TRYPTOPHAN

作品数：138被引量：339H指数：10
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Fructose aggravating colon barrier dysfunction by decreasing gut bacteria metabolites indole-3-carboxaldehyde and inhibiting activation of aryl hydrocarbon receptor in vivo and in vitro
《Food Science and Human Wellness》2025年第4期1480-1497,共18页Ge Song Shaojie Pang Wenting Peng Wei Fang Yong Wang Rui Liu Qianyun Gan Wentao Qi 
supported by the Special Funds of Basic Research of Central Public Welfare Institute(JY2010 and ZX2410)。
Background:Fructose may induce non-alcoholic fatty acids(NAFLD)due to the gut-liver axis interactions.The mechanism of fructose impairing colon barrier is unrevealed.Methods:Normal and dextran sulfate sodium(DSS)-indu...
关键词：FRUCTOSE Tryptophan metabolites Colon barrier 
Dip2a regulates stress susceptibility in the basolateral amygdala
《Neural Regeneration Research》2025年第6期1735-1748,共14页Jing Li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu 
supported by the STI 2030—Major Projects 2021ZD0204000,No.2021ZD0204003 (to XZ);the National Natural Science Foundation of China,Nos.32170973 (to XZ),32071018 (to ZH)。
Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types...
关键词：5-HYDROXYTRYPTAMINE acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics NEUROTRANSMITTERS principal component analysis stress susceptibility TRYPTOPHAN 
Lactiplantibacillus plantarum DPUL-S164 regulate aryl hydrocarbon receptors signaling to ameliorate dextran sodium sulfate-induced intestinal barrier damage by producing indole-3-lactic acid in a tryptophan-rich diet
《Food Science and Human Wellness》2025年第3期981-997,共17页Arong Wang Dashuai He Tieqi Wang Cheng Guan Guangqing Mu Yanfeng Tuo 
project was supported by the National Key Research and Development Program(2021YFD2100700)。
The aim of this paper was to study the effect of combination of Lactobacillus strains and tryptophan(Trp)-rich diet on the intestinal barrier function of Balb/c mice exposed to a cocktail of antibiotics and dextran so...
关键词：Intestinal barrier injury LACTOBACILLUS Aryl hydrocarbon receptor Indole-3-lactic acid 
Targeting gut microbiota and its associated metabolites as a potential strategy for promoting would healing in diabetes
《World Journal of Diabetes》2025年第5期16-30,共15页Ling Xiong Ya-Xin Huang Lan Mao Yong Xu Yong-Qiong Deng 
Supported by Sichuan Provincial Department of Science and Technology Youth Fund Project,No.2024NSFSC1609;Sichuan Province Postdoctoral Special Funding Project,No.TB2023046。
Impaired healing of diabetic wounds is one of the most important complications of diabetes,often leading to lower limb amputations and incurring significant economic and psychosocial costs.Unfortunately,there are curr...
关键词：Type 2 diabetes Wound healing Gut microbiota Short chain fatty acids TRYPTOPHAN Bile acids Hydrogen sulfide 
Understanding the mechanism underlying the anti-inflammatory effect of dietary flavonoids on IBD:a focus on gut microbiota and its metabolites involved in SCFA,bile acid,tryptophan and lipopolysaccharides
《Food Science and Human Wellness》2025年第2期385-403,共19页Huihui Xiong Hui Chen Lingli Chen Kehui Ouyang Suyun Lin Wenjun Wang 
supported by grants from the National Natural Science Foundation of China(31560459);Jiangxi Provincial Natural Science Foundation(20224ACB205014);The Double Thousands Talents Plan of Jiangxi(jxsq2018102075,jxsq2018102076)。
Inflammatory bowel disease(IBD)is a chronic gastrointestinal disease with a high incidence.Treatment for IBD includes medications and diet,and common anti-inflammatory medications have limitations like drug resistance...
关键词：Dietary flavonoids Inflammatory bowel disease Gut microbiota METABOLITES Mechanisms 
Biopolymer Decorated Pencil Graphite Electrode for the In-situ Quantification of L-Tryptophan in Dietary Supplements
《Journal of Analysis and Testing》2025年第1期82-95,共14页V.Devika P.J.Sreelekshmi B.Vedhanarayanan Sandhya Sadanandan R.Rejithamol 
A simplistic and novel electrochemical sensor for selectively detecting the essential amino acid tryptophan in dietary supplements was fabricated on a pencil graphite electrode modified with a tryptophan-based dipepti...
