5-HYDROXYTRYPTAMINE

作品数：85被引量：272H指数：9
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相关领域：医药卫生更多>>
相关作者：卢宝华来鲁华李柏岩邢斌赵德化更多>>
相关机构：第四军医大学哈尔滨医科大学北京大学西南大学更多>>
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相关基金：国家自然科学基金中国博士后科学基金国家重点基础研究发展计划河南省自然科学基金更多>>
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Tryptophan metabolism and ischemic stroke:An intricate balance
《Neural Regeneration Research》2026年第2期466-477,共12页Chongjie Yao Dong Xie Yuchen Zhang Yuanhao Shen Pingping Sun Zhao Ma Jin Li Jiming Tao Min Fang 
supported by Shanghai Shenkang Center Demonstration Research Ward Construction,No.SHDC2022CRW010(to MF);Shanghai Shenkang Center Medical Enterprise Integration and Innovation Collaborative Special Project,No.SHDC2022CRT018(to MF);Shanghai Health System Key Supported Discipline-Rehabilitation Medicine,No.2023ZDFC0301(to JT);Science and Technology Development Project of Shanghai University of Traditional Chinese Medicine,No.23KFL009(to JT);Shanghai Postdoctoral Excellence Program,No.2022515(to CY);Yangfan Special Project of Shanghai Science and Technology Innovation Action Plan,No.23YF1447600(to CY);China Postdoctoral Science Foundation,No.2023M732338(to CY).
Ischemic stroke,which is characterized by hypoxia and ischemia,triggers a cascade of injury responses,including neurotoxicity,inflammation,oxidative stress,disruption of the blood-brain barrier,and neuronal death.In t...
关键词：5-HYDROXYTRYPTAMINE cerebral ischemia ischemic stroke KYNURENINE neuroprotection NEUROTOXICITY post-stroke cognitive impairment post-stroke depression SEROTONIN tryptophan metabolism 
Dip2a regulates stress susceptibility in the basolateral amygdala
《Neural Regeneration Research》2025年第6期1735-1748,共14页Jing Li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu 
supported by the STI 2030—Major Projects 2021ZD0204000,No.2021ZD0204003 (to XZ);the National Natural Science Foundation of China,Nos.32170973 (to XZ),32071018 (to ZH)。
Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types...
关键词：5-HYDROXYTRYPTAMINE acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics NEUROTRANSMITTERS principal component analysis stress susceptibility TRYPTOPHAN 
Modified Sijunzi Granules Exhibit Hemostatic Effect by Activating Akt and Erk Signal Pathways via Regulating 5-HT and Its Receptors Levels
《Chinese Journal of Integrative Medicine》2024年第12期1121-1127,共7页WANG Jun ZHANG Xue-ying KANG Yan-hong ZHANG Yun CHEN Xin-yi ZHOU Jia-li MA Wei 
Supported by Natural Science Foundation of Zhejiang Province(No.LQ23H270001)。
Objective:To investigate the hemostatic effect of modified Sijunzi Granules(MSG)in primary immune thrombocytopenia(ITP)zebrafish model and explore the potential mechanism.Methods:AB strain wild type zebrafish were tre...
关键词：modified Sijunzi Granules Chinese medicine primary immune thrombocytopenia zebrafish 5-HYDROXYTRYPTAMINE 5-hydroxytryptamine receptor mitogen-activated protein kinase/extracellular regulated protein kinases signal pathway phosphoinositide3-kinases/protein kinase B signal pathway 
Insights into the anorexic mechanism of Khat:an integrated in vivo,ex vivo,and in silico investigations
《Traditional Medicine Research》2024年第10期36-51,共16页Ahmed Ali Jerah Manal Mohamed Elhassan Taha Abdullah Farasani Sivakumar Sivagurunathan Moni Emad Sayed Shaheen Andleeb Khan Ibrahim Abdo Khardali Magbool Oraiby Heyam Mohamed Ali Sidahmed Siddig Ibrahim Abdelwahab 
The authors extend their appreciation to the Deputyship for Research&Innovation,Ministry of Education in Saudi Arabia,for funding this research work through project number ISP23-82.
Background:Chewing Khat(Catha edulis)releases cathine and cathinone,which may reduce appetite via an unknown mechanism.This study investigated the peripheral and central effects of fresh leaves and buds of Catha eduli...
关键词：Catha edulis APPETITE LEPTIN GHRELIN 5-HYDROXYTRYPTAMINE molecular docking 
Research progress of neurotransmitters related to insomnia
《Journal of Translational Neuroscience》2024年第3期21-25,共5页Changliang Ji Chen Yu Jin Wu Dan Lu 
Insomnia is currently a common phenomenon,which manifests itself as difficulty in falling asleep,problems remaining asleep,or early awakening,and has a serious impact on people’s lives.Neurotransmitters play a key ro...
