云南高校图书馆联盟文献共享服务平台- AHR

检索规则说明：AND代表“并且”；OR代表“或者”；NOT代表“不包含”；(注意必须大写,运算符两边需空一格)

检索范例：范例一： (K=图书馆学 OR K=情报学) AND A=范并思　　　　范例二：J=计算机应用与软件 AND (U=C++ OR U=Basic) NOT M=Visual

全部期刊核心期刊 EI来源期刊 SCI来源期刊 CA来源期刊 CSCD来源期刊 CSSCI来源期刊

钱塘江地表水有机微污染物AhR效应分析: 《浙江大学学报(理学版)》2025年第2期263-274,共12页万奇霖刘瑶洪文俊应林浩姚佳叶铖范思哲方文迪; 国家自然科学基金资助项目(22106157);辐射防护实验室开放基金项目(ZFYHHJMN-2023003);浙江省省级高校基本科研业务费项目.; 钱塘江地表水因受人类强烈活动干扰被检出含有大量有机微污染物,其可能引起水生生物的生理、生化、毒理学效应并威胁生态环境与人类健康,因而广受关注。然而,对钱塘江地表水中有机微污染物的人源芳香烃受体(AhR)效应研究仍然有限。本文...; 关键词：有机微污染物基于生物效应的评估方法芳香烃受体效应毒性贡献率

S100a8、S100a9在支气管哮喘发生机制中的研究进展: 《中国免疫学杂志》2025年第3期704-708,共5页袁小慧陈莉延; 重大慢性非传染性疾病防控研究重点专项(2018YFC1311403);国家自然科学基金面上项目(81470221);广东省自然科学基金(2017A030313811);广东省教育厅研究生教育创新计划项目(2017JGXM-MS48);呼吸疾病国家重点实验室自主课题(青年项目)(SKLRD-QN-201701)。; S100a8和S100a9蛋白是S100蛋白家族的重要成员,可通过激活细胞内信号级联反应诱导炎症产生,同时其强大的钙离子结合能力使其在调控细胞收缩方面发挥重要作用。S100a8和S100a9不仅参与调节哮喘气道炎症,而且对哮喘气道高反应也具有保护...; 关键词：S100A8 S100A9 哮喘 AHR

核受体PXR/AhR调控药物代谢酶对神经系统解毒机理研究进展: 《江西中医药》2025年第2期85-88,共4页薛锦左铮云陈丽华; 国家自然科学基金项目(82160752)。; PXR/AhR作为一种重要的转录因子,在神经系统的解毒机理中发挥着关键作用,通过调控解毒酶基因表达、介导药物代谢及与其他转录因子的相互作用,来影响药物的解毒过程。PXR/AhR激活后,可以正向调控下游的代谢酶(如Ⅰ相代谢酶CYP3A、CYP2C、...; 关键词：核受体孕烷X受体芳香烃核受体神经毒性

Gut microbiota-derived tryptophan metabolites regulated by Wuji Wan to attenuate colitis through AhR signaling activation: 《Acta Pharmaceutica Sinica B》2025年第1期205-223,共19页Wanghui Jing Sijing Dong Yinyue Xu Jingjing Liu Jiawei Ren Xue Liu Min Zhu Menggai Zhang Hehe Shi Na Li Peng Xia Haitao Lu Sicen Wang; supported by the National Natural Scientific Foundation of China(82174059);Outstanding young and middleaged science and technology talents of Shaanxi Administration of Traditional Chinese Medicine(2023-ZQNY-004,China);the Natural Science Foundation of Shaanxi Province(2022SF-123,China);Innovative talent team introduction project in Xinzhou City(20220701,China);the Project of Shaanxi Administration of Traditional Chinese Medicine(No.2022-SLRH-YQ-001,China);the SKL-GRF Grant from State Key Laboratory of Environmental and Biological Analysis at Hong Kong Baptist University(SKLP_2425_P02,China).; Disruption of the intestinal mucosal barrier caused by gut dysbiosis and metabolic imbalance is the underlying pathology of inflammatory bowel disease(IBD).Traditional Chinese medicine Wuji Wan(WJW)is commonly used to...; 关键词：Wuji Wan COLITIS Gut microbiota Tryptophan metabolite Intestinal barrier Aryl hydrocarbon receptor Indole-3-acetic acid

Discovery of a novel AhReCYP1A1 axis activator for mitigating inflammatory diseases using an in situ functional imaging assay: 《Acta Pharmaceutica Sinica B》2025年第1期508-525,共18页Feng Zhang Bei Zhao Yufan Fan Lanhui Qin Jinhui Shi Lin Chen Leizhi Xu Xudong Jin Mengru Sun Hongping Deng Hairong Zeng Zhangping Xiao Xin Yang Guangbo Ge; supported by National Natural Science Foundation of China(Nos.U23A20516,81922070,82273897 and 52303191);National Key Research and Development Program of China(No.2022YFC3502000);Shanghai Science and Technology Innovation Action Plans(21S21900600,China);the Organizational Key Research and Development Program of Shanghai University of Traditional Chinese Medicine(No.2023YZZ02,China);Shanghai Municipal Health Commission’s TCM research project(No.2022CX005,China);Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(No.ZYYCXTDD-202004,China);the State Key Laboratory of Fine Chemicals,Dalian University of Technology(No.KF 2202,China);Shanghai University of Traditional Chinese Medicine(No.2021LK023,China).; The aryl hydrocarbon receptor(AhR)plays a crucial role in regulating many physiological processes.Activating the AhReCYP1A1 axis has emerged as a novel therapeutic strategy against various inflammatory diseases.Here,a...; 关键词：Aryl hydrocarbonreceptor(AhR) Cytochrome P4501A1(CYP1A1) In situ functional imaging Ulcerative colitis(UC) Acute lung injury(ALI) Long term imaging Rational design Inflammatory diseases

