MYOFIBROBLASTS

作品数：38被引量：204H指数：8
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相关领域：医药卫生更多>>
相关作者：王鹏谢举临更多>>
相关机构：中山大学附属第一医院中国医科大学更多>>
相关期刊：《Hepatobiliary & Pancreatic Diseases International》《Chinese Medical Journal》《World Journal of Cardiology》《World Journal of Hepatology》更多>>
相关基金：国家自然科学基金河北省自然科学基金广东省自然科学基金中国博士后科学基金更多>>
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Regression of hepatic fibrosis after pharmacological therapy for nonalcoholic steatohepatitis
《World Journal of Gastrointestinal Pharmacology and Therapeutics》2024年第6期18-27,共10页Mohamed Abdel-Samiee Essam Salah Ibrahim Mohamed Kohla Eman Abdelsameea Mohsen Salama 
The global incidence of nonalcoholic fatty liver disease(NAFLD)is escalating considerably.NAFLD covers a range of liver conditions from simple steatosis to the more severe form known as nonalcoholic steatohepatitis,wh...
关键词：Nonalcoholic fatty liver disease Nonalcoholic steatohepatitis MYOFIBROBLASTS FIBROSIS Antifibrotic pharmacotherapy Nonalcoholic fatty liver disease treatment strategies Emerging treatments for nonalcoholic steatohepatitis 
Understanding myofibroblast origin in the fibrotic lung
《Chinese Medical Journal Pulmonary and Critical Care Medicine》2024年第3期142-150,共9页Mahsa Zabihi Mahtab Shahriari Felordi Arun Lingampally Saverio Bellusci Xuran Chu Elie El Agha 
B was supported by grants from the German Research Foundation(DFG;Nos.BE 4443/1-1,BE 4443/4-1,BE4443/6-1,KFO309284237345 P7 and CRC1213268555672 projects A02 and A04);German Center for Lung Research(DZL),and Excellence Cluster CardioPulmonary Institute(CPI;No.EXC2026390649896);XC acknowledges the support of the Natural Science Foundation of Zhejiang Grant(No.LQ24H210001);EEA was supported by the DFG(Nos.EL 931/5-1,EL 931/4-1,KFO309284237345 P7 and SFB CRC1213268555672 project A04),Institute for Lung Health(ILH),CPI,and DZL.
Idiopathic pulmonary fibrosis(IPF)is characterized by accumulation of myofibroblasts(MYFs)and extracellular matrix components,which leads to severe distortion and scarring of the gas exchange units of the lung,the alv...
关键词：Idiopathic pulmonary fibrosis MYOFIBROBLASTS Fibrotic disease Myofibroblast heterogeneity Lineage tracing 
TL1A Promotes Fibrogenesis in Colonic Fibroblasts via the TGF-β1/Smad3 Signaling Pathway
《Current Medical Science》2024年第3期519-528,共10页Jia SONG Dong-lei SUN Chen-yang LI Yu-xin LUO Qian LIU Yue YAO Hong ZHANG Ting-ting YANG Mei SONG Xin-li BAI Xiao-lan ZHANG 
supported by grants from the National Natural Science Foundation of China(No.82270545 and No.81870381);Natural Science Foundation of Hebei Province(No.H2014206446)。
Objective Intestinal fibrosis is a refractory complication of inflammatory bowel disease(IBD).Tumor necrosis factor ligand-related molecule-1A(TL1A)is important for IBD-related intestinal fibrosis in a dextran sodium ...
关键词：tumor necrosis factor ligand-related molecule-1A fibrosis inflammatory bowel disease MYOFIBROBLASTS transforming growth factor-β1 
Nanotechnology-based combinational strategies toward the regulation of myofibroblasts and diseased microenvironment in liver fibrosis and hepatic carcinoma被引量：1
《Nano Research》2023年第12期13042-13055,共14页Fenfen Li Ying Zhao Guangjun Nie 
sponsored by the National Natural Science Foundation of China(Nos.52173120 and 21877023);the Youth Innovation Promotion Association CAS(No.2021018);the Beijing Natural Science Foundation(No.L222015);the Key Area R&D Program of Guangdong Province(No.2020B0101020004);the Beijing Nova Program(No.20220484233).
Liver fibrosis and hepatic carcinoma(HCC)pose a huge challenge worldwide due to the lack of effective treatment options for end-stage liver diseases.According to their functions and roles,hepatic myofibroblasts mainly...
关键词：FIBROBLASTS liver fibrosis hepatic carcinoma NANOTECHNOLOGY 
Mesenchymal stem cells in fibrotic diseases—the two sides of the same coin被引量：7
《Acta Pharmacologica Sinica》2023年第2期268-287,共20页Lei Qin Nian Liu Chao-le-meng Bao Da-zhi Yang Gui-xing Ma Wei-hong Yi Guo-zhi Xiao Hui-ling Cao 
funded by the National Key Research and Development Program of China Grants(2019YFA0906001);National Natural Science Foundation of China Grants(82022047,81972100);Guangdong Provincial Science and Technology Innovation Council Grant(2017B030301018);project of Huazhong University of Science and Technology Union Shenzhen Hospital(NY2021029,NY2021030,NY2021031).