关键词：TRYPTOPHAN DIPEPTIDE ELECTROPOLYMERIZATION Electrochemical sensor VOLTAMMETRY 
Exploring Protein Bioconjugation:A Redox-Based Strategy for Tryptophan Targeting
《Research》2025年第1期578-580,共3页Qian-Qian Yang Shuai-Jiang Liu Wei Huang Cheng Peng Bo Han 
financial support from the National Natural Science Foundation of China(82374020 and 82374155);Science and Technology Department of Sichuan Province(2023ZYD0054 and 2024NSFTD0023);the Innovation Team and Talents Cultivation Program of National Administration of Traditional Chinese Medicine(ZYYCXTD-D-202209).
Amino acid bioconjugation technology has emerged as a pivotal tool for linking small-molecule fragments with proteins,antibodies,and even cells.The study in Nature by Chang and Toste introduces a redox-based strategy ...
关键词：click reactionsmeanwhilethis small molecule fragments protein bioconjugation redox based strategy tryptophan targeting amino acid bioconjugation oxidative cyclization reagentsdemonstrating 
Gut microbiota-derived tryptophan metabolites regulated by Wuji Wan to attenuate colitis through AhR signaling activation
《Acta Pharmaceutica Sinica B》2025年第1期205-223,共19页Wanghui Jing Sijing Dong Yinyue Xu Jingjing Liu Jiawei Ren Xue Liu Min Zhu Menggai Zhang Hehe Shi Na Li Peng Xia Haitao Lu Sicen Wang 
supported by the National Natural Scientific Foundation of China(82174059);Outstanding young and middleaged science and technology talents of Shaanxi Administration of Traditional Chinese Medicine(2023-ZQNY-004,China);the Natural Science Foundation of Shaanxi Province(2022SF-123,China);Innovative talent team introduction project in Xinzhou City(20220701,China);the Project of Shaanxi Administration of Traditional Chinese Medicine(No.2022-SLRH-YQ-001,China);the SKL-GRF Grant from State Key Laboratory of Environmental and Biological Analysis at Hong Kong Baptist University(SKLP_2425_P02,China).
Disruption of the intestinal mucosal barrier caused by gut dysbiosis and metabolic imbalance is the underlying pathology of inflammatory bowel disease(IBD).Traditional Chinese medicine Wuji Wan(WJW)is commonly used to...
关键词：Wuji Wan COLITIS Gut microbiota Tryptophan metabolite Intestinal barrier Aryl hydrocarbon receptor Indole-3-acetic acid 
Gut microbiota and healthy longevity
《Science China(Life Sciences)》2024年第12期2590-2602,共13页Jia Luo Shan Liang Feng Jin 
supported by the Sichuan Key Research Base Program of Mental Health Education,Southwest Jiaotong University (XLJKJY2015B);Foundation of Sichuan Research Center of Applied Psychology of Chengdu Medical College (CSXL-202A03)。
Recent progress on the underlying biological mechanisms of healthy longevity has propelled the field from elucidating genetic modification of healthy longevity hallmarks to defining mechanisms of gut microbiota influe...
关键词：gut microbiota LONGEVITY healthy aging short-chain fatty acids tryptophan metabolites bile acids 
Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction
《Cancer Communications》2024年第11期1261-1286,共26页Yongcan Liu Shanchun Chen Xueying Wan Rui Wang Haojun Luo Chao Chang Peijin Dai Yubi Gan Yuetong Guo Yixuan Hou Yan Sun Yong Teng Xiaojiang Cui Manran Liu 
supported by National Key Projects of Ministry of Science and Technology of China(MOST 2018YFE0113700);National Natural Science Foundation of China(NSFC82173155,NSFC81874199);the Outstanding Professorship Program of Chongqing Medical University(2019-R10005)to Manran Liu;supported by the Outstanding Postgraduate Fund of Chongqing Medical University(BJRC202021,BJRC202025);the Chongqing Graduate Research and Innovation Project of the Chongqing Education Committee(CYB22218)for Shanchun Chen.
Background:Tumor metastasis is a major threat to cancer patient survival.The organ-specific niche plays a pivotal role in tumor organotropic metas-tasis.Fibroblasts serve as a vital component of the metastatic microen...
关键词：Matrix fibroblasts Lung metastasis Tryptophan 2 3-dioxygenase T cell dysfunction Ferropto-sis 
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