根尖牙乳头干细胞外泌体通过AHR调节CDC42转录促进血管内皮细胞迁移的机制研究: 《口腔生物医学》2024年第6期313-321,共9页马元庄雪莹祝雪松刘尧陈旭; 国家自然科学基金(82071100)。; 目的:探究根尖牙乳头干细胞来源的外泌体(SCAP-Exo)调控细胞分裂周期蛋白42(CDC42)转录介导血管内皮细胞(VECs)迁移的分子机制。方法:超速离心法提取SCAP-Exo并应用透射电镜和纳米粒子追踪实验鉴定。构建CDC42低表达的VECs,应用SCAP-Ex...; 关键词：根尖牙乳头干细胞外泌体血管内皮细胞细胞迁移细胞分裂周期蛋白42 芳香烃受体

新型AhR激动剂的设计、合成及活性研究: 《药学学报》2024年第11期2997-3005,共9页贾剑敏蔡亚仙韩自省徐佳佳蔡开明胡晓慧; 芳香烃受体(aryl hydrocarbon receptor,AhR)是一种配体激活的转录因子,它在包括免疫细胞和上皮细胞在内的多种细胞中调节基因表达。AhR信号通路在健康和疾病状态下的免疫系统中均发挥着重要作用。Tapinarof目前是全球首个且唯一被批准...; 关键词：芳香烃受体激动剂 Tapinarof 干扰素-Γ 光化学稳定性

AhR和Wnt信号通路的相互作用研究进展: 《海南医学》2024年第21期3171-3176,共6页梁深虎罗健民宋庆高; 国家自然科学基金(编号:82360183);贵州省遵义市联合基金:口腔颌面整形美容创新团队(编号:遵市科合HZ字【2020】294号)。; 人体正常发育与健康状态的维持常依赖于AhR与Wnt信号通路的恰当调节,而两条信号通路一旦失调则会导致发育障碍和疾病。研究表明,虽然AhR和Wnt信号通路在整个进化过程中高度保守,但两条通路之间仍存在着相互作用,其在多种生理过程及疾病...; 关键词：芳基烃受体 WNT 信号通路相互作用研究进展

Skin Rejuvenation in Aged Mice by Fecal Microbiota Transplantation from Young Mice Feces: 《Engineering》2024年第11期26-38,共13页Shoujuan Yu Ziyang Li Xiaoxu Zhang Qi Zhang Liwei Zhang Liang Zhao Ping Liu Jie Guo Juan Chen Chengying Zhang Xinjuan Liu Mengyang Yu Dekui Jin Xiaofeng Wang Guang Li Yan Cao Fazheng Ren Ran Wang; supported in part by grants from the National Key Research and Development Program of China(2021YFD1600204 and 2023YFF1104500);the 111 project from the Ministry of Education of the People’s Republic of China 577(B18053).; Skin aging is an increasingly prominent topic in the context of healthy aging.During the aging process,the skin’s barrier function diminishes,its water content decreases,wrinkles begin to form,and changes occur in th...; 关键词：Skin aging FMT TRYPTOPHAN Indole-3-lactic acid AHR Epidermal differentiation

SIRPαengagement regulates ILC2 effector function and alleviates airway hyperreactivity via modulating energy metabolism: 《Cellular & Molecular Immunology》2024年第10期1158-1174,共17页Yoshihiro Sakano Kei Sakano Benjamin PHurrell Pedram Shafiei-Jahani Mohammad Hossein Kazemi Xin Li Stephen Shen Richard Barbers Omid Akbari; supported by R01 HL144790,R01 HL151493,R01 AI145813,R01 AI169687,R01 HL151769,R01 HL 159804 grant from the National Institutes of Health,Public Health Service(O.A.).Schematic diagrams(Figure 4E and Figure 6K)were designed with Biorender.com.; Group-2 innate lymphoid cells(ILC2)are part of a growing family of innate lymphocytes known for their crucial role in both the development and exacerbation of allergic asthma.The activation and function of ILC2s are r...; 关键词：SIRPa CD47 ILC2 AHR ASTHMA

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

AHR

检索结果分析

下载全文

高级检索检索式检索

时间限定

期刊范围

学科限定全选

高级检索 检索式检索

时间限定

期刊范围

学科限定全选

AHR

检索结果分析

下载全文

用户登录

高级检索检索式检索