GLUTAMINOLYSIS

作品数：13被引量：55H指数：5
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相关领域：医药卫生更多>>
相关作者：武海丽杨鹏李宗伟李卓玉更多>>
相关机构：山西大学更多>>
相关期刊：《Journal of Clinical and Translational Hepatology》《Cancer Biology & Medicine》《Science China(Life Sciences)》《Acta Pharmacologica Sinica》更多>>
相关基金：国家自然科学基金国家重点基础研究发展计划更多>>
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l-[5-^(11)C]Glutamine PET imaging noninvasively tracks dynamic responses of glutaminolysis in non-alcoholic steatohepatitis Author links open overlay panel
《Acta Pharmaceutica Sinica B》2025年第2期681-691,共11页Yiding Zhang Lin Xie Masayuki Fujinaga Yusuke Kurihara Masanao Ogawa Katsushi Kumata Wakana Mori Tomomi Kokufuta Nobuki Nengaki Hidekatsu Wakizaka Rui Luo Feng Wang Kuan Hu Ming-Rong Zhang 
supported in part by the Moonshot Research and Development Program(Grant No.21zf0127003h001,Japan);JSPS A3 Foresight Program(Grant No.JPJSA3F20230001,Japan);JSPS KAKENHI(Grants No.23H02867,23H05487,and 21K07659,Japan).
Inhibiting glutamine metabolism has been proposed as a potential treatment strategy for improving non-alcoholic steatohepatitis(NASH).However,effective methods for assessing dynamic metabolic responses during interven...
关键词：l-[5-^(11)C]Glutamine Positron emission tomography Non-alcoholic steatohepatitis GLUTAMINOLYSIS Glutaminase 1 Metabolic intervention BPTES therapy 
Fueling metabolic adaptation: lysosomal AMPK ignites glutaminolysis
《Cell Research》2024年第12期822-823,共2页Benoit Viollet Bruno Guigas 
The capacity to effectively adapt metabolism to environmental demands is crucial for cell viability,proliferation,and function.Recent discoveries in Cell Research have highlighted the role of the lysosomal pool of AMP...
关键词：METABOLISM function. LYSOSOMAL 
Inhibition of glutaminolysis alone and in combination with HDAC inhibitor has anti-myeloma therapeutic effects
《Cancer Drug Resistance》2024年第1期604-619,共16页Seiichi Okabe Yuko Tanaka Mitsuru Moriyama Akihiko Gotoh 
approved by the Ethics Committee of Tokyo Medical University(No.T2023-0105).
Aim:This study aimed to investigate drug candidates and their efficacy in treating refractory multiple myeloma(MM)despite significant therapeutic advances and the introduction of novel agents.Our study focused on how ...
关键词：Multiple myeloma GLUTAMINOLYSIS GLS1 HDAC inhibitor 
A comprehensive overview of recent developments on the mechanisms and pathways of ferroptosis in cancer: the potential implications for therapeutic strategies in ovarian cancer
《Cancer Drug Resistance》2023年第3期547-566,共20页Hiroshi Kobayashi Chiharu Yoshimoto Sho Matsubara Hiroshi Shigetomi Shogo Imanaka 
supported by Japan Society for the Promotion of Science,Japan(Grant Number:23K08806).
Cancer cells adapt to environmental changes and alter their metabolic pathways to promote survival and proliferation. Metabolic reprogramming not only allows tumor cells to maintain a reduction-oxidation balance by re...
关键词：Ferroptosis GLUTAMINOLYSIS GLYCOLYSIS metabolic vulnerability ovarian cancer pentose phosphate pathway 
O-GlcNAcylation Coordinates Glutaminolysis by Regulating the Stability and Membrane Trafficking of ASCT2 in Hepatic Stellate Cells
《Journal of Clinical and Translational Hepatology》2022年第6期1107-1116,共10页Feixia Wang Li Chen Biyun Zhang Zhanghao Li Min Shen Li Tang Zili Zhang Jiangjuan Shao Feng Zhang Shizhong Zheng Shanzhong Tan 
the Leading Talent Project of Ji-angsu Province Traditional Chinese Medicine(SLJ0216);the National Natural Science Foundation of China(82073914,81870423);the Major Project of the Natural Science Research of Jiangsu Higher Education Institutions(19KJA310005);the Postgraduate Research&Practice Innovation Program of Jiangsu Province,Grant/Award Number:KYCX20_1493;the Joint Project of Jiangsu Key Laboratory for Pharmacol-ogy and Safety Evaluation of Chinese Materia Medica and Yangtze River Pharmaceutical(JKLPSE202005)。
Background and Aims:Recognition of excessive activa-tion of hepatic stellate cells(HSCs)in liver fibrosis prompt-ed us to investigate the regulatory mechanisms of HSCs.We aimed to examine the role of O-GlcNAcylation m...
