Negative efficacy of antidepressants in pharmacotherapy of child and adolescent depression  

作　　者：Min Xu Hai-Ying Jin Feng-Li Sun Wei-Dong Jin 

机构地区：[1]Department of Psychiatry,Zhejiang Chinese Medical University,Hangzhou 310053,Zhejiang Province,China [2]Department of Psychiatry,Tongde Hospital of Zhejiang Province,Hangzhou 310012,Zhejiang Province,China [3]Department of Psychiatry,Zhejiang Provincial Mental Health Center,Hangzhou 311122,Zhejiang Province,China

出　　处：《World Journal of Psychiatry》2025年第1期32-36,共5页世界精神病学杂志（英文）

摘　　要：Antidepressants are the main drugs used to treat depression,but they have not been shown to be effective in the treatment of child and adolescent depression.However,many adolescent depression treatment guidelines still recommend the use of antidepressants,especially specific serotonin re-uptake inhibitors.Previous studies have suggested that antidepressants have little therapeutic effect but many side effects,such as switching to mania,suicide,and non-suicidal self injury(NSSI),in the treatment of child and adolescent depression.In the process of developing guidelines,drug recommendations should not only focus on impro-ving symptoms,but they should also consider potential side effects.This review discusses the serious side effects of antidepressants,including switching to mania,suicide,and NSSI.

关 键 词：Child depression Adolescent depression ANTIDEPRESSANT Switch SUICIDE Non-suicidal self injury 

分 类 号：R749.4[医药卫生—神经病学与精神病学]