported by the National Natural Science Foundation of China(No.32271218 to Y.X.).
Metabolic dysfunction-associated fatty liver disease(MAFLD)encompasses a spectrum of liver diseases ranging from metabolic dysfunction-associated fatty liver to metabolic dysfunction-associated steatohepatitis,which m...
关键词：Apoptosis FIBROSIS Inflammation MAFLD STEATOSIS Transcription factors 
MiR-29a-3p inhibits fibrosis of diabetic kidney disease in diabetic mice via downregulation of DNA methyl transferase 3A and 3B
《World Journal of Diabetes》2025年第4期189-204,共16页Ying Yang Yi Chen Jian-Ying Tang Jian Chen Gui-Qing Li Bing Feng Jiao Mu 
Supported by the Chongqing Basic Research and Frontier Exploration Project,No.cstc2018jcyjAX0834.
BACKGROUND At present,the incidence of diabetic nephropathy is increasing year by year,and there are many studies on the pathogenesis of diabetic nephropathy,but it is still not completely clear.The final pathological...
关键词：Diabetic kidney disease Mir-29a-3p DNA methylation Janus kinase/signal transducer and activator of transcription WNT/Β-CATENIN Renal fibrosis 
MicroRNA-122-5p is upregulated in diabetic foot ulcers and decelerates the transition from the inflammatory to the proliferative stage
《World Journal of Diabetes》2025年第4期236-251,共16页Mei-Jie Yuan He-Chen Huang Hong-Shuo Shi Xiao-Ming Hu Zhuo Zhao Yu-Qi Chen Wei-Jing Fan Jian Sun Guo-Bin Liu 
Supported by the National Natural Science Foundation of China,No.82274528.
BACKGROUND Shifting from the inflammatory to the proliferative phase represents a pivotal step during managing diabetic foot ulcers(DFUs);however,existing medical interventions remain insufficient.MicroRNAs(miRs)highl...
关键词：MicroRNA-122-5p Diabetic foot ulcer Wound healing INFLAMMATION FIBROSIS 
Autophagy in erectile dysfunction:focusing on apoptosis and fibrosis
《Asian Journal of Andrology》2025年第2期166-176,共11页Pei-Yue Luo Jun-Rong Zou Tao Chen Jun Zou Wei Li Qi Chen Le Cheng Li-Ying Zheng Biao Qian 
supported by the Health Commission Research Project of China(No.HDSL202001057);the Jiangxi Provincial Health Commission Research Project(No.SKJP20203656);the Doctoral Start-up Fund of the First Affiliated Hospital of Gannan Medical University(No.QD063).
In most types of erectile dysfunction,particularly in advanced stages,typical pathological features observed are reduced parenchymal cells coupled with increased tissue fibrosis.However,the current treatment methods h...
关键词：APOPTOSIS AUTOPHAGY erectile dysfunction FIBROSIS oxidative stress 
Pdgfrα+stromal cells,a key regulator for tissue homeostasis and dysfunction in distinct organs
《Genes & Diseases》2025年第2期181-201,共21页Xia Kang Kun Zhao Zhu Huang So-ichiro Fukada Xiao-wei Qi Hongming Miao 
supported by grants from the National Natural Science Foundation of China (No.82173134 to H.M.);the Sichuan Science and Technology Program (China) (No.2023ZYD0061 to X.K.);the funding of Jinfeng Laboratory (Chongqing,China);China Postdoctoral Science Foundation (No.2020M673648 to X.K.);Chongqing Postdoctoral Science Special Foundation (China) (to X.K.);Chongqing Science and Technology Bureau (China) (No.CSTB2022TIADKPX0168 to X.Q.).
Pdgfra+stromal cells are a group of cells specifically expressing Pdgfra,which may be mentioned with distinct names in different tissues.Importantly,the findings from numerous studies suggest that these cells share ex...
关键词：Fatty infiltration FIBROSIS Pdgfra^(+)stromal cell Tissue degeneration Tissue regeneration 
Antibiotic-Depleted Lung Microbiota Modulates Surfactant Proteins Expression and Reduces Experimental Silicosis
《Biomedical and Environmental Sciences》2025年第4期469-483,共15页Qiang Zhou Meiyu Chang Ning Li Yi Guan Sanqiao Yao 
supported by the National Natural Science Foundation of China Joint Fund for Regional Innovation and Development(Grant numbers [U21A20334]);the Postgraduate Innovation Funding Project of Hebei Province(Grant numbers [CXZZBS2022116])。
Objective Recent studies have overturned the traditional concept of the lung as a “sterile organ” revealing that pulmonary microbiota dysbiosis and abnormal surfactant proteins(SPs) expression are involved in the pr...
