Dip2a regulates stress susceptibility in the basolateral amygdala  

作　　者：Jing Li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu 

机构地区：[1]Key Laboratory of Molecular Epigenetics [2]Ministry of Education,Institute of Genetics and Cytology,Northeast Normal University,Changchun,Jilin Province,China

出　　处：《Neural Regeneration Research》2025年第6期1735-1748,共14页中国神经再生研究（英文版）

基　　金：supported by the STI 2030—Major Projects 2021ZD0204000,No.2021ZD0204003 (to XZ);the National Natural Science Foundation of China,Nos.32170973 (to XZ),32071018 (to ZH)。

摘　　要：Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关 键 词：5-HYDROXYTRYPTAMINE acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics NEUROTRANSMITTERS principal component analysis stress susceptibility TRYPTOPHAN 

分 类 号：R338[医药卫生—人体生理学]