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Tryptophan metabolism and ischemic stroke:An intricate balance: 《Neural Regeneration Research》2026年第2期466-477,共12页Chongjie Yao Dong Xie Yuchen Zhang Yuanhao Shen Pingping Sun Zhao Ma Jin Li Jiming Tao Min Fang; supported by Shanghai Shenkang Center Demonstration Research Ward Construction,No.SHDC2022CRW010(to MF);Shanghai Shenkang Center Medical Enterprise Integration and Innovation Collaborative Special Project,No.SHDC2022CRT018(to MF);Shanghai Health System Key Supported Discipline-Rehabilitation Medicine,No.2023ZDFC0301(to JT);Science and Technology Development Project of Shanghai University of Traditional Chinese Medicine,No.23KFL009(to JT);Shanghai Postdoctoral Excellence Program,No.2022515(to CY);Yangfan Special Project of Shanghai Science and Technology Innovation Action Plan,No.23YF1447600(to CY);China Postdoctoral Science Foundation,No.2023M732338(to CY).; Ischemic stroke,which is characterized by hypoxia and ischemia,triggers a cascade of injury responses,including neurotoxicity,inflammation,oxidative stress,disruption of the blood-brain barrier,and neuronal death.In t...; 关键词：5-HYDROXYTRYPTAMINE cerebral ischemia ischemic stroke KYNURENINE neuroprotection NEUROTOXICITY post-stroke cognitive impairment post-stroke depression SEROTONIN tryptophan metabolism

Dual effects of GABA_(A)R agonist anesthetics in neurodevelopmentnd vulnerable brains:From neurotoxic to therapeutic effects: 《Neural Regeneration Research》2026年第1期81-95,共15页Dihan Lu Wen Zhang Keyu Chen Xia Feng; Debates regarding the specific effects of general anesthesia on developing brains have persisted for over 30 years.A consensus has been reached that prolonged,repeated,high-dose exposure to anesthetics is associated w...; 关键词：brain central nervous system cognition gamma-aminobutyric acid type A receptor agonist general anesthetics neurogenesis neurological disorders neuroprotection NEUROTOXICITY signal pathways

NG2 Glia:The Guardians Against Prion‑induced Neurotoxicity Through Prostaglandin E2 Blockade: 《Neuroscience Bulletin》2025年第3期539-542,共4页Shu Feng Emily Parker Timon Cheng‑Yi Liu Luodan Yang; supported by the National Natural Science Foundation of China(32300959);a Guangzhou Scientific Research Grant(SL2024A04J00578);the SCNU Young Faculty Development Program(22KJ04).; Neuron glia antigen-2(NG2)glia,also known as oligodendrocyte precursor cells(OPCs),are essential for maintaining the normal function and structure of the central nervous system(CNS)due to their supportive role[1].Unde...; 关键词：maintaining normal function structure myelin sheath axons oligodendrocyte precursor cells opcs receiving synaptic input neurons NEUROTOXICITY PRION central nervous system cns due ng glia

Hydrogen Sulfide Prevents ATP-induced Neurotoxicity via Inhibiting The NLRP1/caspase-1/gasdermin D-mediated Pyroptosis Pathway: 《生物化学与生物物理进展》2025年第3期724-734,共11页REN Yan-Kai LI Ying-Hong LI Man-Li YANG Kun-Li FAN Zhi-Ru ZHANG Si-Yu LI Dong-Liang; 河南省重点研发与推广专项(科技攻关)(202102310081);河南省高等学校重点科研项目(20B310014);新乡医学院三全学院培育项目(XJKT201909);河南省重点学科(教研[2023]414号);河南省卫计委联合攻关项目(2018020386)资助。; Objective Stroke is a leading cause of death and disability worldwide,with ischemic stroke accounting for 80%-85%of cases.Despite the prevalence,effective treatments remain scarce.The compelling evidence suggest that ...; 关键词：STROKE ATP H2S NLRP1 CASPASE-1 GSDMD PYROPTOSIS

Establishment of human cerebral organoid systems to model early neural development and assess the central neurotoxicity of environmental toxins: 《Neural Regeneration Research》2025年第1期242-252,共11页Daiyu Hu Yuanqing Cao Chenglin Cai Guangming Wang Min Zhou Luying Peng Yantao Fan Qiong Lai Zhengliang Gao; supported by the National Key R&D Program of China,No.2019YFA0110300(to ZG);the National Natural Science Foundation of China,Nos.81773302(to YF),32070862(to ZG).; Human brain development is a complex process,and animal models often have significant limitations.To address this,researchers have developed pluripotent stem cell-derived three-dimensional structures,known as brain-li...; 关键词：cadmium cell death cell proliferation cortical development environmental toxins neural progenitor cells NEUROGENESIS NEUROTOXICOLOGY ORGANOIDS stem cells

