The Role of Intravenous Anesthetics for Neuro:Protection or Toxicity?  

作　　者：Kaixin Wang Yafeng Wang Tianhao Zhang Bingcheng Chang Daan Fu Xiangdong Chen 

机构地区：[1]Department of Anesthesiology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China [2]Institute of Anesthesia and Critical Care Medicine,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China [3]Key Laboratory of Anesthesiology and Resuscitation,(Huazhong University of Science and Technology),Ministry of Education,Wuhan 430022,China [4]The Second Afliated Hospital of Guizhou,University of Traditional Chinese Medicine,Guiyang 550003,China

出　　处：《Neuroscience Bulletin》2025年第1期107-130,共24页神经科学通报(英文版)

基　　金：supported by the National Key Research and Development Program of China(2018YFC2001802);the National Natural Science Foundation of China(82303765 and 82071251);Hubei Province Key Research and Development Program(2021BCA145);Open Foundation of Hubei Key Laboratory of Regenerative Medicine and Multi-disciplinary Translational Research(2022zsyx008);Program of Scientifc and Technological Project in Guizhou Province(Qian Ke He Ji Chu ZK[2022]Yi Ban 516 and Qian Ke He Ji Chu ZK[2021]Yi Ban 559);the Science and Technology Talents Growth Project in Education Department of Guizhou Province(Qian Jiao He KY Zi[2021]4Y211);Research project of Guizhou Administration of Traditional Chinese Medicine(QZYY-2021-082).

摘　　要：The primary intravenous anesthetics employed in clinical practice encompass dexmedetomidine(Dex),propofol,ketamine,etomidate,midazolam,and remimazolam.Apart from their established sedative,analgesic,and anxiolytic properties,an increasing body of research has uncovered neuroprotective efects of intravenous anesthetics in various animal and cellular models,as well as in clinical studies.However,there also exists conficting evidence pointing to the potential neurotoxic efects of these intravenous anesthetics.The role of intravenous anesthetics for neuro on both sides of protection or toxicity has been rarely summarized.Considering the mentioned above,this work aims to ofer a comprehensive understanding of the underlying mechanisms involved both in the central nerve system(CNS)and the peripheral nerve system(PNS)and provide valuable insights into the potential safety and risk associated with the clinical use of intravenous anesthetics.

关 键 词：Intravenous anesthetics Neuronal injury NEUROPROTECTION NEUROTOXICITY CNS PNS 

分 类 号：R61[医药卫生—外科学]