关键词：ASCT2 O-GLCNACYLATION Stability TRAFFICKING Liver fibrosis 
Glutaminolysis-ammonia-urea Cycle Axis,Non-alcoholic Fatty Liver Disease Progression and Development of Novel Therapies
《Journal of Clinical and Translational Hepatology》2022年第2期356-362,共7页Ángela Rojas María Rosario García-Lozano Antonio Gil-Gómez Manuel Romero-Gómez Javier Ampuero 
funded in part by the Spanish Ministry of Economy,Innovation and Competition,Instituto de Salud Carlos III(PI19/00589,PI19/01404,PI16/01842,PI17/00535 and GLD19/00100).
The prevalence of non-alcoholic fatty liver disease(NAFLD)is increasing worldwide,reflecting the current epidemics of obesity,insulin resistance,type 2 diabetes mellitus,and metabolic syndrome.NAFLD is characterized b...
关键词：Non-alcoholic fatty liver disease CIRRHOSIS FIBROSIS Glutaminoly-sis AMMONIA UREA 
Bergenin, a PPARγ agonist, inhibits Th17 differentiation and subsequent neutrophilic asthma by preventing GLS1-dependent glutaminolysis被引量：7
《Acta Pharmacologica Sinica》2022年第4期963-976,共14页Ling Yang Yun Zheng Yu-meng Miao Wen-xin Yan Yan-zhi Geng Yue Dai Zhi-feng Wei 
This work was supported by the National Natural Science Foundation of China(No.81773970);the 2019 Outstanding Young Backbone Teacher Project of Jiangsu University“Green Blue Project”.
Bergenin is a natural PPARγ agonist that can prevent neutrophil aggregation, and often be used in clinics for treating respiratory diseases. Recent data show that Th17 cells are important for neutrophil aggregation a...
关键词：immunity-related diseases neutrophilic asthma Th17 differentiation GLUTAMINOLYSIS GLS1 BERGENIN 
Governing glutaminolysis by regulation of glutaminase succinylation
《Protein & Cell》2022年第3期163-166,共4页Qingxia Ma Hongfei Jiang Leina Ma Ying Meng Dong Guo Yingying Tong Zhimin Lu 
This study was supported by grants from Ministry of Science and Technology of the People's Republic of China(2020YFA0803300,Z.L.);the National Natural Science Foundation of China(82188102,82030074,Z.L.;81902423,D.G.);the Zhejiang University Research Fund(188020*194221901/029,Z.L.);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2019R01001,Z.L.);the Scientific Research Project of Beijing Municipal Education Commission(KM202110025002,Y.T.).Z.L.is the Kuancheng Wang Distinguished Chair.
Of the 20 ribosomally coded amino acid residues,lysine(K)can be frequently and uniquely modified by many types of posttranslational acylation,including acetylation,succinylation,crotonylation,propionylation,butyrylati...
关键词：uniquely RESIDUES CRITICAL 
Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability被引量：6
《Acta Pharmaceutica Sinica B》2022年第2期759-773,共15页Jing Shi Rui Ju Hongting Gao Yuqing Huang Lei Guo Dechang Zhang 
supported by the National Natural Science Foundation of China(grants 81872897 and 81672966);the CAMS Major Collaborative Innovation Project 2016-I2 M-1-011(China)。
Tumor cells have unique metabolic programming that is biologically distinct from that of corresponding normal cells.Resetting tumor metabolic programming is a promising strategy to ameliorate drug resistance and impro...
关键词：CAI GLUTAMINOLYSIS Glutamine metabolism AHR Colorectal cancer metabolism Mitochondrial oxidative stress Redox homeostasis Metabolic reprogramming 
Mitochondria: A critical hub for hepatic stellate cells activation during chronic liver diseases被引量：6
《Hepatobiliary & Pancreatic Diseases International》2021年第4期315-322,共8页Devaraj Ezhilarasan 
Background: Upon liver injury, quiescent hepatic stellate cells(q HSCs), reside in the perisinusoidal space, phenotypically transdifferentiate into myofibroblast-like cells(MFBs). The q HSCs in the normal liver are le...
关键词：Hepatic stellate cells GLUTAMINOLYSIS GLYCOLYSIS HEDGEHOG MYOFIBROBLASTS 
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