Autophagy in erectile dysfunction:focusing on apoptosis and fibrosis  

作　　者：Pei-Yue Luo Jun-Rong Zou Tao Chen Jun Zou Wei Li Qi Chen Le Cheng Li-Ying Zheng Biao Qian 

机构地区：[1]The First Clinical College,Gannan Medical University,Ganzhou 341000,China [2]Department of Urology,The First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China [3]Key Laboratory of Urology and Andrology of Ganzhou,Ganzhou 341000,China [4]Department of Graduate,The First Affiliated Hospital of Gannan Medical University,Ganzhou 341000,China

出　　处：《Asian Journal of Andrology》2025年第2期166-176,共11页亚洲男性学杂志(英文版)

基　　金：supported by the Health Commission Research Project of China(No.HDSL202001057);the Jiangxi Provincial Health Commission Research Project(No.SKJP20203656);the Doctoral Start-up Fund of the First Affiliated Hospital of Gannan Medical University(No.QD063).

摘　　要：In most types of erectile dysfunction,particularly in advanced stages,typical pathological features observed are reduced parenchymal cells coupled with increased tissue fibrosis.However,the current treatment methods have shown limited success in reversing these pathologic changes.Recent research has revealed that changes in autophagy levels,along with alterations in apoptosis and fibrosis-related proteins,are linked to the progression of erectile dysfunction,suggesting a significant association.Autophagy,known to significantly affect cell fate and tissue fibrosis,is currently being explored as a potential treatment modality for erectile dysfunction.However,these present studies are still in their nascent stage,and there are limited experimental data available.This review analyzes erectile dysfunction from a pathological perspective.It provides an in-depth overview of how autophagy is involved in the apoptotic processes of smooth muscle and endothelial cells and its role in the fibrotic processes occurring in the cavernosum.This study aimed to develop a theoretical framework for the potential effectiveness of autophagy in preventing and treating erectile dysfunction,thus encouraging further investigation among researchers in this area.

关 键 词：APOPTOSIS AUTOPHAGY erectile dysfunction FIBROSIS oxidative stress 

分 类 号：R697[医药卫生—泌尿科学]