The Role of Intravenous Anesthetics for Neuro:Protection or Toxicity?: 《Neuroscience Bulletin》2025年第1期107-130,共24页Kaixin Wang Yafeng Wang Tianhao Zhang Bingcheng Chang Daan Fu Xiangdong Chen; supported by the National Key Research and Development Program of China(2018YFC2001802);the National Natural Science Foundation of China(82303765 and 82071251);Hubei Province Key Research and Development Program(2021BCA145);Open Foundation of Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research(2022zsyx008);Program of Scientifc and Technological Project in Guizhou Province(Qian Ke He Ji Chu ZK[2022]Yi Ban 516 and Qian Ke He Ji Chu ZK[2021]Yi Ban 559);the Science and Technology Talents Growth Project in Education Department of Guizhou Province(Qian Jiao He KY Zi[2021]4Y211);Research project of Guizhou Administration of Traditional Chinese Medicine(QZYY-2021-082).; The primary intravenous anesthetics employed in clinical practice encompass dexmedetomidine(Dex),propofol,ketamine,etomidate,midazolam,and remimazolam.Apart from their established sedative,analgesic,and anxiolytic pro...; 关键词：Intravenous anesthetics Neuronal injury NEUROPROTECTION NEUROTOXICITY CNS PNS

Adverse outcome pathway for the neurotoxicity of per-and polyfluoroalkyl substances:A systematic review: 《Eco-Environment & Health》2024年第4期476-493,共18页Shenpan Li Shuangjian Qin Huixian Zeng Weichun Chou Anna Oudin Katja M.Kanninen Pasi Jalava Guanghui Dong Xiaowen Zeng; supported by the National Natural Science Foundation of China (No.82073503);the Natural Science Foundation of Guangdong Province (No.2021B1515020015);the Guangzhou Science and Technology Project (No.2024A04J6476).; Per-and polyfluoroalkyl substances(PFAS)are endocrine disruptors with unambiguous neurotoxic effects.However,due to variability in experimental models,population characteristics,and molecular endpoints,the elucidation...; 关键词：PFAS Adverse outcome pathway NEUROTOXICITY Thyroid hormones Risk assessment

Effects on Synaptic Plasticity Markers in Fetal Mice and HT22 Neurons upon F‑53B Exposure:The Role of PKA Cytoplasmic Retention: 《Environment & Health》2024年第11期776-785,共10页Shen-Pan Li Hui-Xian Zeng Shuang-Jian Qin Qing-Qing Li Lu-Yin Wu Qi-Zhen Wu Li-Zi Lin Guang-Hui Dong Xiao-Wen Zeng; supported by the National Science Foundation of China(No.82073503,82173471,82003409,82103823);the Natural Science Foundation of Guangdong Province(No.2021B1515020015,2021A1515012212);the Guangzhou Science and Technology Plan Project(No.2024A04J6476).; Chlorinated polyfluorinated ether sulfonate(F-53B),a chromium-fog depressant widely utilized as an alternative to perfluorooctanesulfonate,can transfer from mother to fetus.Recent research has demonstrated that prenat...; 关键词：F-53B Synaptic plasticity PKA/CREB signaling pathway Early neurotoxicity PKA cytoplasmic retention

Ruxolitinib improves the inflammatory microenvironment,restores glutamate homeostasis,and promotes functional recovery after spinal cord injury被引量：1: 《Neural Regeneration Research》2024年第11期2499-2512,共14页Jiang Cao Xiao Yu Jingcheng Liu Jiaju Fu Binyu Wang Chaoqin Wu Sheng Zhang Hongtao Chen Zi Wang Yinyang Xu Tao Sui Jie Chang Xiaojian Cao; supported by the National Natural Science Foundation of China,No.82272484(to XC).; The inflammatory microenvironment and neurotoxicity can hinder neuronal regeneration and functional recovery after spinal cord injury.Ruxolitinib,a JAK-STAT inhibitor,exhibits effectiveness in autoimmune diseases,arth...; 关键词：astrocytes EAAT2 EXCITOTOXICITY glutamate homeostasis JAK-STAT pathway locomotor function NEUROTOXICITY RUXOLITINIB spinal cord injury transcriptome analysis

Conformational dynamics as an intrinsic determinant of prion protein misfolding and neurotoxicity: 《Neural Regeneration Research》2024年第10期2095-2096,共2页Alessandro Cembran Pedro Fernandez-Funez; supported by the NIH grant7R21 NS09662 7-02 to PFF;the Winston and Maxine Wallin Neuroscience Discovery Fund award CON000000083928 to PFF and AC。; The prion protein(PrP) is the key molecular and pathological mediator of prion diseases,a heterogeneous group of brain disorders with fatal outcomes.Prion diseases are rare but deserve special attention because of the...; 关键词：FOLDING INTRINSIC DYNAMICS

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