KYNURENINE

作品数：31被引量：91H指数：5
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相关领域：医药卫生更多>>
相关作者：夏晓萍唐爱国徐雪梅周楠楠肖乐东更多>>
相关机构：浙江大学医学院附属妇产科医院中南大学湘雅二医院陕西中医药大学附属医院陕西中医药大学更多>>
相关期刊：《American Journal of Plant Sciences》《Neural Regeneration Research》《Food and Nutrition Sciences》《成都医学院学报》更多>>
相关基金：国家自然科学基金广东省自然科学基金国家教育部博士点基金更多>>
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Tryptophan metabolism and ischemic stroke:An intricate balance
《Neural Regeneration Research》2026年第2期466-477,共12页Chongjie Yao Dong Xie Yuchen Zhang Yuanhao Shen Pingping Sun Zhao Ma Jin Li Jiming Tao Min Fang 
supported by Shanghai Shenkang Center Demonstration Research Ward Construction,No.SHDC2022CRW010(to MF);Shanghai Shenkang Center Medical Enterprise Integration and Innovation Collaborative Special Project,No.SHDC2022CRT018(to MF);Shanghai Health System Key Supported Discipline-Rehabilitation Medicine,No.2023ZDFC0301(to JT);Science and Technology Development Project of Shanghai University of Traditional Chinese Medicine,No.23KFL009(to JT);Shanghai Postdoctoral Excellence Program,No.2022515(to CY);Yangfan Special Project of Shanghai Science and Technology Innovation Action Plan,No.23YF1447600(to CY);China Postdoctoral Science Foundation,No.2023M732338(to CY).
Ischemic stroke,which is characterized by hypoxia and ischemia,triggers a cascade of injury responses,including neurotoxicity,inflammation,oxidative stress,disruption of the blood-brain barrier,and neuronal death.In t...
关键词：5-HYDROXYTRYPTAMINE cerebral ischemia ischemic stroke KYNURENINE neuroprotection NEUROTOXICITY post-stroke cognitive impairment post-stroke depression SEROTONIN tryptophan metabolism 
Kynurenine-AhR reduces T-cell infiltration and induces a delayed T-cell immune response by suppressing the STAT1-CXCL9/CXCL10 axis in tuberculosis
《Cellular & Molecular Immunology》2024年第12期1426-1440,共15页Xin Liu Mengjie Yang Ping Xu Mingwei Du Shanshan Li Jin Shi Qiang Li Jinfeng Yuan Yu Pang 
supported by the National Key Research and Development Program of China(2022YFC2302901);the National Natural Science Foundation of China(82272346,82072243,82202530);the Sponsored by Beijing Nova Program(20220484169,20230484295);the Provincial Key Research and Development Program of Jiangsu in Social Development(BE2023718).
Tuberculosis,caused by Mycobacterium tuberculosis(Mtb),is a critical global health issue that is complicated by the ability of the pathogen to delay the host’s T-cell immune response.This delay in T-cell recruitment ...
关键词：Mycobacterium tuberculosis Tryptophan metabolism IDO1 IMMUNOSUPPRESSION CHEMOKINES 
Tryptophan 2,3-dioxygenase-positive matrix fibroblasts fuel breast cancer lung metastasis via kynurenine-mediated ferroptosis resistance of metastatic cells and T cell dysfunction
《Cancer Communications》2024年第11期1261-1286,共26页Yongcan Liu Shanchun Chen Xueying Wan Rui Wang Haojun Luo Chao Chang Peijin Dai Yubi Gan Yuetong Guo Yixuan Hou Yan Sun Yong Teng Xiaojiang Cui Manran Liu 
supported by National Key Projects of Ministry of Science and Technology of China(MOST 2018YFE0113700);National Natural Science Foundation of China(NSFC82173155,NSFC81874199);the Outstanding Professorship Program of Chongqing Medical University(2019-R10005)to Manran Liu;supported by the Outstanding Postgraduate Fund of Chongqing Medical University(BJRC202021,BJRC202025);the Chongqing Graduate Research and Innovation Project of the Chongqing Education Committee(CYB22218)for Shanchun Chen.
Background:Tumor metastasis is a major threat to cancer patient survival.The organ-specific niche plays a pivotal role in tumor organotropic metas-tasis.Fibroblasts serve as a vital component of the metastatic microen...
关键词：Matrix fibroblasts Lung metastasis Tryptophan 2 3-dioxygenase T cell dysfunction Ferropto-sis 
Metabolic landscape of head and neck squamous cell carcinoma informs a novel kynurenine/Siglec-15 axis in immune escape被引量：1
《Cancer Communications》2024年第6期670-694,共25页Xin-Yu Zhang Jian-Bo Shi Shu-Fang Jin Rui-Jie Wang Ming-Yu Li Zhi-Yuan Zhang Xi Yang Hai-Long Ma 
National Natural Science Foundation of China,Grant/Award Numbers:82303280,82072980,82272831,82272983,82172897,82203614;Science and Technology Daystar Program of Shanghai,Grant/Award Number:22QA1405300;Natural Science Foundation of Shanghai,Grant/Award Numbers:22ZR1436800,20ZR1447300;Young Talent Lift Project by the China Association for Science and Technology,Grant/Award Number:2020QNRC001;Shanghai Sailing Program,Grant/Award Number:22YF1421600;Young physicians collaborative innovation team of Shanghai Ninth People’s Hospital,Grant/Award Number:QC202004;The Innovative Research Team of High-level Local Universities in Shanghai,Grant/Award Numbers:SHSMU-ZDCX20212500,SHSMU-ZLCX20212300。
Background:Metabolic reprograming and immune escape are two hallmarksof cancer.However,how metabolic disorders drive immune escape in head andneck squamous cell carcinoma(HNSCC)remains unclear.Therefore,the aim ofthe ...