Fibrosis is caused by extensive deposition of extracellular matrix(ECM)components,which play a crucial role in injury repair.Fibrosis attributes to~45%of all deaths worldwide.The molecular pathology of different fibro...
关键词：fibrotic diseases mesenchymal stem cells MYOFIBROBLASTS liver cirrhosis pulmonary fibrosis 
Pharmacological regulation of tissue fibrosis by targeting the mechanical contraction of myofibroblasts
《Fundamental Research》2022年第1期37-47,共11页Zheng-Quan He Xue-Wei Yuan Zong-Bao Lu Yu-Huan Li Yu-Fei Li Xin Liu Liu Wang Ying Zhang Qi Zhou Wei Li 
the Institute of Zoology,Chinese Academy of Sciences for their technical assistance.This work was supported by grants from the Strategic Priority Research Program of the Chinese Academy of Sciences(XDA16030400 to W.L.);the National Key Research and Development Program(2018YFC1004500 to Y.Z.and 2017YFA0103803 to Q.Z.);the National Natural Science Foundation of China(31621004 to Q.Z.and W.L.);CAS Project for Young Scientists in Basic Research(YSBR-012 to W.L.);the China Postdoctoral Science Foundation(2019M650841 to Z.H.);the National Natural Science Foundation of China(31900510 to Y.L.).
Fibrosis can occur in almost all tissues and organs and affects normal physiological function,which may have serious consequences,such as organ failure.However,there are currently no effective,broad-spectmm drugs suit...
关键词：FIBROSIS MYOFIBROBLASTS CONTRACTION INHIBITOR BIOMECHANICS Regeneration 
Chemokine CCL1 as a therapeutic target for pulmonary fibrosis: comments on ‘The chemokine CCL1 triggers an AMFR‒SPRY1 pathway that promotes differentiation of lung fibroblasts into myofibroblasts and drives pulmonary fibrosis’
《Journal of Molecular Cell Biology》2022年第1期65-66,共2页Shanshan Liu Chang Liu Zhuowei Hu Yang Xiao 
The work described was supported by grants from the National Key R&D Program of China(2018YFE0114500);the‘361 Project’Outstanding Young Talent of the Second Xiangya Hospital of Central South University,the National Natural Science Foundation of China(81803604);the National Science Foundation of Hunan Province for Excellent Young Scholars(2020JJ3056).
Pulmonary fibrosis(PF)is a type of chronic and progressive respiratory diseases characterized by excessive extracellular matrix(ECM)deposition,interstitial fibrotic lesions,and architectural distortion.Patients with P...
关键词：THERAPEUTIC lung DRUGS 
Stromal and Tumor Glioma-derived Cells with Similar Characteristics Have Differences in α-Smooth Muscle Actin Expression and Localization
《Journal of Oncology Research》2021年第2期8-21,共14页I.Gin I.Chistyakova V.Zenin S.Koshkin A.Musorina Y.Lahina G.Timin V.Pospelov S.Prikhodko A.Petukhov E.Tolkunova 
The design of this study and analysis of data were fi­nancially supported by the grants from Russian Science Foundation(No.18-75-10076)and by RFBR(No.19-315-51035).
Gliomas are solid brain tumors composed of tumor cells and recruited heterogenic stromal components.The study of the interactions between the perivascular niche and its surrounding cells is of great value in unravelin...
关键词：OLIGODENDROGLIOMA ASTROCYTOMA Primary cell cultures Tumor microenvironment MYOFIBROBLASTS Extracellular matrix 
Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases被引量：6
《Hepatobiliary & Pancreatic Diseases International》2021年第4期315-322,共8页Devaraj Ezhilarasan 
Background: Upon liver injury, quiescent hepatic stellate cells(q HSCs), reside in the perisinusoidal space, phenotypically transdifferentiate into myofibroblast-like cells(MFBs). The q HSCs in the normal liver are le...
关键词：Hepatic stellate cells GLUTAMINOLYSIS GLYCOLYSIS HEDGEHOG MYOFIBROBLASTS 
Botulinum Toxin Type A and Its Possible Mechanisms on Wound Healing
《Modern Plastic Surgery》2020年第3期38-55,共18页Khushboo Gurung Qian Tan Ye Xu Bingchen Duan 
Botulinum toxin type-A (BTX-A), a subtype from known seven types of botulinum neurotoxin (serotype A-G), is produced by a gram-positive bacterium, Clostridium botulinum. The toxin is now widely and efficiently ...
关键词：Wound Healing Botulinum Toxin Type-A Hypertrophic Scar KELOID FIBROBLAST MYOFIBROBLASTS Transforming Growth Factor β-1 Collagen METALLOPROTEINASES Connective Tissue Growth Factor 
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