关键词：16s rRNA sequencing FIBROSIS Lung microbiota ANTIBIOTICS Surfactant proteins 
Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis
《Genes & Diseases》2025年第2期383-397,共15页Changyuan Huangg Bin Zeng Bo Zhou Guanming Chen Qi Zhang Wenhong Hou Guozhi Xiao Li Duan Ni Hong Wenfei Jin 
supported by the National Key R&D Program of China (No.2021YFF1200900);National Natural Science Foundation of China (No.32170646,8197211);Guangdong Basic and Applied Basic Research Foundation (China) (No.2023A1515011908 to N.H.);Key-Area Research and Development Program of Guangdong Province,China (No.2023B1111020006);International Science and Technology CooperationnProgramnofGuangdong,China (No.2021A0505030011);Shenzhen Innovation Committee of Science and Technology (Guangdong,China) (No.JCYJ20220818100401003);Shenzhen Science and Technology Program (Guangdong,China) (No.SGDX20201103095800003,GJHZ20200731095606019,JCYJ20220818100401003);Shenzhen High-level Hospital Construction Fund (Guangdong,China) (No.1801004).
Chondrocyte is considered the only cell type in cartilage.However,the cell hetero-geneity of chondrocytes in human articular cartilage is still not well defined,which hinders our understanding of the pathogenesis of o...
关键词：Cell heterogeneity Chondrocyte apoptosis Chondrocyte differentiation Chondrocyte fibrosis OSTEOARTHRITIS Single-cell RNA-seq 
Tongmai Hypoglycemic Capsule Attenuates Myocardial Oxidative Stress and Fibrosis in the Development of Diabetic Cardiomyopathy in Rats
《Chinese Journal of Integrative Medicine》2025年第3期251-260,共10页ZENG Jie-qiong ZHOU Hui-fen DU Hai-xia WU Yu-jia MAO Qian-ping YIN Jun-jun WAN Hai-tong YANG Jie-hong 
Supported by National Key R&D Program for Modernization of Traditional Chinese Medicine(No.2018YFC1704204)。
Objective:To investigate the effect of Tongmai Hypoglycemic Capsule(THC)on myocardium injury in diabetic cardiomyopathy(DCM)rats.Methods:A total of 24 Sprague Dawley rats were fed for 4 weeks with highfat and high-sug...
关键词：Tongmai Hypoglycemic Capsule oxidative stress Nrf2 element myocardial fibrosis diabetic cardiomyopathy 
Diagnostic performance of FibroTest-ActiTest,transient elastography,and the fibrosis-4 index in patients with autoimmune hepatitis using histological reference
《World Journal of Hepatology》2025年第3期116-129,共14页Valentina Peta Yuliya Sandler Olivier Deckmyn Oksana Duroselle Elena Vinnitskaya Sergey Khomeriki Karina Noskova Thierry Poynard 
BACKGROUND Noninvasive tests are crucial for the management and follow-up of patients with autoimmune hepatitis,but their validation is limited because of insufficient data.AIM To investigate the diagnostic performanc...
关键词：Autoimmune hepatitis FibroTest FibroSure ActiTest Fibrosis-4 index FIBROSIS Vibration-controlled transient elastography 
NR4A1 silencing alleviates high-glucose-stimulated HK-2 cells pyroptosis and fibrosis via hindering NLRP3 activation and PI3K/AKT pathway
《World Journal of Diabetes》2025年第3期203-215,共13页Jin-Meng Li Zi-Hua Song Yuan Li Han-Wen Chen Han Li Lu Yuan Jing Li Wen-Yue Lv Lei Liu Na Wang 
Supported by Research Fund for Academician Lin He New Medicine,No.JYHL2022FMS02.
BACKGROUND The pathophysiology of diabetic kidney disease(DKD)is complex.Interfering with the processes of pyroptosis and fibrosis is an effective strategy for slowing DKD progression.Previous studies have revealed th...
关键词：Diabetes Diabetic kidney disease PYROPTOSIS FIBROSIS Nuclear receptor subfamily 4 group A member 1 
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