关键词：head and neck squamous cell carcinoma KYNURENINE Siglec-15 T cell exhaustion untargeted metabolomics 
Tryptophan Metabolism and Gut Microbiota
《Food and Nutrition Sciences》2023年第8期777-790,共14页Akikazu Takada 
Background: Tryptophan metabolites such as serotonin, kynurenine, or kynurenic acids are considered to be the most important metabolites of gut microbiota. We wanted to know about changes in tryptophan metabolites in ...
关键词：TRYPTOPHAN SEROTONIN MICROBIOTA DEPRESSION Obesity KYNURENINE Blood Brain Barrier KYNURENINE Permeability AUTISM DEPRESSION Diabetes 
Kynurenine pathway of tryptophan metabolism in pathophysiology and therapy of major depressive disorder被引量：1
《World Journal of Psychiatry》2023年第4期141-148,共8页Abdulla A-B Badawy Shazia Dawood Samina Bano 
Serotonin deficiency in major depressive disorder(MDD)has formed the basis of antidepressant drug development and was originally attributed to induction of the major tryptophan(Trp)-degrading enzyme,liver Trp 2,3-diox...
关键词：Major depressive disorder Indoleamine 2 3-dioxygenase Kynurenine monooxygenase Proinflammatory cytokines Serotonin deficiency Tryptophan 2 3-dioxygenase 
Characterizing the influence of gut microbiota on host tryptophan metabolism with germ-free pigs被引量：1
《Animal Nutrition》2022年第4期190-200,共11页Bingnan Liu Dongming Yu Jing Sun Xiaoyan Wu Zhongquan Xin Baichuan Deng Lijuan Fan Jian Fu Liangpeng Ge Wenkai Ren 
National Key R&D Program of China(2021YFD1300700);Laboratory of Lingnan Modern Agriculture Project(NT2021005)。
Intestinal microbes are closely associated with host health,depending on metabolic crosstalk between the microbiota and host.Tryptophan metabolism is one of the best examples of metabolic crosstalk between intestinal ...
关键词：Germ-free pig Gut microbiota TRYPTOPHAN INDOLE KYNURENINE 
Gut Microbiota-Controlled Tryptophan Metabolism Improves D-Gal/LPS-Induced Acute Liver Failure in C57BL/6 Mice被引量：1
《Engineering》2022年第7期134-146,共13页Zhipeng Zheng Li Wu Yuqiu Han Jun Chen Shuai Zhu Yuanyuan Yao Baohong Wang Lanjuan Li 
the Major Program of the National Natural Science Foundation of China(81790630 and 81790633);the Sino-German Center for Research Promotion(GZ1546);the Chinese Academy of Medical Sciences(CAMS)Innovation Fund for Medical Sciences(2019-I2M-5-045).
Acute liver failure(ALF)has an abrupt onset with a frequently fatal outcome.Previous studies have found that oral antibiotics prevent drug-induced liver injury in animal experiments,indicating that the gut microbiota ...
关键词：Gut microbiota Antibiotic TRYPTOPHAN KYNURENINE Aryl hydrocarbon receptor Acute liver failure 
Highly sensitive luminescent lanthanide metal-organic framework sensor for L-kynurenine被引量：4
《Journal of Rare Earths》2022年第3期415-420,I0002,共7页Ting Tang Min Liu Zhao Chen Xingxiang Wang Chunguang Lai Liwen Ding Chenghui Zeng 
Project supported by the National Natural Science Foundation of China(51962008);Jiangxi Provincial Natural Science Foundation(20202BABL203018)。
L-kynurenine(L-kyn)is a marker of prostate cancer.At present,the expensive instruments are usually applied to detect L-kyn clinically,which limits its wide application for cancer diagnosis.Herein,three lanthanide meta...
关键词：Sensitive Lanthanide metal-organic frameworks(LnMOFs) Sensor Prostate cancer marker L-kynurenine(L-kyn) Rare earths 
Novel molecular panel for evaluating systemic inflammation and survival in therapy naïve glioma patients被引量：3
《World Journal of Clinical Oncology》2021年第10期947-959,共13页Puneet Gandhi Richa Shrivastava Nitin Garg Sandeep K Sorte 
Major Project Sanctioned by the Madhya Pradesh Council of Science&Technology to Dr.Puneet Gandhi,No.249.
BACKGROUND Inflammation is crucial to tumor progression.A traumatic event at a specific site in the brain activates the signaling molecules,which triggers inflammation as the initial response within the tumor and its ...
关键词：CIRCULATING GLIOMA Inflammatory marker KYNURENINE NON-INVASIVE PROGNOSTIC 
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