Skin Rejuvenation in Aged Mice by Fecal Microbiota Transplantation from Young Mice Feces  

作　　者：Shoujuan Yu Ziyang Li Xiaoxu Zhang Qi Zhang Liwei Zhang Liang Zhao Ping Liu Jie Guo Juan Chen Chengying Zhang Xinjuan Liu Mengyang Yu Dekui Jin Xiaofeng Wang Guang Li Yan Cao Fazheng Ren Ran Wang 

机构地区：[1]Key Laboratory of Functional Dairy,Co-Constructed by Ministry of Education and Beijing Government,Department of Nutrition and Health,China Agricultural University,Beijing 100193,China [2]Advanced Innovation Center for Food Nutrition and Human Health,Department of Nutrition and Health,China Agricultural University,Beijing 100193,China [3]Research Center for Probiotics,China Agricultural University,Beijing 100083,China [4]Department of General Practice,The Third Centers of Chinese PLA General Hospital,Beijing 100039,China [5]Department of Gastroenterology,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China [6]Department of Gastroenterology,The Third Centers of Chinese PLA General Hospital,Beijing 100039,China

出　　处：《Engineering》2024年第11期26-38,共13页工程（英文）

基　　金：supported in part by grants from the National Key Research and Development Program of China(2021YFD1600204 and 2023YFF1104500);the 111 project from the Ministry of Education of the People’s Republic of China 577(B18053).

摘　　要：Skin aging is an increasingly prominent topic in the context of healthy aging.During the aging process,the skin’s barrier function diminishes,its water content decreases,wrinkles begin to form,and changes occur in the gut microbiota composition.However,the relationship between gut microbiota and skin aging remains unclear.In this study,we explored skin rejuvenation in aged mice through fecal microbiota trans-plantation(FMT)using feces from young mice.The results demonstrated enhanced water retention,thick-ened stratum corneum,increased collagen content,and improved epithelial cell differentiation in aged mice following FMT.Notably,FMT particularly increased the abundance of Lactobacillus and Lactococcus in aged mice,which were nearly undetectable in untreated aged mice.Non-targeted and targeted meta-bolomics analyses indicated that FMT significantly elevated levels of tryptophan(Trp)and its microbiota metabolites(e.g.,indole-3-lactic acid(ILA))in the feces and serum of aged mice.Both Trp and ILA appeared to rejuvenate aged skin by activating the aryl hydrocarbon receptor(AhR)to promote epidermal cell dif-ferentiation.In conclusion,FMT from young mice rejuvenated aged skin via Trp-metabolizing bacteria(Lactobacillus and Lactococcus)and Trp-derived metabolites,suggesting that interventions targeting Trp metabolites may effectively improve skin aging.

关 键 词：Skin aging FMT TRYPTOPHAN Indole-3-lactic acid AHR Epidermal differentiation 

分 类 号：R622[医药卫生—整形外科]