Pdgfrα+stromal cells,a key regulator for tissue homeostasis and dysfunction in distinct organs  

作　　者：Xia Kang Kun Zhao Zhu Huang So-ichiro Fukada Xiao-wei Qi Hongming Miao 

机构地区：[1]Department of Pathophysiology,College of High Altitude Military Medicine,Army Medical University,Chongqing 400038,China [2]Pancreatic Injury and Repair Key Laboratory of Sichuan Province,The General Hospital of Western Theater Command,Chengdu,Sichuan 610000,China [3]Project for Muscle Stem Cell Biology,Graduate School of Pharmaceutical Sciences,Osaka University,Suita,Osaka 564-0871,Japan [4]Department of Breast and Thyroid Surgery,Southwest Hospital,Army Medical University,Chongqing 400038,China [5]Jinfeng Laboratory,Chongqing 401329,China

出　　处：《Genes & Diseases》2025年第2期181-201,共21页基因与疾病(英文)

基　　金：supported by grants from the National Natural Science Foundation of China (No.82173134 to H.M.);the Sichuan Science and Technology Program (China) (No.2023ZYD0061 to X.K.);the funding of Jinfeng Laboratory (Chongqing,China);China Postdoctoral Science Foundation (No.2020M673648 to X.K.);Chongqing Postdoctoral Science Special Foundation (China) (to X.K.);Chongqing Science and Technology Bureau (China) (No.CSTB2022TIADKPX0168 to X.Q.).

摘　　要：Pdgfra+stromal cells are a group of cells specifically expressing Pdgfra,which may be mentioned with distinct names in different tissues.Importantly,the findings from numerous studies suggest that these cells share exactly similar biomarkers and properties,show complex functions in regulating the microenvironment,and are critical to tissue regeneration,repair,and degeneration.Comparing the similarities and differences between distinct tissue-resident Pdgfra+stromal cells is helpful for us to more comprehensively and deeply understand the be-haviors of these cells and to explore some common regulating mechanisms and therapeutical targets.In this review,we summarize previous and current findings on Pdgfra+stromal cells in various tissues and discuss the crosstalk between Pdgfra+stromal cells and microenvironment.

关 键 词：Fatty infiltration FIBROSIS Pdgfra^(+)stromal cell Tissue degeneration Tissue regeneration 

分 类 号：R73[医药卫生—肿瘤]