关键词：INSOMNIA gamma-aminobutyric acid 5-HYDROXYTRYPTAMINE NORADRENALINE ACETYLCHOLINE MELATONIN 
Effects of Dezocine and Propofol Combination on Plasma 5-HT and ET Levels in Stroke Patients Undergoing Thrombolysis
《Journal of Clinical and Nursing Research》2024年第9期234-239,共6页Fangfang Lv Xiuhong Wang Weibo Wang 
Objective: To investigate the effect of dezocine combined with propofol on brain metabolism in patients undergoing cerebral thrombosis thrombolysis. Methods: A total of 86 stroke patients admitted between July 2022 an...
关键词：DEZOCINE PROPOFOL 5-HYDROXYTRYPTAMINE ENDOTHELIN Cerebral apoplexy 
Potential efficacy and mechanism of eight mild-natured and bitterflavored TCMs based on gut microbiota:A review被引量：1
《Chinese Herbal Medicines》2024年第1期42-55,共14页Wenquan Su Yanan Yang Xiaohui Zhao Jiale Cheng Yuan Li Shengxian Wu Chongming Wu 
The authors acknowledge the financial supports of the National Natural Science Foundation of China(No.81973217,82174340).
The mild-natured and bitter-flavored traditional Chinese medicines(MB-TCMs)are an important class of TCMs that have been widely used in clinical practice and recognized as safe long-term treatments for chronic disease...
关键词：bile acid gamma-aminobutyric acid 5-HYDROXYTRYPTAMINE mild-natured and bitter-flavored traditional Chinese medicines property theory short-chain fatty acids traditional Chinese medicine trimethylamine oxide 
Electroacupuncture at Sensitized Acupoints Relieves Somatic Referred Pain in Colitis Rats by Inhibiting Sympathetic-Sensory Coupling to Interferewith 5-HT Signaling Pathway被引量：3
《Chinese Journal of Integrative Medicine》2024年第2期152-162,共11页YANG Ying QU Jin-yu GUO Hua ZHOU Hai-ying RUAN Xia PENG Ying-chun SHEN Xue-fang XIONG Jin WANG Yi-li 
Supported by the National Natural Science Foundation of China(No.82004461);Medical Research Project of Sichuan Province(No.S21099);the First Affiliated Hospital of Chengdu Medical College(No.CYFY2021ZD05,No.CYFY-GQ27);Chengdu Medical College(No.CYZZD20-03,No.202013705082)。
Objective:To investigate whether electroacupuncture(EA) at sensitized acupoints could reduce sympathetic-sensory coupling(SSC) and neurogenic inflammatory response by interfering with 5-hydroxytryptamine(5-HT)ergic ne...
关键词：ELECTROACUPUNCTURE sensitized acupoints sympathetic-sensory coupling 5-HYDROXYTRYPTAMINE neurogenic inflammation somaticreferredpain 
Role of 5-hydroxytryptamine type 3 receptors in the regulation of anxiety reactions被引量：1
《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2024年第1期23-37,共15页Yinan DU Zhiwei LI Yukui ZHAO Jing HAN Weiping HU Zhiqiang LIU 
supported by the National Natural Science Foundation of China(Nos.82071516,32171065,91949105,and 81771227);the Innovation Capability Support Program of Shannxi Province in China(No.2020TD-037);the Fundamental Research Funds for the Central Universities(Nos.GK202105001,GK202205019,and CK202205022),China.
5-Hydroxytryptamine(5-HT)type 3 receptor(5-HT_(3)R)is the only type of ligand-gated ion channel in the 5-HT receptor family.Through the high permeability of Na+,K+,and Ca2+and activation of subsequent voltage-gated ca...
关键词：5-Hydroxytryptamine type 3 receptor(5-HT_(3)R) ANXIETY Medial prefrontal cortex AMYGDALA HIPPOCAMPUS Periaqueductal gray 
Activation of the 5-hydroxytryptamine 4 receptor ameliorates tight junction barrier dysfunction in the colon of type 1 diabetic mice
《Acta Biochimica et Biophysica Sinica》2023年第12期1874-1883,共10页Shasha Hu Yueting Kou Xiaochen Liu Weifang Rong Hongxiu Han Guohua Zhang 
supported by the grants from the National Natural Science Foundation of China (No.81770355 to G.Z.);the Natural Science Foundation of Shanghai (No.23ZR1457700 to H.H.);the Shanghai Tongi Hospital (No.GJPY2123 to H.H.);the Innovative Research Team of High-Level Local Universities in Shanghai (No.SHSMU-ZDCX20211102 to G.Z).
Hyperglycemia drives dysfunction of the intestinal barrier.5-Hydroxytryptaine 4 receptor(5-HT4R)agonists have been considered therapeutics for constipation in clnic.However,the roles of 5-HT4R activation in mucosa sho...
关键词：5-HT4R DIABETES tight junction barrier MLCK ROCK1 
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